1240948-72-4

Basic information

• Product Name: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
• Synonyms: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile;1H-Pyrrole-3-carbonitrile,2-chloro-5-(2-fluorophenyl)-;Vonoprazan Fumarate impurity G;Vonoprazan Impurity 33;Vonoprazan Impurity Ⅶ
• CAS NO: 1240948-72-4
• Molecular Formula: C₁₁H₆ClFN₂
• Molecular Weight: 220.6301432
• EINECS: -0
• Mol File: 1240948-72-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 403.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.88±0.50(Predicted)
• CAS DataBase Reference: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile(1240948-72-4)
• EPA Substance Registry System: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile(1240948-72-4)

Safety Data

• Hazardous Substances Data: 1240948-72-4(Hazardous Substances Data)

Usage

Uses

2-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (Vonoprazan Impurity 33) is an impurity of Vonoprazan, a potassium-competitive acid blocker (P-CAB) that suppresses gastric acid secretion.

Upstream product

• 655-15-2 2-bromo-2'-fluoroacetophenone 
• 445-27-2 2'-Fluoroacetophenone 
• 312307-38-3 2-[2-(2-fluorophenyl)-2-oxoethyl]propanedinitrile 

Downstream Products

• 2098974-13-9 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methylmethylamine fumaric acid salt 
• 881677-11-8 5‐(2-fluorophenyl)‐1‐(pyridine-3-sulfonyl)-1H-pyrrole-3-carbaldehyde 
• 881674-56-2 5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde 
• 1240948-77-9 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 
• 881681-00-1 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-yl)-N-methylmethanamine 
• 1883595-39-8 C₁₇H₁₄FN₃O₃S 
• 1807642-39-2 5-(2-fluorophenyl)-1-(pyridin-3-yl-sulfonyl)-1H-pyrrole-3-carbonitrile 
• 1883595-37-6 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carboxylic acid 

Relevant articles and documents

Identification, characterization, synthesis of major metabolites biotransformed from vonoprazan fumarate

A first synthetic research concerning four observed metabolites and their deuterium-labeled analogues of reflux esophagitis drug vonoprazan fumarate is reported. Among which the synthetic methods of three metabolites M ? I, M-III, M-IV-Sul, and four stable isotop labeled analogues M-I-d4, M-II-d4, M-III-d4, M-IV-Sul-d4 have not yet been reported before. The structures of these compounds were elucidated on the basis of MS and NMR spectroscopy.

Substituted pyrrole-4-alkylamine compounds and application thereof

The invention relates to substituted pyrrole-4-alkylamine compounds and application thereof. The invention particularly provides application of compounds shown in a formula I, or optical isomers thereof, or racemates thereof, or solvates thereof, or pharm

A fumaric acid fertile norah approves key intermediate and its preparation method (by machine translation)

The present invention provides a kind of fumaric acid fertile norah approves key intermediate and its preparation method. The invention fumaric acid fertile norah approves a key intermediate in the preparation method mainly comprises 3 step process, the p