128474-79-3

Upstream product

• 124156-34-9 1-p-anisyl-3-isopropylidene-4-carbomethoxy-2-azetidinone 
• 124175-15-1 cis-1-p-anisyl-3-(1'-methylvinyl)-4-carbomethoxy-2-azetidinone 
• 124156-20-3 (4-methoxyphenyl-benzylidene)-carbamic acid methyl ester 
• 108-12-3 isopentanoyl chloride 
• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 124156-28-1 cis-3-isopropyl-1-(4-methoxyphenyl)-4-oxoazetidine-2-carboxylic acid 
• 129374-75-0 cis-4-(Hydroxymethyl)-3-isopropyl-1-(4-methoxyphenyl)azetidin-2-one 
• 133505-01-8 cis-1-(p-methoxyphenyl)-3-isopriopyl-4-formyl-2-azetidinone 
• 123003-79-2 1-p-anisyl-3-isopropyl-4-acetoxy-2-azetidinone 
• 82290-87-7 3-isopropyl-4-acetoxy-2-azetidinone 

Relevant academic research and scientific papers

The acid chloride-iminoester condensation: A direct approach to PS-5 and PS-6 intermediates and related compounds

The dehydrochlorination of alkanoyl chlorides with triethylamine in the presence of α-iminoesters produced 3-alkyl-4-alkoxycarbonyl β-lactams in excellent yields and high stereoselectivity.

β-Lactams via α,β-Unsaturated Acid Chlorides: Intermediates for Carbapenem Antibiotics

Stereocontrolled synthesis of α-vinyl β-lactams and their transformation to convenient intermediates for PS-5, PS-6, asparenomycin, and thienamycin are described.