127053-50-3

Upstream product

• 6049-47-4 5-oxo-3-phenylhexanoic acid 
• 64-17-5 ethanol 
• 56011-30-4 1-bromo-4,4-dimethylpentan-3-one 
• 29636-75-7 3-bromo-1-phenylpropan-1-one 
• 41848-64-0 3-bromo-1,2-diphenylpropan-1-one 
• 113337-82-9 (E)-5-(tert-Butyl-dimethyl-silanyloxy)-3-phenyl-hex-4-enoic acid ethyl ester 
• 927-80-0 1-ethoxyacetylene 
• 1896-62-4 (E)-benzalacetone 
• 36298-55-2 (4Z)-4-benzylidene-3-methylisoxazol-5(4H)-one 
• 72223-17-7 1-trimethylsilyloxy-1,2-diphenylethylene 
• 79990-96-8 ((1,3-diphenylprop-1-en-2-yl)oxy)trimethylsilane 
• 4354-90-9 (3-oxo-1-phenyl-butyl)-malonic acid 
• 42201-84-3 1-ethoxy-1-(tert-butyldimethylsilyloxy)ethene 
• 1261085-76-0 5-acetyl-6-methyl-4-phenyl-3,4-dihydro-2H-pyran-2-one 

Downstream Products

• 493-72-1 5-phenyl-cyclohexane-1,3-dione 

Relevant academic research and scientific papers

DBU-Catalyzed Ring-Opening and Retro-Claisen Fragmentation of Dihydropyranones

We present a general protocol for the formal Michael addition of acetone to α,β-unsaturated esters and amides, a transformation difficult to perform using current methods. The protocol comprises of an amidine catalyzed relay ring-opening and fragmentation

Highly effective vinylogous Mukaiyama-Michael reaction catalyzed by silyl methide species generated from 1,1,3,3-tetrakis(trifluoromethanesulfonyl)propane

(Chemical Equation Presented) Silyl methide species in situ generated from 1,1,3,3-tetrakis(trifluoromethanesulfonyl)propane (Tf2CHCH 2CHTf2) performed as an excellent acid catalyst for the vinylogousMukaiyama-Michael reaction of α,β-unsaturated ketones with 2-silyloxyfurans. Notably, the required loading of Tf2CHCH 2CHTf2 to obtain the 1,4-adducts in reasonable yield was significantly low (from 0.05 to 1.0 mol%). This carbon acid-mediatedVMMreaction provides a powerful synthetic methodology to construct highly substituted γ-butenolide structure. 2010 American Chemical Society.

A general organocatalytic enantioselective malonate addition to α,β-unsaturated enones

A general enantioselective organocatalytic conjugate addition procedure of a variety of malonates to α,β-unsaturated enone systems is presented. The reaction is efficiently catalysed by the pyrrolidinyl tetrazole catalyst 1. Cyclic, acyclic and aromatic e

NOVEL REFORMATSKY REACTIONS OF 3-ARYLMETHYLENE-4,5-DIHYDRO-2(3H)-FURANONES AND 4-ARYLMETHYLENE-3-METHYL-5(4H)-ISOXAZOLONES

New avenues for enlarging the scope of Reformatsky reaction have been explored by reacting the title compounds with α-halogenoalkanoates in the presence of zinc.

The Michael-type Reaction of B-Iodo-9-BBN/Ethoxyethyne Adduct to α,β-Unsaturated Ketones. A Selective Synthesis of δ-Keto Esters

The adduct formed from B-iodo-9-borabicyclononane and ethoxyethyne reacts with α,β-unsaturated ketones under mild conditions to give δ-keto esters in excellent yield selectively.

An Efficient and Convenient Method for the Preparation of α-Methylenated Ketones from Silyl Enol Ethers

In the presence of a catalytic amount of stannous halide, silyl enol ethers react with bromomethyl methyl ether to give the corresponding α-bromoethyl ketones, which are smoothly converted to α-methylenated ketones on the successive addition of tertiary amine by one-pot procedure.This method is successfully applied to a synthesis of sarkomycin intermediate.