126899-77-2

Upstream product

• 56072-16-3 1,2-diphenyl-pent-4-ene-1,2-diol 
• 947-91-1 Diphenylacetaldehyde 
• 107-18-6 allyl alcohol 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 762-72-1 allyl-trimethyl-silane 
• 26205-39-0 1,2-diphenyl-2-(trimethylsilyloxy)ethanone 
• 412335-94-5 2,2-diphenyl-4-pentene-1-ol 
• 107556-96-7 methyl 2,2-diphenyl-4-pentenoate 
• 3469-00-9 methyl 2,2-diphenylacetate 
• 55103-28-1 1-tert.-Butylamino-2,2-diphenylethylen 
• 13959-93-8 1,2-diphenyl-2-triethylsilyloxyethanone 
• 86-29-3 Diphenylacetonitrile 
• 7664-93-9 sulfuric acid 
• 194989-04-3 tert-butyl-(2,2-diphenyl-pent-4-enylidene)-amine 

Downstream Products

• 101594-41-6 2,2-diphenylpentanal 
• 126899-78-3 N-(2,2-Diphenyl-4-pentenylidene)methanamine N-oxide 
• 126899-79-4 1,5-dimethyl-3,3-diphenyl-2-pyrrolidinol 1-oxide 
• 220626-55-1 (2,3-Dibromo-propyl)-[2,2-diphenyl-pent-4-en-(E)-ylidene]-amine 
• 119-61-9 benzophenone 
• 65-85-0 benzoic acid 
• 53001-06-2 2,2-diphenyl-4-pentenylamine 
• 1015419-59-6 N-phenyl-2,2-diphenylpent-4-en-1-amine 
• 41921-30-6 3,3-diphenyl-5-hexen-2-ol 
• 1570094-74-4 (E)-ethyl 4,4-diphenylhepta-2,6-dienoate 
• 1570094-18-6 C₁₉H₂₀ 

Relevant academic research and scientific papers

Pd-catalyzed α-allylation of 2-phenylpropanal and other carbonyl compounds with allyl alcohol and allyl acetates/carbonates in ionic liquids

The successful Pd-catalysed allylation of 2-phenylpropanal with allyl alcohol in ionic liquid is described and thus a simplier reaction composition catalytic system than in THF is possible. On the other hand, the Pd-catalyzed α-allylation of the same substrate with allyl acetate or allyl ethyl carbonate is proceeding nicely in ionic liquids. Allylation of different carbonyl derivatives was studied and it was found that the reaction is restricted to carbonyl derivatives from which a carbanion stabilized by an adjacent aromatic ring can be formed.

Copper-catalyzed enantioselective alkene carboetherification for the synthesis of saturated six-membered cyclic ethers

The enantioselective copper-catalyzed oxidative coupling of alkenols with styrenes for the construction of dihydropyrans, isochromans, pyrans and morpholines is reported. A concise formal synthesis of a σ1receptor ligand using this alkene carbo

Catalyst- And Silane-Controlled Enantioselective Hydrofunctionalization of Alkenes by Cobalt-Catalyzed Hydrogen Atom Transfer and Radical-Polar Crossover

The catalytic enantioselective synthesis of tetrahydrofurans, which are found in the structures of many biologically active natural products, via a transition-metal-catalyzed hydrogen atom transfer (TM-HAT) and radical-polar crossover (RPC) mechanism is described herein. Hydroalkoxylation of nonconjugated alkenes proceeded efficiently with excellent enantioselectivity (up to 94% ee) using a suitable chiral cobalt catalyst, N-fluoro-2,4,6-collidinium tetrafluoroborate, and diethylsilane. Surprisingly, the absolute configuration of the product was highly dependent on the steric hindrance of the silane. Slow addition of the silane, the dioxygen effect on the solvent, thermal dependence, and DFT calculation results supported the unprecedented scenario of two competing selective mechanisms. For the less-hindered diethylsilane, a high concentration of diffused carbon-centered radicals invoked diastereoenrichment of an alkylcobalt(III) intermediate by a radical chain reaction, which eventually determined the absolute configuration of the product. On the other hand, a more hindered silane resulted in less opportunity for a radical chain reaction, instead facilitating enantioselective kinetic resolution during the late-stage nucleophilic displacement of the alkylcobalt(IV) intermediate.

Nickel-Catalyzed α-Allylation of Aldehydes and Tandem Aldol Condensation/Allylation Reaction with Allylic Alcohols

An additive-free nickel-catalyzed α-allylation of aldehydes with allyl alcohol is reported. The reaction is promoted by 1 mol % of in situ formed nickel complex in methanol, and water is the sole by-product of the reaction. The experimental conditions allow the conversion of various α-branched aldehydes and α,β-unsaturated aldehydes as nucleophiles. The same catalyst and reaction conditions enabled a tandem aldol condensation of aldehyde/α-allylation reaction.

Isomerization of olefins triggered by rhodium-catalyzed C-H bond activation: Control of endocyclic β-hydrogen elimination

Five-membered metallacycles are typically reluctant to undergo endocyclic β-hydrogen elimination. The rhodium-catalyzed isomerization of 4-pentenals into 3-pentenals occurs through this elementary step and cleavage of two C-H bonds, as supported by deuterium-labeling studies. The reaction proceeds without decarbonylation, leads to trans olefins exclusively, and tolerates other olefins normally prone to isomerization. Endocyclic β-hydrogen elimination can also be controlled in an enantiodivergent reaction on a racemic mixture.

Copper(I)-catalyzed intramolecular hydroalkoxylation of unactivated alkenes

A Cu(I)-Xantphos system catalyzed the intramolecular hydroalkoxylation of unactivated terminal alkenes, giving five- and six-membered ring ethers. This system is applicable to both primary and secondary alcohols. A reaction pathway involving the addition of the Cu-O bond across the C-C double bond is proposed. A chiral Cu(I) catalyst system based on the (R)-DTBM-SEGPHOS ligand promoted enantioselective reaction with moderate enantioselectivity.

Multicatalytic synthesis of complex tetrahydrofurans involving bismuth(iii) triflate catalyzed intramolecular hydroalkoxylation of unactivated olefins

A multicatalytic synthesis of complex tetrahydrofurans has been developed involving a Bi(OTf)3-catalyzed nucleophilic addition/ hydroalkoxylation sequence. Complex tetrahydrofuranyl products may be formed rapidly in high yield and with good diastereoselectivity. The demonstrated scope of hydroalkoxylation has also been expanded to include substrates bearing useful functional handles including carboxylate ester, olefin, nitrile, and nitro groups.

Platinum-catalyzed intramolecular hydroamination of unactivated olefins with secondary alkylamines

Reaction of benzyl-2,2-diphenyl-4-pentenylamine with a catalytic 1:2 mixture of [PtCl2(H2C=CH2)]2 (2.5 mol %) and PPh3 in dioxane at 120 °C for 16 h led to isolation of 1-benzyl-2-methyl-4,4-diphenylp

Remarkable enhancement of Lewis acidity of chlorosilane by the combined use of indium(III) chloride

A combination of InCl3 and R3SiCl provided a strong Lewis acid catalyst for such reactions as allylation, hydrosilation and Friedel-Crafts alkylation. Especially, catalytic Sakurai-Hosomi-type allylation was accomplished with high yield and selectivity. The silicon atom is assumed to be the acidic center of the combined system, and the catalytic activity largely depends on the substituents on the silicon center.

Synthesis of pyrrolizidines by cascade reactions of N- alkenylaziridinylmethyl radicals

Pyrrolizidines were synthesized in a one-step-reaction from 2- (bromomethyl)aziridines via a cascade of radical reactions involving aziridinylmethyl radicals. N-allylaminyl radicals and carbon-centered pyrrolidinyl radicals.