2195-13-3

Basic information

• Product Name: 1-<2-(4-Nitrophenyl)ethyl>-4-<3-(trifluoromethyl)phenyl>piperazine
• Synonyms: 1-<2-(4-Nitrophenyl)ethyl>-4-<3-(trifluoromethyl)phenyl>piperazine
• CAS NO: 2195-13-3
• Molecular Weight: 379.382
• Mol File: 2195-13-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-<2-(4-Nitrophenyl)ethyl>-4-<3-(trifluoromethyl)phenyl>piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-<2-(4-Nitrophenyl)ethyl>-4-<3-(trifluoromethyl)phenyl>piperazine(2195-13-3)
• EPA Substance Registry System: 1-<2-(4-Nitrophenyl)ethyl>-4-<3-(trifluoromethyl)phenyl>piperazine(2195-13-3)

Safety Data

• Hazardous Substances Data: 2195-13-3(Hazardous Substances Data)

Upstream product

• 68123-33-1 4-nitrophenylacetic acid O-(N-hydroxy)succinimide ester 
• 104-03-0 4-nitrobenzeneacetic acid 
• 2823-65-6 1-<2-(4-Nitrophenyl)acetyl>-4-<3-(trifluoromethyl)phenyl>piperazine 

Downstream Products

• 118249-08-4 1-[2-(3-Iodo-4-azidophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine 
• 118249-07-3 1-[2-(3-Iodo-4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine 
• 1814-64-8 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine 

Relevant articles and documents

Preparation and biodistribution of -[125I]Iodo-4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine and -[125I]Iodo-4-azidophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine

The iodinated analogue of 1-[2-(4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (PAPP), IPAPP (4), and the corresponding azido compound azido-IPAPP (5) were synthesized. The corresponding no-carrier-added 125I (T( 1/2 ) = 60 days, 35-60 keV) labeled compounds were also prepared. High specific binding was observed from in vitro binding studies using rat brain tissue preparation; K(i) = 20 and 17.5 nM against [3H]-5-HT. In vivo biodistribution studies in rats showed that azido-[125I]IPAPP passed through intact blood-brain barrier and localized in the brain. Ex vivo autoradiography of rat brain sections exhibited a diffuse uptake pattern, which may be due to specific and nonspecific binding. The results indicate that IPAPP and azido-IPAPP may not be suitable to image the serotonin receptor in the brain.