148552-91-4

Basic information

• Product Name: (S)-3-(2-chlorophenoxy)propane-1,2-diol
• Synonyms: (S)-3-(2-chlorophenoxy)propane-1,2-diol
• CAS NO: 148552-91-4
• Molecular Weight: 202.638
• Mol File: 148552-91-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (S)-3-(2-chlorophenoxy)propane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(2-chlorophenoxy)propane-1,2-diol(148552-91-4)
• EPA Substance Registry System: (S)-3-(2-chlorophenoxy)propane-1,2-diol(148552-91-4)

Safety Data

• Hazardous Substances Data: 148552-91-4(Hazardous Substances Data)

Upstream product

• 95-57-8 2-monochlorophenol 
• 556-52-5 oxiranyl-methanol 
• 2212-04-6 1-(2-chlorophenoxy)-2,3-epoxypropane 
• 57044-25-4 (R)-oxiranemethanol 
• 206259-32-7 (4R,5R)-2-chloro-N,N,N',N'-tetramethyl-1,3,2-dioxaphospholane-4,5-dicarboxamide 
• 173597-01-8 (R)-4-(2-Chloro-phenoxymethyl)-2,2-dimethyl-[1,3]dioxolane 

Downstream Products

• 128994-25-2 (S)-(+)-1-(2-chlorophenoxy)-2,3-epoxypropane 
• 173597-02-9 Toluene-4-sulfonic acid (R)-3-(2-chloro-phenoxy)-2-hydroxy-propyl ester 

Relevant articles and documents

Bacillus alcalophilus MTCC10234 catalyzed enantioselective kinetic resolution of aryl glycidyl ethers

The phenyl glycidyl ether derivatives have been kinetically resolved with the growing cells of Bacillus alcalophilus MTCC10234 yielding (S)-epoxides with up to >99% ee and (R)-diols with up to 89% ee. The enantiomeric ratio (E) of up to 67 has been obtained for biohydrolysis process. The effect of different substituents of phenyl glycidyl ether on the biocatalytic efficiency of B. alcalophilus MTCC10234 showed preference for methyl- and chloro-substituted aryl glycidyl ether derivatives whereas nitro-derivatives were transformed at a slower rate. 2,6-Dimethylphenyl glycidyl ether which contains a bulky aryl group having methyl group on both the ortho positions was resolved with an E=39.

Crystallization of chiral compounds 3. 3-Phenoxypropane-1,2-diol and 3-(2-halophenoxy)propane-1,2-diols

Specific features of melting of crystalline samples of 3-(2-R-phenoxy) propane-1,2-diols with different enantiomeric compositions were studied by differential scanning calorimetry. The melting points and enthalpies of melting for the racemate and individual stereoisomers were determined. Binary phase diagrams were constructed. The entropy of mixing of individual enantiomers in the liquid phase and the free energy of formation of the racemic compound were calculated. The thermochemical data indicate that the racemates are formed upon the crystallization of phenoxy-and 2-fluorophenoxy-containing compounds, while crystallization of the chloro-, bromo-, and iodo-substituted analogs would form racemic conglomerates.

Systematic search for conglomerates among glycerol aromatic monoethers: Guaifenesin and mephenesin are the cases

Within the family of biologically active 3-aryloxy-1,2-propanediols, three new conglomerate-forming compounds have been found and resolved into enantiomers using the entrainment procedure.