1289646-93-0

Usage

Uses

Used in Pharmaceutical Synthesis:
6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1) is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and properties make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, this quinoline derivative is utilized for the design and synthesis of novel bioactive molecules. Its chemical versatility allows for the creation of diverse chemical entities with potential applications in treating various diseases and medical conditions.
Used in Drug Discovery:
6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1) plays a crucial role in drug discovery processes. It serves as a starting material or a scaffold for the development of new drug candidates, which can be further optimized for improved potency, selectivity, and pharmacokinetic properties.
Used in Chemical Synthesis:
Apart from its applications in pharmaceuticals and medicine, 6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1) also finds use in various chemical synthesis processes. Its unique structure and reactivity make it a valuable component in the synthesis of other organic compounds and materials.

Upstream product

• 37148-48-4 1-(4-amino-3,5-dichlorophenyl)-1-ethanone 
• 608-31-1 2,6-Dichloroaniline 
• 117738-75-7 3,5-dichloro-4-bromobenzoic acid 
• 1194550-56-5 5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 
• 1289646-72-5 C₂₈H₂₃Cl₂N 
• 73075-47-5 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 14046-52-7 N-(2-chloroethyl)-3,5-dichlorobenzylamine hydrochloride 
• 10203-08-4 3,5-dichlorobenzaldehyde 
• 89315-56-0 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline 
• 73075-58-8 5,7-dichloro isoquinoline 
• 1000210-73-0 (3,5-dichloro-benzylidene)-(2,2-diethoxy-ethyl)-amine 

Downstream Products

• 851784-82-2 2-(tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 
• 1194550-65-6 benzyl (S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-[3-(methylsulfonyl)phenyl]propanoate hydrochloride 
• 1194550-67-8 ((S)-benzyl 2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-methylsulfonyl)phenyl)propanoate 
• 1025967-78-5 (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid 

Relevant academic research and scientific papers

Scalable Process for Making 5,7-Dichlorotetrahydroisoquinoline-6-carboxylic Acid Using Methylene as the Protecting Group

The development of an industrially scalable synthetic route for 5,7-dichlorotetrahydroisoquinoline-6-carboxylic acid (1), a key starting material for lifitegrast, is described. This route includes the following features: (1) tetrahydroisoquinoline19was pr

Synthesis method of 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride

The invention relates to the field of organic synthesis, and discloses a synthesis method of 2,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride. The method comprises the following steps: (1) protecting a benzyl group: reacting 5,7

3,5-dichloro-4-bromoisoquinoline derivative, and preparation method and application thereof

The invention specifically relates to a novel compound, i.e., a 3,5-dichloro-4-bromoisoquinoline derivative, and a preparation method and application thereof, belonging to the technical field of pharmaceutical synthesis. 3,5-dichloro-4-bromoisoquinoline and the derivative thereof are obtained by ring closure of 3,5-dichloro-4-bromobenzene haloethylamine through a Friedel-Crafts alkylation reaction. The 3,5-dichloro-4-bromoisoquinoline and the derivative can be used for synthesizing the important intermediate 3,5-dichloro-4-carboxylisoquinoline of Lifitegrast. According to a technical scheme in the invention, low-cost and well-supplied 2,6-dichloroaniline is used as a starting material; and the preparation method comprises a plurality steps of reactions with mild conditions, mature operation and yield of 85% or more, and each step of reaction has passed pilot-scale test, so the feasibility of industrial conversion of the method is very high and overall production cost can be greatly reduced.

LFA-1 INHIBITOR AND POLYMORPH THEREOF

Methods of preparation and purification of a compound, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA -1 mediated diseases are also disclosed.