119757-57-2

Basic information

• Product Name: (E/E)-1-[4-(2-Chloroethoxy)phenyl]-1-(4-hydroxyphenyl)-2-phenyl-1-butene
• Synonyms: 4-[1-[4-(2-chloroethoxy)phenyl]-2-phenyl-1-butenyl]-phenol;(E/Z)-1-[4-(2-Chloroethoxy)phenyl]-1-(4-hydroxyphenyl)-2-phenyl-1-butene
• CAS NO: 119757-57-2
• Molecular Formula: C24H23ClO2
• Molecular Weight: 378.89
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 119757-57-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 125-128°C
• Boiling Point: 509°C at 760 mmHg
• Flash Point: 261.6°C
• Appearance: /
• Density: 1.163g/cm³
• Vapor Pressure: 5.55E-11mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (E/E)-1-[4-(2-Chloroethoxy)phenyl]-1-(4-hydroxyphenyl)-2-phenyl-1-butene(CAS DataBase Reference)
• NIST Chemistry Reference: (E/E)-1-[4-(2-Chloroethoxy)phenyl]-1-(4-hydroxyphenyl)-2-phenyl-1-butene(119757-57-2)
• EPA Substance Registry System: (E/E)-1-[4-(2-Chloroethoxy)phenyl]-1-(4-hydroxyphenyl)-2-phenyl-1-butene(119757-57-2)

Safety Data

• Hazardous Substances Data: 119757-57-2(Hazardous Substances Data)

Usage

Chemical Properties

Brown Foam

Uses

An intermediate in the syntheis of a metabolite of the anti-cancer drug Tamoxifen

InChI:InChI=1/C24H23ClO2/c1-2-23(18-6-4-3-5-7-18)24(19-8-12-21(26)13-9-19)20-10-14-22(15-11-20)27-17-16-25/h3-15,26H,2,16-17H2,1H3/b24-23+

Upstream product

• 1215295-57-0 (4-(2-chloroethoxy)phenyl)(4-hydroxyphenyl)methanone 
• 93-55-0 1-phenyl-propan-1-one 
• 622-86-6 2-chloroethoxybenzene 
• 108-95-2 phenol 
• 36603-49-3 4-(tetrahydropyran-2'-yloxy)-1-bromobenzene 
• 103628-22-4 1--2-phenyl-butan-1-one 
• 1032008-64-2 C₂₉H₃₃ClO₄ 
• 114031-67-3 [4-(4-hydroxybenzoyl)phenyl]-2,2-dimethyl propanoate 
• 36854-57-6 2-Phenylbutyryl chloride 
• 90-27-7 2-Phenylbutyric acid 

Downstream Products

• 114828-90-9 trans-Endoxifen 
• 1350660-46-6 (E/Z)-4-(1-{4-[2-(hexylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenol 
• 1331643-32-3 Tam-N₃ 
• 174592-47-3 trans 4-hydroxytamoxifen 
• 103628-14-4 (Z)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene 
• 103628-15-5 (E)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene 

Relevant articles and documents

High affinity fluorescent ligands for the estrogen receptor

Fluorescent binders of the estrogen receptor (ER) are used in binding assays and in detection or imaging studies. However, fluorescence labelling of ER ligands usually leads to substantial decreases in binding affinity. In this study, we describe the deve

Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator

We designed and synthesized an estrogen receptor (ER) down-regulator (5), which is a derivative of tamoxifen with a long alkyl side chain. Compound 5 effectively reduced ER protein levels in MCF-7 cells and had an antagonistic effect.

ENDOXIFEN METHODS AND COMPOSITIONS

The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of breast cancer and other breast