56072-16-3Relevant academic research and scientific papers
Ready Access to Densely Substituted Furans Using Tsuji-Wacker-Type Cyclization
Masal, Dattatraya P.,Choudhury, Rahul,Singh, Aman,Reddy, D. Srinivasa
, p. 556 - 568 (2022/01/14)
A competent method for the construction of highly substituted furans catalyzed by Pd(II) and Cu(II) chloride has been developed. The method provides easy access to di-, tri-, and tetrasubstituted furans from corresponding diols with relatively mild condit
Indirect Tertiary Alcohol Enantiocontrol by Acylative Organocatalytic Kinetic Resolution
Amalian, Jean-Arthur,Bressy, Cyril,Charles, Laurence,Desrues, Titouan,Liu, Xueyang,Monnier, Valérie,Pons, Jean-Marc,Quintard, Adrien
supporting information, p. 4332 - 4336 (2021/06/27)
The stereocontrol of tertiary alcohols represents a recurrent challenge in organic synthesis. In the present paper, we describe a simple, efficient, and indirect method to enantioselectively prepare tertiary alcohols through a chiral isothiourea catalyzed
Zinc-Mediated Efficient and Selective Reduction of Carbonyl Compounds
Mandal, Tirtha,Jana, Snehasish,Dash, Jyotirmayee
, p. 4972 - 4983 (2017/09/13)
We herein describe for the first time that an optimized combination of Zn and NH4Cl can be used for the selective reduction of aldehydes and ketones to the corresponding alcohols. The aldehyde and keto groups are selectively reduced in the presence of azide, cyano, epoxy, ester, and carbon–carbon double-bond functional groups. A broad functional-group compatibility, chemoselective reduction of aldehydes in the presence of ketones, and selective reduction of isatins at the C3 carbonyl group are the highlights of the present method.
2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents
Singh, Palwinder,Mittal, Anu,Kaur, Satwinderjeet,Holzer, Wolfgang,Kumar, Subodh
scheme or table, p. 2706 - 2712 (2009/02/03)
2,3-Diaryl-5-ethylsulfanylmethyltetrahydrofuran-3-ols were designed and synthesized by the allylations of benzoins followed by iodocyclization and nucleophilic replacement reactions with ethanthiol. These molecules exhibit IC50 for COX-2 at 50 over all the 59 human tumor cell lines at μ M concentration. The Royal Society of Chemistry.
2,3,5-Substituted tetrahydrofurans: COX-2 inhibitory activities of 5-hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols
Singh, Palwinder,Mittal, Anu,Kaur, Satwinderjeet,Kumar, Subodh
body text, p. 2792 - 2799 (2009/04/05)
5-Hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols have been investigated for their COX-1 and COX-2 inhibitory activities. Compounds 17, 18 and 20 have been identified as showing appreciable COX-2 inhibition and selectivity. The group present at
Regio- and stereochemical aspects in the synthesis of homoallylic alcohols from benzoins and their iodocyclisation to 2,3-diphenyltetrahydrofurans
Kumar, Subodh,Kaur, Pervinder,Mittal, Anu,Singh, Palwinder
, p. 4018 - 4026 (2007/10/03)
Indium mediated allylation, crotylation and cinnamylation of benzoins and its substituted derivatives in THF-H2O (2/1) provide a range of homoallylic alcohols. In general, the benzoins undergo allylation and crotylation in a sluggish manner com
5-Substituted-2,3-diphenyltetrahydrofurans: A new class of moderately selective COX-2 inhibitors
Singh, Palwinder,Mittal, Anu,Kaur, Satwinderjit,Kumar, Subodh
, p. 7910 - 7916 (2007/10/03)
The nature of C-5 substituent and the configuration at C-5 carbon of 2,3-diphenyltetrahydrofurans, with chiral centres at C-2, C-3 and C-5, show a remarkable influence on their COX-2 inhibition and selectivity. Out of the eight compounds investigated here
Barbier coupling in water: SnCl2-mediated and Co(acac) 2-catalyzed allylation of carbonyls
Chaudhuri, Mihir K.,Dehury, Sanjay K.,Hussain, Sahid
, p. 6247 - 6251 (2007/10/03)
Co(acac)2·2H2O efficiently catalyzes SnCl 2-mediated Barbier coupling in water between carbonyls, including aromatic, aliphatic and α,β-unsaturated aldehydes, ketones, sugars and allyl bromide to afford the corresponding h
Ceric(IV) ammonium nitrate: A novel reagent for the synthesis of homoallyl alcohols
Yadav,Reddy,Krishna,Sadasiv,Chary, Ch. Janardhana
, p. 248 - 249 (2007/10/03)
A rapid and highly efficient method has been developed for the allylation of aldehydes with allyltributylstannane using a catalytic amount of eerie ammonium nitrate in acetonitrile under mild and neutral conditions to afford the corresponding homoallyl al
Remarkable enhancement of Lewis acidity of chlorosilane by the combined use of indium(III) chloride
Onishi, Yoshiyuki,Ito, Takeshi,Yasuda, Makoto,Baba, Akio
, p. 8227 - 8235 (2007/10/03)
A combination of InCl3 and R3SiCl provided a strong Lewis acid catalyst for such reactions as allylation, hydrosilation and Friedel-Crafts alkylation. Especially, catalytic Sakurai-Hosomi-type allylation was accomplished with high yield and selectivity. The silicon atom is assumed to be the acidic center of the combined system, and the catalytic activity largely depends on the substituents on the silicon center.
