128994-25-2

Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-((2-chlorophenoxy)methyl)oxirane is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique chemical structure allows for the creation of a wide range of therapeutic agents, contributing to the development of novel treatments for different medical conditions.
Used in Agrochemical Industry:
In the agrochemical industry, (S)-2-((2-chlorophenoxy)methyl)oxirane serves as an essential intermediate in the production of various agrochemicals. Its incorporation into these products aids in enhancing crop protection, yield, and overall agricultural productivity.
Safety Precautions:
It is crucial to handle and store (S)-2-((2-chlorophenoxy)methyl)oxirane with care, as it can cause irritation to the skin, eyes, and respiratory system. Additionally, proper management and disposal of (S)-2-((2-CHLOROPHENOXY)METHYL)OXIRANE are necessary to minimize potential environmental hazards.

Upstream product

• 2212-04-6 1-(2-chlorophenoxy)-2,3-epoxypropane 
• 124-38-9 carbon dioxide 
• 95-57-8 2-monochlorophenol 
• 57044-25-4 (R)-oxiranemethanol 
• 173597-01-8 (R)-4-(2-Chloro-phenoxymethyl)-2,2-dimethyl-[1,3]dioxolane 
• 148552-91-4 (S)-3-(2-chlorophenoxy)propane-1,2-diol 
• 173597-02-9 Toluene-4-sulfonic acid (R)-3-(2-chloro-phenoxy)-2-hydroxy-propyl ester 
• 115314-14-2 (R)-glycidyl nosylate 
• 115314-14-2 (2s)-(+)-glycidyl 3-nitrobenzenesulfonate 

Downstream Products

• 282099-34-7 2-(4-{3-hydroxy-(2S)-2-[(2S)-2-hydroxy-3-(2-chlorophenoxy) propylamino]-propyl}phenoxy)nicotinamide 

Relevant academic research and scientific papers

Chiral Bifunctional Metalloporphyrin Catalysts for Kinetic Resolution of Epoxides with Carbon Dioxide

Chiral binaphthyl-strapped Zn(II) porphyrins with triazolium halide units were synthesized as bifunctional catalysts for kinetic resolution of epoxides with CO2. Several catalysts were screened by changing the linker length and nucleophilic counteranions, and the optimized catalyst accelerated the enantioselective reaction at ambient temperature to produce optically active cyclic carbonates and epoxides.

Bacillus alcalophilus MTCC10234 catalyzed enantioselective kinetic resolution of aryl glycidyl ethers

The phenyl glycidyl ether derivatives have been kinetically resolved with the growing cells of Bacillus alcalophilus MTCC10234 yielding (S)-epoxides with up to >99% ee and (R)-diols with up to 89% ee. The enantiomeric ratio (E) of up to 67 has been obtained for biohydrolysis process. The effect of different substituents of phenyl glycidyl ether on the biocatalytic efficiency of B. alcalophilus MTCC10234 showed preference for methyl- and chloro-substituted aryl glycidyl ether derivatives whereas nitro-derivatives were transformed at a slower rate. 2,6-Dimethylphenyl glycidyl ether which contains a bulky aryl group having methyl group on both the ortho positions was resolved with an E=39.

LIGANDS FOR CARDIAC BETA1 ADRENOCEPTOR FOR IMAGING CONGESTIVE HEART FAILURE

Novel β1 adrenoreceptor ligands that find use as imaging agents within nuclear medicine applications (e.g., PET imaging and SPECT imaging) are provided. Methods of imaging, including methods of imaging congestive heart failure, are also provide

Jacobsen-type enantioselective hydrolysis of aryl glycidyl ethers. 31P NMR analysis of the enantiomeric composition of oxiranes

The enantioselective partial hydrolysis of a number of racemic aryl glycidyl ethers in the presence of chiral Co(salen)-catalyst was studied. The enantiomeric composition of the isolated (R)-aryl glycidyl ethers was analyzed by 31P NMR using optically active substituted 2-chloro-1,3,2- dioxaphospholanes. A synthesis of β-adrenoblocking agents (S)-toliprolol and (S)-moprolol based on the simultaneously obtained (S)-3-aryloxypropane-1,2- diols was proposed.

Studies on agents with vasodilator and β-blocking activities. III synthesis and activity of optical isomers of TZC-1370

Optical isomers of TZC-1370 (1) were prepared from (R)- and (S)-1-(2- chlorophenoxy)-2,3-epoxypropane. When given intravenously to anesthetized rats, the (S)-isomer was about 40 times more potent in terms of β-blocking activity than the (R)-isomer, while