2454-30-0

Upstream product

• 591-20-8 3-Bromophenol 
• 108-24-7 acetic anhydride 
• 74-85-1 ethene 
• 35065-86-2 3-bromophenyl acetate 
• 620-18-8 3-hydroxystyrene 
• 100-83-4 meta-hydroxybenzaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 42861-71-2 3-iodophenylacetate 
• 34231-78-2 3-formylphenyl acetate 
• 41908-11-6 3-acetylbenzaldehyde 
• 74-95-3 1,1-dibromomethane 
• 1026420-83-6 1-(1-bromoethyl)-3,5-diacetoxybenzene 

Downstream Products

• 6554-98-9 trans-4-Hydroxystilbene 
• 1236211-29-2 (E)-3-(4-acetoxystyryl)phenyl acetate 
• 93022-30-1 Trans-acetic acid 4-styrylphenyl ester 
• 155222-48-3 5-vinyl-1,3-phenylene diacetate 

Relevant academic research and scientific papers

3 - Acetoxystyrene production

[Problem] industrially easily available raw material can be used, or the deleterious reaction reagent, which does not require special equipment, new 3 - acetoxystyrene manufacturing method. [Solution] the following i) - iii) comprising the steps of, manuf

METHOD FOR PRODUCING 3-ACETOXYSTYRENE

PROBLEM TO BE SOLVED: To provide an industrially advantageous production method for 3-acetoxystyrene. SOLUTION: The present invention provides a method for producing 3-acetoxystyrene represented by the formula (2), including the Heck reaction of 3-acetoxy

Galloyl esters of trans-stilbenes are inhibitors of FASN with anticancer activity on non-small cell lung cancer cells

Fatty acid synthase (FASN) is a lipogenic enzyme that is selectively upregulated in malignant cells. There is growing consensus on the oncogenicity of FASN-driven lipogenesis and the potential of FASN as a druggable target in cancer. Here, we report the synthesis and FASN inhibitory activities of two novel galloyl esters of trans-stilbene EC1 and EC5. Inhibition of FASN was accompanied by a loss in AKT activation and profound apoptosis in several non-small cell lung cancer (NSCLC) cells at the growth inhibitory concentrations of EC1 and EC5. Both FASN and phospho-AKT levels were concurrently downregulated. However, addition of a lipid concentrate to the treated cells reinstated cell viability and reversed the loss of FASN and AKT protein levels, thus recapitulating the causal relationship between FASN inhibition and the loss in cell viability.

Combining photoredox and silver catalysis for azidotrifluoromethoxylation of styrenes

The first example of an azidotrifluoromethoxylation of styrenes has been achieved by synergistic visible-light-mediated photoredox and silver catalysis. Trifluoromethyl arylsulfonate (TFMS) and the Zhdankin reagent were used as the trifluoromethoxylation reagent and the azide source, respectively. A good functional group tolerance and mild reaction conditions of this method are applicable to late-stage azidotrifluoromethoxylation of complex small molecules. Furthermore, the mechanistic investigations indicate the single-electron transfer involved in the reaction.

Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched Aldehydes

Two tandem flow chemistry processes have been developed. A single palladium-catalysed Heck reaction with ethylene gas provides an efficient synthesis for functionalised styrenes. Through further elaboration the catalyst becomes multi-functional and performs a second Heck reaction providing a single continuous process for the synthesis of unsymmetrical stilbenes. In addition, the continuous, rhodium-catalysed, hydroformylation of styrene derivatives with syngas affords branched aldehydes with good selectivity. Incorporation of an in-line aqueous wash and liquid-liquid separation allowed for the ethylene Heck reaction to be telescoped into the hydroformylation step such that a single flow synthesis of branched aldehydes directly from aryl iodides was achieved. The tube-in-tube semi-permeable membrane-based gas reactor and liquid-liquid separator both play an essential role in enabling these telescoped flow processes.

The continuous-flow synthesis of styrenes using ethylene in a palladium-catalysed heck cross-coupling reaction

We report a palladium-catalysed ethylene Heck reaction for the vinylation of aryl iodides using a tube-in-tube gas-liquid reactor. The flow process afforded various styrenes in short reaction times, employing moderate ethylene pressure. Georg Thieme Verlag Stuttgart · New York.

PROCESS FOR THE PREPARATION OF STILBENE DERIVATIVES

A novel process for the preparation of resveratrol and piceatannol and esters thereof involving a Heck type reaction is disclosed. Also disclosed are novel intermediates in that process.

Method of producing styrene derivatives

A method of producing styrene derivatives expressed the general formula (2) by reacting a benzaldehyde derivative expressed by the general formula (1) with dibromomethane under the existence of zinc metal as well as an active chloride for producing various types of oxystyrene which are polymerized monomers as a photoresist material used in a high density integrated circuit process from easily available materials which also can easily be handled: (wherein R indicates a an alkyl group, alkoxyalkyl group, an alkylcarbonyl group, an alkoxycarbonyl group, a 5 or 6-atom heterocylclic groups, or an alkylsilyl group); (wherein R indicates any of the same substituents as those described above.)