126775-22-2

Upstream product

• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 51008-81-2 N⁶,N⁶-dibenzoyladenosine 
• 98-88-4 benzoyl chloride 
• 58-61-7 adenosine 

Downstream Products

• 126775-28-8 N-[9-(3-allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-N-benzoyl-benzamide 
• 649719-87-9 N-{9-[3-(tert-butyl-dimethyl-silanyloxymethyl)-6-methyl-5,8-dioxo-1,3,3a,6,7,8,9,10,13,14a-decahydro-5H-2,4,14-trioxa-7-aza-cyclopentacyclotridecen-1-yl]-9H-purin-6-yl}-benzamide 
• 649719-86-8 (S)-2-Pent-4-enoylamino-propionic acid (2R,3R,4R,5R)-4-allyloxy-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester 
• 1306597-64-7 N6,N6-dibenzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzyl-α-D-ribofuranosyl)-β-D-ribofuranosyl]adenine 
• 1392269-72-5 C₅₃H₆₅N₇O₇Si₂ 
• 1392269-71-4 C₄₉H₅₇N₇O₇Si₂ 
• 1392269-79-2 C₃₅H₄₈N₇O₇P 
• 1392269-84-9 C₂₃H₂₆N₇O₁₃P₃ 
• 1392269-85-0 C₂₇H₃₄N₇O₁₃P₃ 

Relevant academic research and scientific papers

Synthesis of 2'-O,3'-O bicyclic adenosine analogues using ring closing metathesis

The synthesis of 2'-O,3'-O bicyclic adenosine derivatives is presented as the first examples of a new family of 13-membered ring bicyclic nucleoside analogues. Cyclisation was achieved through ring closing metathesis (RCM) on a diene intermediate using Grubbs' catalyst. The Z and E isomers were purified and characterised.

A photochromic ATP analogue driving a motor protein with reversible light-controlled motility: Controlling velocity and binding manner of a kinesin-microtubule system in an in vitro motility assay

We synthesized two photochromic ATP analogues (ATP-Azos) featuring azobenzene derivatives tethered at the 2′ position of the ribose ring. In the presence of the ATP-Azo tethering p-tert-butylazobenzene, we observed reversible photo-control of the motility, velocity and binding manner, of a kinesin-microtubule system in an in vitro motility assay.

Preparation of zwitterionic ribonucleoside phosphoramidites for solid-phase siRNA synthesis

(Chemical Equation Presented) RNA oligomers, carrying 2′-O-modified nucleosides, proved to be extremely useful in different antisense strategies, including RNAi. The 2′-O-alkyl modification, carrying an amino functionality, deserves special attention due

Different strategies for the synthesis of 2′-O-aminoethyl adenosine building blocks

The chemical modification of the 2′-O-position of nucleosides proved to be of great importance for the RNA stability. Greater stability of RNA duplexes allows a longer half life in the cell and, therefore, a better effect of RNA Interference. Here we inve