119386-74-2

Basic information

• Product Name: 1H-IMidazole, 1-[2-(2,4-dichlorophenyl)-2-(3-thienylMethoxy)ethyl]-
• CAS NO: 119386-74-2
• Molecular Formula: C₁₆H₁₄Cl₂N₂OS
• Molecular Weight: 353.266
• Mol File: 119386-74-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-IMidazole, 1-[2-(2,4-dichlorophenyl)-2-(3-thienylMethoxy)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-IMidazole, 1-[2-(2,4-dichlorophenyl)-2-(3-thienylMethoxy)ethyl]-(119386-74-2)
• EPA Substance Registry System: 1H-IMidazole, 1-[2-(2,4-dichlorophenyl)-2-(3-thienylMethoxy)ethyl]-(119386-74-2)

Safety Data

• Hazardous Substances Data: 119386-74-2(Hazardous Substances Data)

Usage

Molecular structure

1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-(3-thienylMethoxy)ethyl]consists of an imidazole ring attached to a long hydrocarbon chain that contains a 2,4-dichlorophenyl group and a 3-thienylMethoxy group.

Biological activity

The presence of the imidazole ring, which is a common structural motif in many biologically active compounds, suggests that 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-(3-thienylMethoxy)ethyl]may have applications in pharmaceuticals.

Unique properties

The specific substitution pattern of the phenyl and thienylMethoxy groups may provide the compound with unique properties or reactivity.

Building block for synthesis

The compound may be a valuable building block for the synthesis of other more complex molecules.

Upstream product

• 46503-52-0 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanone 
• 2631-72-3 2,4-dichlorophenacyl bromide 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 
• 34846-44-1 3-Bromomethylthiophene 
• 24155-42-8 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol 

Relevant articles and documents

Novel BuChE-IDO1 inhibitors from sertaconazole: Virtual screening, chemical optimization and molecular modeling studies

In our effort towards the identification of novel BuChE-IDO1 dual-targeted inhibitor for the treatment of Alzheimer's disease (AD), sertaconazole was identified through a combination of structure-based virtual screening followed by MM-GBSA rescoring. Preliminary chemical optimization was performed to develop more potent and selective sertaconazole analogues. In consideration of the selectivity and the inhibitory activity against target proteins, compounds 5c and 5d were selected for the next study. Further modification of compound 5c led to the generation of compound 10g with notably improved selectivity towards BuChE versus AChE. The present study provided us with a good starting point to further design potent and selective BuChE-IDO1 inhibitors, which may benefit the treatment of late stage AD.

1-Aryl-2-(1-imidazolyl) alkyl ethers and thioethers

Novel 1-aryl-2-(1-imidazolyl)alkyl ethers and thioethers having anti-fungal properties are disclosed.