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119341-64-9

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119341-64-9 Usage

Description

(S)-(-)-1-(6-Methoxy-2-naphthyl)ethanol is a chiral organic compound with the molecular formula C13H14O2. It features a naphthalene ring with a methoxy group and an ethyl alcohol group attached, which contributes to its unique chemical properties and potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
(S)-(-)-1-(6-Methoxy-2-naphthyl)ethanol is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its chiral nature makes it a valuable component in the development of new drugs and medications.
Used in Chromatography:
(S)-(-)-1-(6-Methoxy-2-naphthyl)ethanol is used as a chiral resolving agent in chromatography. Its ability to separate enantiomers is crucial for the analysis and purification of chiral compounds, which is essential in the pharmaceutical and chemical industries.
Used in Antioxidant and Anti-Inflammatory Applications:
Due to its potential anti-inflammatory and antioxidant properties, (S)-(-)-1-(6-Methoxy-2-naphthyl)ethanol is being studied for its use in the development of treatments for various inflammatory and oxidative stress-related conditions.
Used in Cancer Research and Treatment:
(S)-(-)-1-(6-Methoxy-2-naphthyl)ethanol is being investigated for its potential use in the treatment of cancer and other diseases. Its ability to inhibit certain enzymes and pathways within the body makes it a promising candidate for further research and development in this area.

Check Digit Verification of cas no

The CAS Registry Mumber 119341-64-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,3,4 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 119341-64:
(8*1)+(7*1)+(6*9)+(5*3)+(4*4)+(3*1)+(2*6)+(1*4)=119
119 % 10 = 9
So 119341-64-9 is a valid CAS Registry Number.

119341-64-9Relevant articles and documents

Naproxen sodium salt photochemistry in aqueous sodium dodecyl sulfate (SDS) ellipsoidal micelles

Valero,Sultimova, Natalya B.,Houston, Judith E.,Levin, Peter P.

, (2020/11/27)

The photochemistry and other properties of the anti-inflammatory drug (NSAID) naproxen (NP) in sodium dodecyl sulfate, SDS, micellar aqueous solutions at pH = 7 (NP is in anionic form) were studied. The large value of the partition coefficient (P) was obtained, logP = 2.7, showing that the most part of NP is localized in the micellar phase. The solubilization in SDS micelles results in NP fluorescence and photodegradation quantum yields decrease. The photoproducts 6-methoxy-2-(1-hydroxyethyl)-naphthalene and 6-methoxy-2-acetyl-naphthalene were found by gas chromatography/mass spectrometry (GC/MS). Both photoproducts were formed in SDS solution in significantly smaller amounts than in water. Small angle neutron scattering (SANS) showed that the presence of NP has small effect on the micellar structure. Only a slight decrease of the ionization degree of the micelle was observed by SANS, suggesting that NP was localized in the vicinity of micellar surface. The NP triplet excited state, hydrated electron, NP radical cation and some other relatively long lived intermediate were observed by laser flash photolysis of NP in micellar solution. The decay kinetics of these intermediates was different with respect to that in the homogeneous media. The reactivity of NP in SDS micellar environment was compared to that in the homogeneous media and the probable nature of the intermediate precursors of the final photoproducts are under the discussion.

Application of a heme-binding protein eluted from encapsulated biomaterials to the catalysis of enantioselective oxidation

Nagaoka, Hiroyuki

, p. 553 - 565 (2014/03/21)

A protein complex (PX) eluted from an encapsulated pea protein (PP) under aeration can be used as two types of biocatalysts: a polyethylene glycol (PEG) (1000/4000 = 2/1)-aggregated PX (AGPX) and a glutaraldehyde (GA)/compound- modified PX (CMPX). These biocatalysts have the following functional activities: AGPX can catalyze the oxidation of rac-1-(6-methoxynaphthalen-2-yl)ethanol (rac-1) to the corresponding ketone (~95% chemical yield) via the selective oxidation of (S)-(+)-1, leaving highly enantiopure (R)-(-)-1 (>99% ee; ~50% chemical yield); CMPX can catalyze the kinetic resolution of (S)-(+)-1 ((S)-naproxen precursor, >99% ee, ~50% chemical yield) via the selective oxidation of (R)-(-)-1 to the corresponding ketone. Both reactions occur in the absence of an added cofactor (e.g., NAD(P)) in aqueous media. The specific activities of AGPX and CMPX were determined to be 0.8 ± 0.03 mU (mean ± SD) and 0.6 ± 0.02 mU (mean ± SD), respectively, and the exact nature of the species engaged in the key reaction was consistent with that of a heme-binding protein (HBP), on the basis of an N-terminal sequence comparison, which showed 93% similarity with a 20.853 kDa hemophore HasA gene product [Pseudomonas fluorescens Pf-5, a plant commensal bacterium]. PP-HBP can be regenerated via successive asymmetric catalytic events using an incorporated iron electron-transfer system (Fe2+ a? Fe3+) in the presence of oxygen, a process seemingly similar to that utilized by hemoglobin. The use of a raw biomaterial as a PX-catalytic system with an incorporated redox cofactor for asymmetric oxidation overcomes the apparent difficulties in working with pure dehydrogenase enzyme/redox cofactor systems for biotransformation.

Scope of enantioselective Palladium(II)-catalyzed aerobic alcohol oxidations with (-)-sparteine

Mandal, Sunil K.,Jensen, David R.,Pugsley, Jacob S.,Sigman, Matthew S.

, p. 4600 - 4603 (2007/10/03)

Evaluation of the substrate scope for Pd(II)/ (-)-sparteine catalyzed aerobic oxidative kinetic resolution of secondary alcohols is disclosed. An improved system is found with use of tert-butyl alcohol solvent in which benzylic and aliphatic alcohols as well as alcohols containing olefins are effectively oxidatively resolved. For substrates that successfully undergo oxidative kinetic resolution, krel values are generally between 10 and 20. Successful scale-up of various substrates to 10-mmol scale is described. Extension to oxidative desymmetrization of 1,3-meso-diols is successful with enantiomeric excesses ranging from 78 to 85%.

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