127787-73-9

Upstream product

• 7446-70-0 aluminium trichloride 
• 91-20-3 naphthalene 
• 2051-90-3 Dichlorodiphenylmethane 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 630-95-5 1-naphthyldiphenylmethanol 
• 642-29-5 1-benzoylnaphthalene 
• 71-43-2 benzene 
• 760999-35-7 1,2-di-[1]naphthyl-1,1,2,2-tetraphenyl-ethane 
• 75-36-5 acetyl chloride 

Downstream Products

• 1206795-95-0 C₃₀H₂₈O 
• 1333506-69-6 diethyl 2-(1-(diphenylmethylene)-1,2-dihydronaphthalen-2-yl)malonate 
• 35645-46-6 1-[(1-naphthyl)diphenylmethyl]imidazole 
• 630-95-5 1-naphthyldiphenylmethanol 
• 127787-70-6 dimethyl (1-naphthyldiphenylmethyl)phosphonate 
• 760999-35-7 1,2-di-[1]naphthyl-1,1,2,2-tetraphenyl-ethane 
• 75774-82-2 (1-naphthyl)diphenylmethylamine 
• 104601-29-8 11-phenylbenzofluorene 

Relevant academic research and scientific papers

Nucleophilic dearomatization of chloromethyl naphthalene derivatives via η3-benzylpalladium intermediates: A new strategy for catalytic dearomatization

Palladium-catalyzed nucleophilic dearomatization of chloromethyl naphthalene derivatives to produce ortho- or para-substituted carbocycles in satisfactory to excellent yields has been developed. The unprecedented dearomatization reactions proceeded smoothly under mild conditions via η3-benzylpalladium intermediates.

The absolute configuration of simple aliphatic alcohols through a chemical/computational approach: triarylether derivatives of (+)-endo-2-norborneol as a case study

The reliable determination of the absolute configuration of (+)-endo-2-norborneol 1, chosen as a representative case of simple aliphatic UV-vis transparent alcohols, was obtained by transforming this compound in its 1-naphthyl-diphenylmethyl ether 5 whose

Influence of some novel N-substituted azoles and pyridines on rat hepatic CYP3A activity

A series of N-substituted heteroaromatic compounds structurally related to clotrimazole was synthesized, and the effects of these compounds on ethosuximide clearance in rats were determined as a measure of their abilities to induce cytochrome P4503A (CYP3A) activity. Ethosuximide clearance and in vitro erythromycin N-demethylase activity were shown to correlate. In this series, imidazole or other related heteroaromatic 'head groups' were linked to triphenylmethane or other phenylmethane derivatives. Within the series, it was found that 1-triphenylmethane-substituted imidazoles elicited the greatest increase in CYP3A activity, and that among the triphenylmethyl-substituted imidazoles, the highest activities were achieved by the substitution of F- or Cl- in either the meta or para position of one of the phenyl rings. Diphenylmethylsubstituted pyridine was effectively devoid of activity. Compounds eliciting the largest increase in CYP3A activity (viz. 1-[(3-fluorophenyl)diphenylmethyl]imidazole, 1-[(4- fluorophenyl)diphenylmethyl]imidazole, and 1-[tri-(4- fluorophenyl)methyl]imidazole) produced little or no increase in ethoxyresorufin O-dealkylase (EROD) activity (i.e. CYP1A), whereas benzylimidazole, which elicited only a small increase in CYP3A activity, produced an almost 9-fold increase in CYP1A activity. For a series of eleven compounds exhibiting a wide range of influence on CYP3A activity, a positive correlation was found between ethosuximide clearance and hepatic CYP3A mRNA levels.