649719-86-8

Upstream product

• 126775-28-8 N-[9-(3-allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-N-benzoyl-benzamide 
• 126775-22-2 N6-benzoyl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]adenine 
• 649719-82-4 N-{9-[3-allyloxy-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-N-benzoyl-benzamide 
• 649719-89-1 N-[9-(3-allyloxy-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-N-benzoyl-benzamide 
• 51008-81-2 N⁶,N⁶-dibenzoyladenosine 
• 58-61-7 adenosine 
• 98-88-4 benzoyl chloride 
• 649719-84-6 (S)-2-Pent-4-enoylamino-propionic acid 
• 649719-83-5 N-{9-[3-allyloxy-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 

Downstream Products

• 649719-87-9 N-{9-[3-(tert-butyl-dimethyl-silanyloxymethyl)-6-methyl-5,8-dioxo-1,3,3a,6,7,8,9,10,13,14a-decahydro-5H-2,4,14-trioxa-7-aza-cyclopentacyclotridecen-1-yl]-9H-purin-6-yl}-benzamide 

Relevant academic research and scientific papers

Synthesis of 2'-O,3'-O bicyclic adenosine analogues using ring closing metathesis

The synthesis of 2'-O,3'-O bicyclic adenosine derivatives is presented as the first examples of a new family of 13-membered ring bicyclic nucleoside analogues. Cyclisation was achieved through ring closing metathesis (RCM) on a diene intermediate using Grubbs' catalyst. The Z and E isomers were purified and characterised.