123826-83-5

Upstream product

• 629-11-8 1,6-hexanediol 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 54314-84-0 1-[(3-bromopropoxy)methyl]-benzene 
• 347885-68-1 4-bromo-1-tosylpiperidine 
• 4119-41-9 1-iodo-3-phenylpropan 
• 100-52-7 benzaldehyde 

Downstream Products

• 108-88-3 toluene 

Relevant academic research and scientific papers

Monobenzylation of 1,n-diols via dibutylstannylene intermediates

Symmetrical primary 1,n-diols, HO(CH2)(n)OH, of any chain length from n = 2-10, can be selectively monobenzylated via sequential treatment with dibutyltin oxide and benzyl bromide.

An efficient and convenient method for the direct conversion of alkyl silyl ethers into the corresponding alkyl ethers catalyzed by iron(III) chloride

Various alcohol silyl ethers were readily and efficiently transformed into the corresponding alkyl ethers in high yields by the use of aldehydes combined with triethylsilane in the presence of a catalytic amount of iron(III) chloride. Georg Thieme Verlag Stuttgart.

Enantioselective Radical Addition/Cross-Coupling of Organozinc Reagents, Alkyl Iodides, and Alkenyl Boron Reagents

A hybrid transition-metal/radical process is described that results in the addition of organozinc reagents and alkyl halides across alkenyl boron reagents in an enantioselective catalytic fashion. The reaction can be accomplished both intermolecularly and intramolecularly, providing useful product yields and high enantioselectivities in both manifolds.

Nickel-catalyzed cross-coupling of unactivated alkyl halides using bis(pinacolato)diboron as reductant

The use of bis(pinacolato)diboron as the terminal reductant allows the efficient Ni-catalyzed coupling of unactivated secondary and primary alkyl halides, generating the C(sp3)-C(sp3) coupling products in good yields. The mild cataly

Active site plasticity of a critical enzyme from Mycobacterium tuberculosis

3-Deoxy-d-arabino-heptulosonate 7-phosphate synthase is an important biosynthetic enzyme in Mycobacterium tuberculosis and a potential drug target. We describe the synthesis, evaluation and docking of inhibitors with various chain lengths, which provide insight into the plasticity of the active site for inhibitor binding.

Intramolecular benzyl-benzyl interactions in protonated benzyl diethers in the gas phase. Effects of internal hydrogen bonding

Protonated molecules of a variety of benzyl diethers, produced by chemical ionization (CI), undergo a unique rearrangement yielding relatively abundant mlz 181 C14H13+ ions, both in the ion source and under collision-induc

Highly selective Silver(I) oxide mediated monoprotection of symmetrical diols

Treatment of symmetrical diol with Ag2O and alkyl halide gave the monoprotected derivative in good to excellent yield.

Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' group

In this study, structure-based drug design of matrix metalloproteinase inhibitors [human fibroblast collagenase (HFC), human fibroblast stromelysin (HFS), and human neutrophil collagenase (HNC)] was utilized in the development of potent hydroxamates which

SELECTIVE MONOETHERIFICATION AND MONOESTERIFICATION OF DIOLS AND DIACIDS UNDER PHASE-TRANSFER CONDITIONS

Research on the selectivity of etherification reactions of diols and esterification reactions of diacids by alkyl halides under phase-transfer catalysis has shown that under such conditions, selectivity of monoetherification increases in the order prim sec tert diols, though overall yield of monoether decreases from sec to tert diols.Monoesterification of diacids was accomplished with a high degree of selectivity.Optimal extraction of diols and diacids was found to correspond in general to chain lengths of around 5 carbons.This could mean that the complex formed between the catalyst and the anion to react is stabilized for certain carbon lengths by inner solvation in virtue of its spatial conformation.