1240948-72-4

Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is used as an impurity in Vonoprazan, a P-CAB medication for the treatment of gastric acid-related disorders. Its presence in Vonoprazan is monitored and controlled to ensure the safety and efficacy of the drug.

Upstream product

• 312307-38-3 2-[2-(2-fluorophenyl)-2-oxoethyl]propanedinitrile 
• 445-27-2 2'-Fluoroacetophenone 
• 655-15-2 2-bromo-2'-fluoroacetophenone 

Downstream Products

• 2098974-13-9 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methylmethylamine fumaric acid salt 
• 881677-11-8 5‐(2-fluorophenyl)‐1‐(pyridine-3-sulfonyl)-1H-pyrrole-3-carbaldehyde 
• 881674-56-2 5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde 
• 1240948-77-9 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 
• 881681-00-1 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-yl)-N-methylmethanamine 
• 1883595-39-8 C₁₇H₁₄FN₃O₃S 
• 1807642-39-2 5-(2-fluorophenyl)-1-(pyridin-3-yl-sulfonyl)-1H-pyrrole-3-carbonitrile 
• 1883595-37-6 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carboxylic acid 

Relevant academic research and scientific papers

Identification, characterization, synthesis of major metabolites biotransformed from vonoprazan fumarate

A first synthetic research concerning four observed metabolites and their deuterium-labeled analogues of reflux esophagitis drug vonoprazan fumarate is reported. Among which the synthetic methods of three metabolites M ? I, M-III, M-IV-Sul, and four stable isotop labeled analogues M-I-d4, M-II-d4, M-III-d4, M-IV-Sul-d4 have not yet been reported before. The structures of these compounds were elucidated on the basis of MS and NMR spectroscopy.

Synthesis method of 5-(2-fluorophenyl)-1H-pyrrole-3-formaldehyde

The invention discloses a synthetic method of 5-(2-fluorophenyl)-1H-pyrrole-3-formaldehyde, and belongs to the field of organic synthesis. The preparation method comprises the following steps: (1) reacting 2-fluoro acetophenone with a bromination reagent

Substituted pyrrole-4-alkylamine compounds and application thereof

The invention relates to substituted pyrrole-4-alkylamine compounds and application thereof. The invention particularly provides application of compounds shown in a formula I, or optical isomers thereof, or racemates thereof, or solvates thereof, or pharm

Preparation method of pyrrole compound

The invention provides a preparation method of a pyrrole compound and belongs to the technical field of pharmacy. The preparation method comprises that a raw material compound and a halogenation reagent undergo a reaction in an organic solvent to produce

Novel pyrroles derivative as well as preparation method and pharmaceutical application thereof

The invention relates to a novel pyrroles derivative as well as a preparation method and pharmaceutical application thereof. Specifically, the invention relates to the novel pyrroles derivative shown as a general formula (I) as well as pharmaceutically ac

A fumaric acid fertile norah approves key intermediate and its preparation method (by machine translation)

The present invention provides a kind of fumaric acid fertile norah approves key intermediate and its preparation method. The invention fumaric acid fertile norah approves a key intermediate in the preparation method mainly comprises 3 step process, the p

PROCESS FOR PRODUCING PYRROLE COMPOUND

The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of produci