126872-16-0

Upstream product

• 524-69-6 adenine xyloside 
• 42927-46-8 tetra-O-acetyl-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 20881-04-3 1,2:3,5-di-O-isopropylidene-D-xylofuranose 
• 1824-96-0 methyl α-D-xylofuranoside 
• 2280-44-6 D-Glucose 
• 141923-44-6 α-Ara(f)-(1->3)-β-Xyl(p)-(1->4)-Xyl(p) 
• 128730-82-5 3-O-β-D-glucopyranosyl(1->3)-α-L-rhamnopyranosyl(1->2)-α-L-arabinopyranosyl-hederagenin 
• 108646-19-1 3-Carbamoyl-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-pyridinium 
• 572-30-5 3,3',4',5,7-pentahydroxyflavone 3-O-arabogluocopyranoside 
• 3228-71-5 9-(α-D-arabinofuranosyl)adenine 
• 61826-42-4 tetra-O-acetyl-D-arabinofuranose 
• 68768-32-1 3-methylguanosine 
• 30802-00-7 hydroxycinnamoyl-S-CoA 

Downstream Products

• 100604-20-4 (3aS,5R,6S,6aR)-2-<2,3,3a,5,6,6a-Hexahydro-6-hydroxy-5-(hydroxymethyl)furo<2,3-d>oxazol-2-yliden>cyanessigsaeure-methylester 
• 1824-97-1 methyl β-D-xylofuranoside 
• 1824-96-0 methyl xylofuranoside 
• 98-01-1 furfural 
• 64-18-6 formic acid 
• 79-14-1 glycolic Acid 
• 849585-22-4 LACTIC ACID 
• 64-19-7 acetic acid 
• 127-17-3 2-oxo-propionic acid 
• 51754-99-5 Methyl 3,5-O-Isopropylidene-β-D-xylofuranoside 
• 7045-40-1 Methyl 3,5-O-Isopropylidene-α-D-xylofuranoside 
• 15384-37-9 D-xylono-1,4-lactone 
• 6022-96-4 5-O-benzoyl-α-D-xylofuranose 
• 142329-54-2 (2R,3R,4R,5R)-2-Allyloxy-5-hydroxymethyl-tetrahydro-furan-3,4-diol 

Relevant academic research and scientific papers

New terpenoids from Stachys parviflora Benth

Two new triterpenoidal saponins were isolated from the n-butanolic extract of Stachys parviflora (Lamiaceae). Their structures were elucidated on the basis of spectral data as stachyssaponin A; 3β, 15α, 19α, 21β, 22α-pentahydroxyolean-12-ene-28-oic acid 3-O-{α-L-rhamnopyranosyl-(1 → 3)-β-D-glucopyranoside)-22-O-{α-L-arabinofuranosyl-(1 → 3)-β-D-glucopyranoside) (1) and stachyssaponin B; 2β, 3β, 15α, 21β-tetrahydroxyolean-12-ene-28-oic acid 2-O-[a-L- arabinofuranoside]-3, 21-bis-O-[β-D-glucopyranoside] (2). Copyright

Lebbeckoside C, a new triterpenoid saponin from the stem barks of Albizia lebbeck inhibits the growth of human glioblastoma cells

One new acacic acid-type saponin, named lebbeckoside C (1), was isolated from the stem barks of Albizia lebbeck. Its structure was established on the basis of extensive analysis of 1D and 2D NMR (1H, 13C NMR, DEPT, COSY, TOCSY, ROESY, HSQC and HMBC) experiments, HRESIMS studies, and by chemical evidence as 3-O-[β-d-xylopyranosyl-(l→2)-β-d-fucopyranosyl-(1→6)-[β-d-glucopyranosyl(1→2)]-β-d-glucopyranosyl]-21-O-{(2E,6S)-6-O-{4-O-[(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl)octa-2,7-dienoyl]-4-O-[(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl)octa-2,7-dienoyl]-β-d-quinovopyranosyl}-2,6-dimethylocta-2,7-dienoyl}acacic acid 28 O-[β-d-quinovopyranosyl-(l→3)-[α-l-arabinofuranosyl-(l→4)]-α-l-rhamnopyranosyl-(l→2)-β-d-glucopyranosyl] ester. The isolated saponin (1) displayed significant cytotoxic activity against the human glioblastoma cell line U-87 MG and TG1 stem-like glioma cells isolated from a patient tumor with IC50 values of 1.69 and 1.44?μM, respectively.

Structural and biochemical characterization of the nucleoside hydrolase from C. elegans reveals the role of two active site cysteine residues in catalysis

Nucleoside hydrolases (NHs) catalyze the hydrolysis of the N-glycoside bond in ribonucleosides and are found in all three domains of life. Although in parasitic protozoa a role in purine salvage has been well established, their precise function in bacteria and higher eukaryotes is still largely unknown. NHs have been classified into three homology groups based on the conservation of active site residues. While many structures are available of representatives of group I and II, structural information for group III NHs is lacking. Here, we report the first crystal structure of a purine-specific nucleoside hydrolase belonging to homology group III from the nematode Caenorhabditis elegans (CeNH) to 1.65? resolution. In contrast to dimeric purine-specific NHs from group II, CeNH is a homotetramer. A cysteine residue that characterizes group III NHs (Cys253) structurally aligns with the catalytic histidine and tryptophan residues of group I and group II enzymes, respectively. Moreover, a second cysteine (Cys42) points into the active site of CeNH. Substrate docking shows that both cysteine residues are appropriately positioned to interact with the purine ring. Site-directed mutagenesis and kinetic analysis proposes a catalytic role for both cysteines residues, with Cys253 playing the most prominent role in leaving group activation.

New Cytotoxic Triterpenoid Saponins from the Roots of Albizia gummifera (J.F.Gmel.) C.A.Sm.

As part of our search for new bioactive saponins from Cameroonian medicinal plants, two new oleanane-type saponins, named gummiferaosides D and E (1 and 2), along with one known saponin, julibroside J8 (3), were isolated from the roots of Albizia gummifera. Their structures were established on the basis of extensive 1D- and 2D-NMR (1H- and 13C-NMR, DEPT, COSY, TOCSY, NOESY, HSQC, HSQC-TOCSY, and HMBC) and HR-ESI-MS studies, and by chemical evidence. The apoptotic effect of saponins 1?–?3 was evaluated on the A431 human epidermoid cancer cell. Flow cytometric analyses showed that saponins 1?–?3 induced apoptosis of human epidermoid cancer cell (A431) in a dose-dependent manner.

New glycosidic constituents of abutilon Pakistanicum

Pakisides A and B (1 and 2, resp.), new catalpol-type iridoid glycosides, and a new glycoside, 3, of scutellarein have been isolated from the AcOEt-soluble fraction of the whole plant of Abutilon pakistanicum, along with buddlejoside and lapachol. The structures of new compounds were elucidated by spectroscopic techniques including 1H-and 13C-NMR (DEPT), and 2D-NMR experiments. Copyright 2010 Verlag Helvetica Chimica Acta AG, Zuerich, Switzerland.

Anti-allergic inflammatory components from Sanguisorba officinalis L.

Sanguisorba officinalis L. was well known as a traditional herbal medicine to treat inflammation and allergic skin diseases. The aim of this research was to indentify compounds with anti-allergic inflammatory property. Twenty-five compounds (1–25) were isolated from S. officinalis including two new compounds (1 and 8), and their chemical structures were identified by NMR and ESIMS analysis. Consequently, the anti-allergic inflammatory activities of these isolates were investigated by inhibiting β-hexosaminidase and IL-4 production in PMA/A23187-stimulated RBL-2H3 cells. Compounds 6, 8, 13, 17–18 and 25 significantly inhibited β-hexosaminidase release and IL-4 production. Additionally, compounds 8, 17 and 25 effectively suppressed the activation of NF-κB and NF-κB p65 translocation into the nucleus. Anti-inflammatory effects of isolated compounds were evaluated in LPS-stimulated RAW264.7 macrophages, and they showed dramatic inhibition on LPS-induced overproduction of nitric oxide (NO) and TNF-α. Consistently, the protein levels of iNOS and COX-2 were remarkably decreased by the single compounds 8, 13 and 25. These results showed that compounds 8, 13 and 25 from S. officinalis may have a therapeutic potential for allergic inflammatory diseases.

New benzophenone and quercetin galloyl glycosides from Psidium guajava L.

New benzophenone and flavonol galloyl glycosides were isolated from an 80% MeOH extract of Psidium guajava L. (Myrtaceae) together with five known quercetin glycosides. The structures of the novel glycosides were elucidated to be 2,4,6-trihydroxybenzophenone 4-O-(6′-O-galloyl)-β-D- glucopyranoside (1, guavinoside A), 2,4,6-trihydroxy-3,5-dimethylbenzophenone 4-O-(6′-Ogalloyl)-β-D-glucopyranoside (2, guavinoside B), and quercetin 3-O-(5′-O-galloyl)-a-L-arabinofuranoside (3, guavinoside C) by NMR, MS, UV, and IR spectroscopies. Isolated phenolic glycosides showed significant inhibitory activities against histamine release from rat peritoneal mast cells, and nitric oxide production from a murine macrophage- like cell line, RAW 264.7. The Author(s) 2010.

OBTUSILOBICININ, A NEW SAPONIN FROM ANEMONE OBTUSILOBA

Key Word Index -- Anemone obtusiloba; Ranunculaceae; obtusilobicinin; olean-12-ene-28-oic-3-O-(α-L-arabinofuranosyl 1->2) (α-L-arabinofuranosyl 1->2-O-α-L-rhamnopyranosyl 1->4)-β-D-glucopyranoside.

Biosynthesis of the thiamin pyrimidine: The reconstitution of a remarkable rearrangement reaction

The conversion of 5-aminoimidazole ribonucleotide (AIR) into 4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP) is a fascinating reaction on the thiamin biosynthetic pathway in bacteria and is probably the most complex unresolved rearrangement in primary metabolism. We have successfully reconstituted this reaction in a cell-free system. The E. coli thiC gene product and an additional unidentified E. coli protein are required for the reaction. In addition, SAM and nicotinamide cofactors are required for full activity. Labeling studies to determine the origin of most of the atoms in the pyrimidine are described. Based on these studies, a new mechanism for HMP formation is proposed.

A method for the rapid discovery of naturally occurring products by proteins immobilized on magnetic beads and reverse affinity chromatography

A highly efficient screening method for naturally occurring products that bind to a specific target protein was demonstrated by using hVDR magnetic beads. The native ligand 1α, 25(OH)2 VD3 (1) was selectively bound by hVDR magnetic b