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1-<2-(4-Nitrophenyl)ethyl>-4-<3-(trifluoromethyl)phenyl>piperazine is a complex organic compound with the molecular formula C22H22F3N5O2. It features a piperazine core, which is a heterocyclic amine consisting of a six-membered ring with two nitrogen atoms. The compound has two phenyl rings attached to the piperazine, one at the 1-position and the other at the 4-position. The phenyl ring at the 1-position is substituted with a 4-nitro group, while the phenyl ring at the 4-position has a 3-trifluoromethyl group. This chemical structure contributes to its potential applications in pharmaceuticals and chemical research, as it may exhibit specific biological activities or reactivity due to its unique arrangement of functional groups.

2195-13-3

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2195-13-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2195-13-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,9 and 5 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2195-13:
(6*2)+(5*1)+(4*9)+(3*5)+(2*1)+(1*3)=73
73 % 10 = 3
So 2195-13-3 is a valid CAS Registry Number.

2195-13-3Relevant academic research and scientific papers

Preparation and biodistribution of -[125I]Iodo-4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine and -[125I]Iodo-4-azidophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine

Chumpradit,Kung,Billings,Guo,Wu,Shih

, p. 543 - 547 (2007/10/02)

The iodinated analogue of 1-[2-(4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (PAPP), IPAPP (4), and the corresponding azido compound azido-IPAPP (5) were synthesized. The corresponding no-carrier-added 125I (T( 1/2 ) = 60 days, 35-60 keV) labeled compounds were also prepared. High specific binding was observed from in vitro binding studies using rat brain tissue preparation; K(i) = 20 and 17.5 nM against [3H]-5-HT. In vivo biodistribution studies in rats showed that azido-[125I]IPAPP passed through intact blood-brain barrier and localized in the brain. Ex vivo autoradiography of rat brain sections exhibited a diffuse uptake pattern, which may be due to specific and nonspecific binding. The results indicate that IPAPP and azido-IPAPP may not be suitable to image the serotonin receptor in the brain.

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