1236211-29-2

Upstream product

• 540-38-5 p-Iodophenol 
• 620-18-8 3-hydroxystyrene 
• 2454-30-0 3-vinylphenyl acetate 
• 33527-94-5 4-acetoxyiodobenzene 
• 2628-16-2 p-acetoxystyrene 
• 6304-89-8 3-acetoxybenzoic acid 

Downstream Products

• 63877-76-9 (E)-4-<2-(3-hydroxyphenyl)ethenyl>phenol 

Relevant academic research and scientific papers

Galloyl esters of trans-stilbenes are inhibitors of FASN with anticancer activity on non-small cell lung cancer cells

Fatty acid synthase (FASN) is a lipogenic enzyme that is selectively upregulated in malignant cells. There is growing consensus on the oncogenicity of FASN-driven lipogenesis and the potential of FASN as a druggable target in cancer. Here, we report the synthesis and FASN inhibitory activities of two novel galloyl esters of trans-stilbene EC1 and EC5. Inhibition of FASN was accompanied by a loss in AKT activation and profound apoptosis in several non-small cell lung cancer (NSCLC) cells at the growth inhibitory concentrations of EC1 and EC5. Both FASN and phospho-AKT levels were concurrently downregulated. However, addition of a lipid concentrate to the treated cells reinstated cell viability and reversed the loss of FASN and AKT protein levels, thus recapitulating the causal relationship between FASN inhibition and the loss in cell viability.

MOLECULARLY IMPRINTED POLYMERS

The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.