118249-08-4 Usage
General Description
1-(2-(3-iodo-4-azidophenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)piperazine is a chemical compound used in scientific research and drug development. It belongs to the class of piperazine derivatives, which have diverse pharmacological activities. This specific compound contains a piperazine ring connected to a phenyl ring substituted with an iodine and an azide group, as well as another phenyl ring substituted with a trifluoromethyl group. The presence of these functional groups makes it a potentially important compound for medicinal chemistry and pharmaceutical applications. It may have potential use as a molecular probe in biological studies or as a lead compound for drug discovery. Further research is needed to understand its full potential and application in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 118249-08-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,2,4 and 9 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 118249-08:
(8*1)+(7*1)+(6*8)+(5*2)+(4*4)+(3*9)+(2*0)+(1*8)=124
124 % 10 = 4
So 118249-08-4 is a valid CAS Registry Number.
InChI:InChI=1/C19H19F3IN5/c20-19(21,22)15-2-1-3-16(13-15)28-10-8-27(9-11-28)7-6-14-4-5-18(25-26-24)17(23)12-14/h1-5,12-13H,6-11H2
118249-08-4Relevant articles and documents
Preparation and biodistribution of -[125I]Iodo-4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine and -[125I]Iodo-4-azidophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine
Chumpradit,Kung,Billings,Guo,Wu,Shih
, p. 543 - 547 (2007/10/02)
The iodinated analogue of 1-[2-(4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (PAPP), IPAPP (4), and the corresponding azido compound azido-IPAPP (5) were synthesized. The corresponding no-carrier-added 125I (T( 1/2 ) = 60 days, 35-60 keV) labeled compounds were also prepared. High specific binding was observed from in vitro binding studies using rat brain tissue preparation; K(i) = 20 and 17.5 nM against [3H]-5-HT. In vivo biodistribution studies in rats showed that azido-[125I]IPAPP passed through intact blood-brain barrier and localized in the brain. Ex vivo autoradiography of rat brain sections exhibited a diffuse uptake pattern, which may be due to specific and nonspecific binding. The results indicate that IPAPP and azido-IPAPP may not be suitable to image the serotonin receptor in the brain.
