649719-86-8Relevant articles and documents
Synthesis of 2'-O,3'-O bicyclic adenosine analogues using ring closing metathesis
Busca, Patricia,Etheve-Quelquejeu, Melanie,Valery, Jean-Marc
, p. 9131 - 9134 (2007/10/03)
The synthesis of 2'-O,3'-O bicyclic adenosine derivatives is presented as the first examples of a new family of 13-membered ring bicyclic nucleoside analogues. Cyclisation was achieved through ring closing metathesis (RCM) on a diene intermediate using Grubbs' catalyst. The Z and E isomers were purified and characterised.