1215298-35-3

Basic information

• Product Name: methyl 2-ethoxy-1-({2′-[1-(phenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl}methyl)-1H-benzimidazole-7-carboxylate
• Synonyms: methyl 2-ethoxy-1-({2′-[1-(phenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl}methyl)-1H-benzimidazole-7-carboxylate
• CAS NO: 1215298-35-3
• Molecular Weight: 544.613
• Mol File: 1215298-35-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl 2-ethoxy-1-({2′-[1-(phenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl}methyl)-1H-benzimidazole-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-ethoxy-1-({2′-[1-(phenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl}methyl)-1H-benzimidazole-7-carboxylate(1215298-35-3)
• EPA Substance Registry System: methyl 2-ethoxy-1-({2′-[1-(phenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl}methyl)-1H-benzimidazole-7-carboxylate(1215298-35-3)

Safety Data

• Hazardous Substances Data: 1215298-35-3(Hazardous Substances Data)

Upstream product

• 892505-90-7 methyl 1-(4-bromobenzyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 
• 28386-90-5 5-benzyl-1-phenyl-1H-tetrazole 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 150058-27-8 2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester 
• 480-63-7 mesitylenecarboxylic acid 
• 168265-56-3 1-benzyl-5-(4'-methyl-[1,1'-biphenyl]-2-yl)-1H-tetrazole 
• 38612-13-4 4-bromobenzyl benzoate 
• 106-38-7 para-bromotoluene 
• 1485-70-7 N-benzylbenzamide 
• 98-88-4 benzoyl chloride 
• 100-46-9 benzylamine 
• 1215298-30-8 methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-nitrobenzoate 
• 1307853-80-0 methyl 2-(N-tert-butoxycarbonyl-N-{(2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl)methyl}amino)-3-nitrobenzoate 
• 78-09-1 orthocarbonic acid tetraethyl ester 

Downstream Products

• 1307853-85-5 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 1-({4-[2-(1-benzyl-1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-2-ethoxy-1H-1,3-benzodiazole-7-carboxylate 
• 145040-37-5 candesartan cilexetil 

Relevant articles and documents

Convergent Synthesis of Angiotensin II Receptor Blockers through C-H Arylation of 1-Benzyl-5-phenyl-1 H -tetrazole with Functionalized Aryl Bromides

Highly convergent synthesis of angiotensin II receptor blockers has been accomplished by means of late-stage C-H arylation using functionalized aryl bromides. C-H arylation of 1-benzyl-5-phenyl-1 H -tetrazole with aryl bromides carrying methyl 2-ethoxyben

DEPROTECTION METHOD FOR TETRAZOLE COMPOUND

The present invention relates to a method of deprotecting a tetrazole compound, useful as an intermediate for angiotensin II receptor blockers, and provides a novel production method of angiotensin II receptor blockers. Provided is a production method of a compound represented by the formula [3] or [4] or a salt thereof, including (i) reducing a compound represented by the formula [1] or [2] or a salt thereof in the presence of a metal catalyst and an alkaline earth metal salt, or (ii) reacting the compound with a particular amount of Br?nsted acid: wherein each symbol is as defined in the present specification.

Efficient catalytic system for Ru-catalyzed C-H arylation and application to a practical synthesis of a pharmaceutical

A series of K salts of sulfonic acids have been tested as a cocatalyst for Ru-catalyzed C-H arylation. Among them, K 2, 4, 6-trimethylbenzenesulfonate (TMBSK) was found to be most active, and generality of the reaction was confirmed for a variety of nitrogen-containing heterocycles to give corresponding functionalized biaryls in high yields. The present methodology was applied to a practical synthesis of Candesartan Cilexetil.