1254966-66-9

Basic information

• Product Name: 2-Oxa-6-azaspiro[3.3]heptane xoxalate
• Synonyms: 2-Oxa-6-azaspiro[3.3]heptane xoxalate
• CAS NO: 1254966-66-9
• Molecular Formula: C7H11NO5
• Molecular Weight: 189.16594
• Mol File: 1254966-66-9.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Oxa-6-azaspiro[3.3]heptane xoxalate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxa-6-azaspiro[3.3]heptane xoxalate(1254966-66-9)
• EPA Substance Registry System: 2-Oxa-6-azaspiro[3.3]heptane xoxalate(1254966-66-9)

Safety Data

• Hazardous Substances Data: 1254966-66-9(Hazardous Substances Data)

Upstream product

• 2402-83-7 3,3-bis(bromomethyl)oxetane 
• 78-71-7 3,3-bis(chloromethyl)oxetane 
• 1522-92-5 2,2-bis(bromomethyl)-3-bromo-propan-1-ol 
• 144-62-7 oxalic acid 
• 46246-91-7 2-benzyl-6-oxa-2-azaspiro[3.3]-heptane 
• 13573-28-9 6-(p-toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane 
• 174-78-7 2-oxa-6-azaspiro[3.3]heptane 

Downstream Products

• 1449279-91-7 N-((1S,2R)-2-hydroxy-3-oxo-1-phenyl-3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)propyl)-benzamide 
• 1449279-92-8 tert-butyl (1S,2R)-2-hydroxy-3-oxo-1-phenyl-3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-propylcarbamate 
• 1449279-89-3 (4S,5R)-(3-benzoyl-2-(4-methoxyphenyl)-4-phenyloxazolidin-5-yl)(2-oxa-6-azaspiro[3.3]heptan-6-yl)methanone 
• 1449279-90-6 (4S,5R)-tert-butyl-2-(4-methoxyphenyl)-4-phenyl-5-(2-oxa-6-azaspiro[3.3]heptane-6-carbonyl)oxazolidine-3-carboxylate 
• 1449710-19-3 5-{2-[3-methoxy-4-(2-oxa-6-azaspiro[3.3]heptane-6-carbonyl)phenyl]furo[3,2-b]pyridin-7-yl}-2-(tetrahydropyran-4-yloxy)benzonitrile 
• 1370444-27-1 2-[3-(3-chlorophenyl)-1-{4-[2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]phenyl}-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide 
• 1240402-44-1 {3-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-isoxazol-5-yl}-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-methanone 
• 1426257-54-6 2-[(S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethan-1-one 
• 1431648-15-5 N-(6-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridin-2-yl)-6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-3-carboxamide 

Relevant articles and documents

Synthesis and Properties of 2-Oxa-6-azaspiro[3.3]heptane Sulfonate Salts

An improved synthesis of the bicyclic spiro compound 2-oxa-6-azaspiro[3.3]heptane is presented. While this compound is often isolated as an oxalate salt, its isolation as a sulfonic acid salt yields a more stable and more soluble product. With these improved properties access to a wider range of reaction conditions with the spirobicyclic 2-oxa-6-azaspiro[3.3]heptane has been enabled.

Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents

The design, synthesis and antimicrobial evaluation of a novel series of azaspiro analogues of linezolid (1) have been described. Linezolid comprises of a morpholine ring which is known for its metabolism-related liabilities. Therefore, the key modificatio

Design, synthesis and biological evaluation of paclitaxel-mimics possessing only the oxetane D-ring and side chain structures

Two spiro paclitaxel-mimics consisting only of an oxetane D-ring and a C-13 side chain were designed and synthesized on the basis of analysis of structure-activity relationships (SAR) of paclitaxel. In vitro microtubule-stabilizing and antiproliferative assays indicated a moderate weaker activity of the mimics than paclitaxel, but which still represented the first example of simplified paclitaxel analogues with significant anti-tumor biological activity.