1206970-19-5Relevant academic research and scientific papers
SUBSTITUTED TRIAZINONES AS THYROID HORMONE RECEPTOR AGONISTS
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Paragraph 00259; 00260, (2021/07/24)
The application relates to a compound of Formula (I') or (I), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of thyroid hormone receptors, a pharmaceutical composition comprising a compound of Formula (I') or (I), and a method of treating or preventing a disease or disorder regulated by thyroid hormone.
Fragment-Linking Approach Using 19F NMR Spectroscopy to Obtain Highly Potent and Selective Inhibitors of β-Secretase
Jordan, John B.,Whittington, Douglas A.,Bartberger, Michael D.,Sickmier, E. Allen,Chen, Kui,Cheng, Yuan,Judd, Ted
, p. 3732 - 3749 (2016/05/19)
Fragment-based drug discovery (FBDD) has become a widely used tool in small-molecule drug discovery efforts. One of the most commonly used biophysical methods in detecting weak binding of fragments is nuclear magnetic resonance (NMR) spectroscopy. In part
SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
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Paragraph 0391, (2015/07/02)
Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.
Expedient synthesis of cis- and trans-3-aminocyclobutanecarboxylic acids
Radchenko, Dmytro S.,Tkachenko, Anton,Grygorenko, Oleksandr O.,Komarov, Igor V.
, p. 1644 - 1649 (2011/06/23)
An expedient approach to cis- and trans-3-aminocyclobutanecarboxylic acids was developed starting from 1,1-cyclobutanedicarboxylic acid. Stereochemistry of the title compounds was established by nuclear Overhauser effect spectroscopy experiments.
