125787-65-7Relevant academic research and scientific papers
BICHEP-Ru complexes, highly efficient catalysts for asymmetric hydrogenation of carbonyl compounds
Chiba,Miyashita,Nohira,Takaya
, p. 2351 - 2354 (1993)
Newly prepared [RuX(p-cymene)(bichep)]X (X = I, Cl) and Ru(OAc)2(bichep) (bichep = 2,2'-bis(dicyclohexylphosphino)-6,6'-dimethyl-1,1'-biphenyl) proved to be highly efficient catalysts for asymmetric hydrogenation of carbonyl compounds bearing phenylglyoxyloyl group under mild conditions.
5-endo-dig Cyclization of O-Propargyl Mandelic Acid Amides towards 2,5-Dihydrofurans
Gaied, Lilia Ben,Fincias, Nicolas,Garrec, Julian,Ka?m, Laurent El
, p. 7656 - 7665 (2019/12/24)
5-endo-dig cyclization of O-propargyloxyamides, obtained through a Passerini reaction mediated by boric acid and subsequent propargylation, affords 2,5-dihydrofurans in the presence of tert-butylate. The mechanism of the reaction was studied by using DFT calculations and the results were compared with the behavior of analogous N-propargylamide derivatives.
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides
Serafini, Marta,Griglio, Alessia,Oberto, Elena,Pirali, Tracey,Tron, Gian Cesare
supporting information, p. 4786 - 4789 (2017/11/29)
Dozens of strategies have been described for the synthesis of α-hydroxyamides over the years, but they share common drawbacks in terms of generality and tolerability, especially to acid labile functionalities. Here we report a truncated Passerini reaction suitable for the easy and mild preparation of functionalized α-hydroxyamides. In particular, this procedure is tolerant to acid sensitive protecting groups, which remain intact during the multicomponent reaction.
Preparation method of mandelamine compound
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, (2017/07/22)
The invention discloses a preparation method of a mandelamine compound. The preparation method is a complete synthesis method for finally synthesizing a compound with a mandelamine parent by using a benzaldehyde compound as an initiator. An amido bond synthesis part adopts a polarity reversal reaction mechanism of using an amino segment to perform electrophilic attack on an acyl segment. The preparation method can be used for synthesizing multiple compounds which cannot be synthesized by the traditional method.
Chemoselective Reductive Deoxygenation and Reduction of α-Keto Amides by using a Palladium Catalyst
Mamillapalli, N. Chary,Sekar, Govindasamy
, p. 3273 - 3283 (2015/11/03)
A palladium catalyst is used to synthesize 2,N-diphenylacetamides and α-hydroxy amides from readily available α-keto amides by chemoselective reductive deoxygenation and chemoselective reduction using polymethylhydrosiloxane (PMHS). This methodology has t
Metal free chemoselective reduction of α-keto amides using TBAF as catalyst
Mamillapalli, N. Chary,Sekar, Govindasamy
, p. 61077 - 61085 (2015/02/19)
The metal and ligand free chemoselective reduction of the keto group and complete reduction of the both keto and amide groups of α-keto amide with hydrosilanes using tetrabutylammoniumflouride (TBAF) as catalyst have been accomplished. This methodology affords an efficient and economic route for the synthesis of biologically important α-hydroxy amides and β-amino alcohols. The other important advantage of this TBAF catalyst is chemoselective reduction of ketones to corresponding alcohols in the presence of several other sensitive functional groups.
Chemoselective reduction of α-keto amides using nickel catalysts
Mamillapalli, N. Chary,Sekar, Govidasamy
supporting information, p. 7881 - 7884 (2014/07/08)
Ni-catalysts are used for the first time to synthesize highly important α-hydroxy amides and β-amino alcohols from α-keto amides by chemoselective and complete reduction using hydrosilanes. Chemoselective complete reduction of α-keto amides in the presenc
One-pot synthesis of α-hydroxyamides using alkyl isocyanides and aryl aldehydes
Bayat, Mohammad,Nasri, Shima,Hosseini, Hajar,Hassanzadeh, Fateme
experimental part, p. 801 - 804 (2012/08/07)
A simple and efficient approach for the synthesis of α-hydroxyamides in fairly good yields by the reaction of aromatic aldehydes and alkyl isocyanides at room temperature is presented. Springer-Verlag 2011.
Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture
Steuer, Christian,Gege, Christian,Fischl, Wolfgang,Heinonen, Karl H.,Bartenschlager, Ralf,Klein, Christian D.
supporting information; experimental part, p. 4067 - 4074 (2011/08/21)
The development of small molecule inhibitors of the viral protease is of considerable interest for the treatment of emergent flaviviral diseases such as Dengue or West Nile fever. Until today little progress has been made in finding drug-like compounds th
An efficient boric acid-mediated preparation of α-hydroxyamides
Sravan Kumar,Jonnalagadda, Subash C.,Mereddy, Venkatram R.
experimental part, p. 779 - 782 (2010/03/24)
An efficient methodology for the preparation of α-hydroxyamides via boric acid-mediated addition of isonitriles onto aldehydes has been developed. The reaction of isonitriles with α-boronobenzaldehyde takes place under intramolecular catalysis conditions
