52727-44-3

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dihydro-5H-oxazolo[2,3-b]quinazolin-5-one is used as a potential therapeutic agent for its anticonvulsant properties, making it a candidate for the treatment of seizure disorders. Its neuroprotective effects also suggest its utility in conditions involving neuronal damage or degeneration.
Used in Oncology:
In the field of oncology, 2,3-Dihydro-5H-oxazolo[2,3-b]quinazolin-5-one is utilized as a potential anti-cancer agent. Its mechanism of action may involve the inhibition of cancer cell growth and the induction of apoptosis, offering a novel approach to cancer treatment.
Used in Inflammation Management:
2,3-Dihydro-5H-oxazolo[2,3-b]quinazolin-5-one is employed as an anti-inflammatory agent, which could be beneficial in the treatment of various inflammatory conditions. Its effects on inflammatory pathways may help in reducing inflammation and associated symptoms.
Used in Research and Development:
2,3-Dihydro-5H-oxazolo[2,3-b]quinazolin-5-one serves as a subject of research and development in the pharmaceutical and biotechnology sectors. Its diverse potential applications make it a valuable compound for exploring new drug discovery and therapeutic strategies.

InChI:InChI=1/C10H8N2O2/c13-9-7-3-1-2-4-8(7)11-10-12(9)5-6-14-10/h1-4H,5-6H2

Upstream product

• 75-21-8 oxirane 
• 607-69-2 2-chloro-4-hydroxy-quinazoline 
• 72115-31-2 2-(aziridine-1-carbonylamino)-benzoic acid methyl ester 
• 106-93-4 ethylene dibromide 
• 86-96-4 quinazoline-2,4-diol 
• 42865-19-0 2-bromoethyl isocyanate 
• 134-20-3 2-carbomethoxyaniline 
• 5081-87-8 3-(2-chloro-ethyl)-1H-quinazoline-2,4-dione 
• 13908-44-6 2-<3-(2-chloroethyl)ureido>benzoic acid 
• 77093-93-7 2-(2-chloroethylamino)-4H-<3,1>benzoxazin-4-one 
• 1943-83-5 2-chloroethyl isothiocyanate 
• 28144-70-9 anthranilic acid amide 
• 118-92-3 anthranilic acid 
• 120627-65-8 2-benzylthio-Δ²-1,3-oxazoline 

Relevant academic research and scientific papers

Ketoserin intermediate and preparation method of ketoserin

The invention discloses a preparation method of a ketoserin intermediate 2, 3-dihydro-5H-oxazolo[2, 3-B]quinazoline-5-ketone and a preparation method of ketoserin, and the reaction equation of the preparation method of the ketoserin intermediate 2, 3-dihydro-5H-oxazolo[2, 3-B]quinazoline-5-ketone is shown in the specification: in the reaction, sodium carbonate and acetonitrile are used, no catalyst is added, inorganic salt is removed through hot filtration after the reaction, filtrate is evaporated to dryness, acetonitrile is recycled, and an intermediate 04, namely the ketoserin intermediate2, 3-dihydro-5H-oxazolo[2, 3-B]quinazoline-5-ketone, is obtained. The method is simple and convenient to operate, lower in cost, better in product character and more beneficial to synthesis of a finalproduct.

Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter

Methamphetamine, a human vesicular monoamine transporter 2 (VMAT2) substrate, releases dopamine, serotonin, and norepinephrine from vesicles into the cytosol of presynaptic neurons and induces reverse transport by the monoamine transporters to increase ex

VMAT INHIBITORY COMPOUNDS

Disclosed herein are compounds that bind to the vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions comprising those compounds, and methods of treatment using said compounds and pharmaceutical compositions.

A new and rapid access to homochiral 2,3-dihydro-oxazolo[2,3-b]quinazolin-5-ones

Starting from homochiral 1,3-oxazolidine-2-thiones 1, a two-step sequence led to homotopic 2,3-dihydro-oxazolo[2,3-b]quinazolin-5-one derivatives 3. The sequence was developed and studied regarding its scope and limitations.

Reactions of Anthranilamide with Isocyanates: A New Facile Synthesis of 2,3-Dihydro-5H-oxazoloquinazolin-5-one and 3,4-dihydro-2H,6H-oxazinoquinazolin-6-one

2,3-Dihydro-5H-oxazoloquinazolin-5-one 5a was synthesized from anthranilamide 1 and 2-chloroethyl isocyanate either by a direct reflux in methanol, or by stirring at room temperature in acetonitrile leading to the intermediate, 2-(2-chloroethyl ureido)benzamide 6a which was subsequently cyclized on heating with an organic base.However, when compound 6a was refluxed with concentrated hydrochloric acid, it furnished 3-(2-chloroethyl)-2,4-dioxo-1H,3H-quinazoline 2a in a good yields. 3,4-Dihydro-2H,6H-oxazinoquinazolin-6-one 5b, 3-(3-chloropropyl)-2,4-dioxo-1H,3H-quinazoline 2b and 2-(3-chloropropyl ureido)benzamide 6b were obtained similarly from 1 and 3-chloropropyl isocyanate.

Reactions of o-Aminonitriles with Isocyanates. 1. A Two-Step Synthesis of 2,6-Dihydroimidazoquinazolin-5-(3H)one

The reaction of anthranilonitrile with 2-chloroethyl isocyanate yields 2-benzonitrile (6) which, upon heating, or treatment with base, undergoes a double cyclization to form 2,6-dihydroimidazoquinazolin-5-(3H)one (8) in excellent yield.When heated with hydrochloric acid, 6 is converted initially into 2-(2-chloroethylamino)-4H-benzoxazin-4-one (18) and further into 3-(2-chloroethyl)-2,4-(1H,3H)quinazolinedione (15).The acid-catalyzed reaction of 2,3-dihydro-5H-oxazoloquinazolin-5-one (14) with nucleophilic reagents yields 3-substituted 2,4-(1H,3H)quinazolinediones.