125-13-3

Usage

Uses

Used in Pharmaceutical Industry:
3,3-BIS(P-HYDROXYPHENYL)OXINDOLE is used as a prodrug for Oxyphenisatine, a diphenolic laxative. It has been found to inhibit the growth of breast cancer cell lines such as MCF7, T47D, HS578T, and MDA-MB-468. 3,3-BIS(P-HYDROXYPHENYL)OXINDOLE induces a multifaceted cell starvation response, which ultimately leads to programmed cell death. This makes it a promising candidate for the development of new cancer therapies.
Used in Cancer Research:
In cancer research, 3,3-BIS(P-HYDROXYPHENYL)OXINDOLE is used as a tool to study the mechanisms of cell starvation and programmed cell death. Understanding these processes can help researchers develop more effective treatments for various types of cancer.
Used in Drug Development:
3,3-BIS(P-HYDROXYPHENYL)OXINDOLE is used in the development of new drugs targeting cancer cells. Its ability to induce cell starvation and programmed cell death makes it a valuable compound for designing novel therapeutic agents that can potentially improve the treatment of various cancers.

InChI:InChI=1/C20H15NO3/c22-15-9-5-13(6-10-15)20(14-7-11-16(23)12-8-14)17-3-1-2-4-18(17)21-19(20)24/h1-12,22-23H,(H,21,24)

Upstream product

• 39033-45-9 3,3-dichloro-2,3-dihydro-1H-indol-2-one 
• 108-95-2 phenol 
• 91-56-5 indole-2,3-dione 
• 122-79-2 Phenyl acetate 

Downstream Products

• 93656-74-7 2,4-Bis-(4-nitro-phenylazo)-phenol 
• 115-33-3 Bisatin 
• 500028-15-9 3,3-bis(4-methoxyphenyl)indolin-2-one 
• 860563-29-7 2-amino-4'-hydroxy-benzophenone 
• 118-92-3 anthranilic acid 
• 1435-60-5 4-(4'-hydroxyphenylazo)nitrobenzene 
• 56632-45-2 sodium salt of 3-(4-hydroxyphenyl)-3-(4-sulphoxyphenyl)-2-indolinone 

Relevant academic research and scientific papers

Lambert Salt-Initiated Development of Friedel–Crafts Reaction on Isatin to Access Distinct Derivatives of Oxindoles

Herein, a mild metal-free and efficacious route for the synthesis of biologically important 3-aryl oxindole derivatives is described. Using Lambert salt-initiated hydroarylation of isatin, a diverse array of monoarylated products, symmetrical/unsymmetrical double-arylated products, and deoxygenated hydroarylated products could be synthesized from the single starting substrate in good to excellent yields. A preliminary mechanistic study revealed that the reaction proceeds via a monoarylated product followed by a nucleophilic attack by another electron-rich arene nucleophile under mild conditions. The potential of newly synthesized symmetric/unsymmetric 3,3-disubstituted oxindole, 3-substituted 3-hydroxy oxindoles, 3,3-di(indolyl)indolin-2-ones, and α-aryl oxindoles as valuable building blocks is further illustrated.

3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION

Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.

Friedel-Crafts type reactions of some activated cyclic ketones with phenol derivatives

Friedel-Crafts type reactions of phenol derivatives with some cyclic ketones such as ninhydrin (1), alloxan (2), isatin (3), and parabanic acid (4) were examined. 2-Monoaryl- and 2,2-diaryl-1,3-indanedione derivatives were obtained depending on the acid catalyst in the cases of ninhydrin and alloxan. In the case of isatin, the corresponding diarylated derivative was obtained as the sole product in high yields. Parabanic acid was unreactive under the reaction conditions.