137038-63-2Relevant academic research and scientific papers
A formal stereoselective synthesis of a hydroxyethylene dipeptide isostere
Peyrat, Jean-Francois
, p. 2757 - 2760 (2007/10/02)
4-Hydroxy-5-amino-6-phenyl-4-hexanolide has been synthesized under its cyclized form (lactone 5) from a very inexpensive chiral starting material, L-glutamic acid. The key steps were an original reduction of carbonyl of a ketone with n-Bu3SnH i
Studies of HIV-1 protease inhibitors. II. Incorporation of four types of hydroxyethylene dipeptide isosteres at the scissile site of substrate sequences
Sakurai,Higashida,Sugano,Nishi,Saito,Ohata,Handa,Komai,Yagi,Nishigaki,Yabe
, p. 1378 - 1386 (2007/10/02)
Human immunodeficiency virus type 1 (HIV-1) protease inhibitors containing four types of hydroxyethylene dipeptide isosteres were designed and synthesized. These inhibitors consist of eight stereoisomers of phenylalanylproline (Phe-Ψ[H.E.]-Pro), four ster
An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors
Ghosh, Arun K.,McKee, Sean P.,Thompson, Wayne J.
, p. 6500 - 6503 (2007/10/02)
An efficient and stereocontrolled synthesis of hydroxyethylene dipeptide isosteres 1 from commercially available, optically pure D-mannose is described.This synthesis represents a practical and enantioselective entry to a range of other dipeptide isostere
