1207-75-6Relevant articles and documents
Synthesis, crystal structure, spectral and DFT studies of potent isatin derived metal complexes
Sumrra, Sajjad Hussain,Atif, Aftab Hussain,Zafar, Muhammad Naveed,Khalid, Muhammad,Tahir, Muhammad Nawaz,Nazar, Muhammad Faizan,Nadeem, Muhammad Arif,Braga, Ataualpa A.C.
, p. 110 - 120 (2018)
The isatin-core in compounds offers exciting perspectives in medicinal and pharmacological research. The present study reports the successful development of new isatin-core transition metal based anti-bacterial complexes via conventional refluxing method.
Ketoserin intermediate and preparation method of ketoserin
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Paragraph 0045-0046; 0048-0050, (2021/01/15)
The invention discloses a preparation method of a ketoserin intermediate 2, 3-dihydro-5H-oxazolo[2, 3-B]quinazoline-5-ketone and a preparation method of ketoserin, and the reaction equation of the preparation method of the ketoserin intermediate 2, 3-dihydro-5H-oxazolo[2, 3-B]quinazoline-5-ketone is shown in the specification: in the reaction, sodium carbonate and acetonitrile are used, no catalyst is added, inorganic salt is removed through hot filtration after the reaction, filtrate is evaporated to dryness, acetonitrile is recycled, and an intermediate 04, namely the ketoserin intermediate2, 3-dihydro-5H-oxazolo[2, 3-B]quinazoline-5-ketone, is obtained. The method is simple and convenient to operate, lower in cost, better in product character and more beneficial to synthesis of a finalproduct.
4-Hydroxy-2-quinolones 173. 1-R-3-(2-diethylamino- ethyl)-1H-quinazoline- 2,4-dione hydrochlorides as potential local anesthetic agents
Ukrainets,Kravtsova,Tkach,Mamchur,Kovalenko, E. Yu.
experimental part, p. 96 - 105 (2010/09/04)
Different variants of the preparation and procedures in the synthesis of a series of 1-R-3-(2-dialkyl-aminoethyl)-1H-quinazoline-2,4-dione hydrochlorides having a structural similarity to the 4-hydroxy-2-quinolinone anesthetic chinoxicaine are discussed. A comparative analysis of the biological properties of the synthesized compounds and the known local anesthetics chinoxicaine and lidocaine is reported.