51008-81-2

Basic information

• Product Name: Adenosine, N,N-dibenzoyl-
• CAS NO: 51008-81-2
• Molecular Formula: C24H21N5O6
• Molecular Weight: 475.461
• Mol File: 51008-81-2.mol

Chemical Properties

• CAS DataBase Reference: Adenosine, N,N-dibenzoyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Adenosine, N,N-dibenzoyl-(51008-81-2)
• EPA Substance Registry System: Adenosine, N,N-dibenzoyl-(51008-81-2)

Safety Data

• Hazardous Substances Data: 51008-81-2(Hazardous Substances Data)

Upstream product

• 610305-23-2 O^2;_,O3'_,O5'-tris-trimethylsilyl-N⁶,N⁶-dibenzoyladenosine 
• 58-61-7 adenosine 
• 10457-15-5 O^2'_,O3'_,O5'-tris-trimethylsilanyl-adenosine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 126775-22-2 N6-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]adenine 
• 126775-28-8 N-[9-(3-allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-N-benzoyl-benzamide 
• 649719-86-8 (S)-2-Pent-4-enoylamino-propionic acid (2R,3R,4R,5R)-4-allyloxy-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester 
• 649719-82-4 N-{9-[3-allyloxy-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-N-benzoyl-benzamide 
• 649719-89-1 N-[9-(3-allyloxy-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-N-benzoyl-benzamide 
• 649719-83-5 N-{9-[3-allyloxy-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 4546-55-8 N-benzoyladenosine 

Relevant articles and documents

A photochromic ATP analogue driving a motor protein with reversible light-controlled motility: Controlling velocity and binding manner of a kinesin-microtubule system in an in vitro motility assay

We synthesized two photochromic ATP analogues (ATP-Azos) featuring azobenzene derivatives tethered at the 2′ position of the ribose ring. In the presence of the ATP-Azo tethering p-tert-butylazobenzene, we observed reversible photo-control of the motility, velocity and binding manner, of a kinesin-microtubule system in an in vitro motility assay.

An improved transient method for the synthesis of N-benzoylated nucleosides

The Jones' transient method for the synthesis of N-benzoylated nucleosides is improved by reducing the amounts of chlorotrimethylsilane (TMSCl) and benzoyl chloride to nearly equivalent quantities. The easy work-up and high yields of products are the major advantages of this approach. Jones' method is further simplified by omitting the addition of ammonium hydroxide. The utility of this modification for the preparation of some useful protected nucleosides is also presented.

Synthesis of 2'-O,3'-O bicyclic adenosine analogues using ring closing metathesis

The synthesis of 2'-O,3'-O bicyclic adenosine derivatives is presented as the first examples of a new family of 13-membered ring bicyclic nucleoside analogues. Cyclisation was achieved through ring closing metathesis (RCM) on a diene intermediate using Grubbs' catalyst. The Z and E isomers were purified and characterised.