52727-44-3

Basic information

• Product Name: 2,3-DIHYDRO-5H-OXAZOLO[2,3-B]QUINAZOLIN-5-ONE
• Synonyms: 2,3-DIHYDRO-5H-OXAZOLO[2,3-B]QUINAZOLIN-5-ONE;2,3-Dihydro-oxazolo[2,3-b]quinazolin-5-one;2H-oxazolo[2,3-b]quinazolin-5(3H)-one
• CAS NO: 52727-44-3
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.18
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Quinazolines
• Mol File: 52727-44-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 160-163 °C(lit.)
• Boiling Point: 330.046 °C at 760 mmHg
• Flash Point: 153.407 °C
• Appearance: /
• Density: 1.47
• Vapor Pressure: 0.000171mmHg at 25°C
• Refractive Index: 1.719
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,3-DIHYDRO-5H-OXAZOLO[2,3-B]QUINAZOLIN-5-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-5H-OXAZOLO[2,3-B]QUINAZOLIN-5-ONE(52727-44-3)
• EPA Substance Registry System: 2,3-DIHYDRO-5H-OXAZOLO[2,3-B]QUINAZOLIN-5-ONE(52727-44-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 52727-44-3(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-5H-oxazolo[2,3-b]quinazolin-5-one is a heterocyclic chemical compound with the molecular formula C9H6N2O2. It is a bicyclic compound that contains both an oxazole and a quinazolinone ring. 2,3-Dihydro-5H-oxazolo[2,3-b]quinazolin-5-one has potential medicinal properties, as it has been studied for its potential anticonvulsant and neuroprotective effects. It has also been investigated for its potential anti-cancer and anti-inflammatory properties. 2,3-Dihydro-5H-oxazolo[2,3-b]quinazolin-5-one has the potential for further research and development for various medical applications.

InChI:InChI=1/C10H8N2O2/c13-9-7-3-1-2-4-8(7)11-10-12(9)5-6-14-10/h1-4H,5-6H2

Upstream product

• 13908-44-6 2-<3-(2-chloroethyl)ureido>benzoic acid 
• 1207-75-6 2,4-Dioxo-3-(2-hydroxyethyl)-1,2,3,4-tetrahydroquinazoline 
• 83846-67-7 methyl 2-((ethoxycarbonyl)amino)benzoate 
• 1885-29-6 anthranilic acid nitrile 
• 134-20-3 2-carbomethoxyaniline 
• 118-92-3 anthranilic acid 
• 77093-93-7 2-(2-chloroethylamino)-4H-<3,1>benzoxazin-4-one 
• 77093-94-8 2-(2-chloroethylamino)-4H-<3,1>benzoxazin-4-one hydrochloride 
• 77189-70-9 2-<3-(2-cloroethyl)ureido>benzonitrile 
• 28144-70-9 anthranilic acid amide 
• 120627-65-8 2-benzylthio-Δ²-1,3-oxazoline 
• 1943-83-5 2-chloroethyl isothiocyanate 
• 77093-92-6 methyl 2-<3-(2-chloroethyl)ureido>benzoate 
• 28175-87-3 2-(2-chloroethyl ureido)benzamide 

Relevant articles and documents

Ketoserin intermediate and preparation method of ketoserin

The invention discloses a preparation method of a ketoserin intermediate 2, 3-dihydro-5H-oxazolo[2, 3-B]quinazoline-5-ketone and a preparation method of ketoserin, and the reaction equation of the preparation method of the ketoserin intermediate 2, 3-dihydro-5H-oxazolo[2, 3-B]quinazoline-5-ketone is shown in the specification: in the reaction, sodium carbonate and acetonitrile are used, no catalyst is added, inorganic salt is removed through hot filtration after the reaction, filtrate is evaporated to dryness, acetonitrile is recycled, and an intermediate 04, namely the ketoserin intermediate2, 3-dihydro-5H-oxazolo[2, 3-B]quinazoline-5-ketone, is obtained. The method is simple and convenient to operate, lower in cost, better in product character and more beneficial to synthesis of a finalproduct.

VMAT INHIBITORY COMPOUNDS

Disclosed herein are compounds that bind to the vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions comprising those compounds, and methods of treatment using said compounds and pharmaceutical compositions.

Reactions of Anthranilamide with Isocyanates: A New Facile Synthesis of 2,3-Dihydro-5H-oxazoloquinazolin-5-one and 3,4-dihydro-2H,6H-oxazinoquinazolin-6-one

2,3-Dihydro-5H-oxazoloquinazolin-5-one 5a was synthesized from anthranilamide 1 and 2-chloroethyl isocyanate either by a direct reflux in methanol, or by stirring at room temperature in acetonitrile leading to the intermediate, 2-(2-chloroethyl ureido)benzamide 6a which was subsequently cyclized on heating with an organic base.However, when compound 6a was refluxed with concentrated hydrochloric acid, it furnished 3-(2-chloroethyl)-2,4-dioxo-1H,3H-quinazoline 2a in a good yields. 3,4-Dihydro-2H,6H-oxazinoquinazolin-6-one 5b, 3-(3-chloropropyl)-2,4-dioxo-1H,3H-quinazoline 2b and 2-(3-chloropropyl ureido)benzamide 6b were obtained similarly from 1 and 3-chloropropyl isocyanate.