119752-02-2Relevant academic research and scientific papers
Direct aldol reactions catalyzed by a heterogeneous guanidinium salt/proline system under solvent-free conditions
Martinez-Castaneda, Angel,Poladura, Belen,Rodriguez-Solla, Humberto,Concellon, Carmen,Del Amo, Vicente
, p. 3032 - 3035 (2011)
The combined activity of (S)-proline and an achiral cocatalyst (a TBD-derived guanidinium salt) allow direct aldol reactions to be carried out with high diastereoselectivity and enantioselectivity under solvent-free conditions with a rather simple reactio
Gelatin protein-mediated direct Aldol reaction
Kühbeck, Dennis,Bachl, Jürgen,Sch?n, Eva-Maria,Gotor-Fernández, Vicente,Díaz Díaz, David
, p. 574 - 580 (2014)
Gelatin protein was found to catalyze the aldol reaction between cyclohexanone and different aromatic aldehydes under mild reaction conditions. The aldol additions carried out in DMSO at 37 yielded the addition products with moderate diastereoselectivitie
Asymmetric organocatalytic direct aldol reactions of cyclohexanone with aldehydes in brine
Huang, Wen-Ping,Chen, Jia-Rong,Li, Xin-Yong,Cao, Yi-Ju,Xiao, Wen-Jing
, p. 208 - 213 (2007)
Organocatalytic asymmetric direct aldol reactions in brine with high diastereo- and enantioselectivities, using a readily available bifunctional amide catalyst, were developed.
Highly diastereoselective preparation of aldol products using new functionalized allylic aluminum reagents
Shen, Zhi-Liang,Peng, Zhihua,Yang, Chun-Ming,Helberg, Julian,Mayer, Peter,Marek, Ilan,Knochel, Paul
, p. 956 - 959 (2014)
Chloro-substituted triethylsilyl enol ethers derived from cyclohexanone and related ketones are converted with aluminum powder in the presence of indium trichloride to functionalized allylic aluminum reagents which represent a new type of synthetic equiva
Rationally designed organocatalyst for direct asymmetric aldol reaction in the presence of water
Wang, Chao,Jiang, Yi,Zhang, Xiao-xia,Huang, Yi,Li, Bo-gang,Zhang, Guo-lin
, p. 4281 - 4285 (2007)
A rationally designed organocatalyst for direct asymmetric aldol reaction in the presence of water has been developed. High yield (up to 99%), diastereoselectivity (up to 99:1) and enantioselectivity (up to 97%) were obtained under optimal conditions.
Highly efficient threonine-derived organocatalysts for direct asymmetrie aldol reactions in water
Wu, Xiaoyu,Jiang, Zhaoqin,Shen, Han-Ming,Lu, Yixin
, p. 812 - 816 (2007)
The introduction of siloxy groups at the hydroxy function of natural threonine resulted in efficient hydrophobic organocatalysts, which could efficiently catalyze the direct aldol reactions of both cyclic and acyclic ketones with aromatic aldehydes in wat
Self-assembled Polydiacetylene Nanoribbons for Semi-heterogeneous and Enantioselective Organocatalysis of Aldol Reactions in Water
Hoang, Minh-Duc,Kumar, Ramar Arun,Buisson, David A.,Ling, Wai Li,Gravel, Edmond,Doris, Eric
, p. 1156 - 1160 (2020)
We report the synthesis, characterization, and supra-molecular assembly of novel diacetylene amphiphilic units bearing a chiral proline-derived head group. In water, these amphiphiles self-assemble into twisted ribbons that are photo-polymerized to afford
Enantioselective aldol reaction of trimethoxysilyl enol ethers with aldehydes catalyzed by p-Tol-BINAP·AgF complex
Yanagisawa,Nakatsuka,Asakawa,Kageyama,Yamamoto
, p. 69 - 72 (2001)
New catalytic asymmetric Mukaiyama-type aldol reaction using trimethoxysilyl enol ethers was achieved using p-Tol-BINAP·AgF complex as a catalyst. High syn- and enantioselectivities were obtained both from the E- and Z-silyl enol ethers.
Polydopamine - An organocatalyst rather than an innocent polymer
Mrowczynski, Radoslaw,Bunge, Alexander,Liebscher, Juergen
, p. 8647 - 8653 (2014)
Polydopamine (PDA) is easily available by oxidation of dopamine and is widely used for persistent coatings of various materials. It is hitherto considered to be inert in many interesting biomedical and other applications. Results presented here, reveal an unexpected behavior of polydopamine as an organocatalyst in direct aldol reactions under mild conditions. Evidence was found for dual catalysis making use of amino and phenolic hydroxy groups found in PDA. Thus scientists must be aware that PDA is not an innocent polymer and can cause unwanted side effects in important applications, such as in biomedicine or as supports in catalysis.
An efficient ionic liquid additive for proline-catalyzed direct asymmetric aldol reactions between cyclic ketones and aromatic aldehydes
Qian, Yunbo,Zheng, Xin,Wang, Xu,Xiao, Shiyong,Wang, Yongmei
, p. 576 - 577 (2009)
An ionic liquid [EMIm][CF3COO] proved to be an efficient additive for proline-catalyzed direct asymmetric aldol reactions between cyclic ketones and aromatic aldehydes in [BMIm]BF4 at room temperature. Corresponding aldol products in
