130286-84-9Relevant academic research and scientific papers
Reactivity of (poly)fluorobenzamides in palladium-catalysed direct arylations
Laidaoui, Nouria,He, Mian,El Abed, Douniazad,Soulé, Jean-Fran?ois,Doucet, Henri
, p. 62866 - 62875 (2016)
The influence of fluoro-substituents on secondary and tertiary benzamides on the regioselectivity of palladium-catalysed direct arylations was studied. With most (poly)fluoro-substituted tertiary benzamides, the arylations proceed very regioselectively at ortho-positions of the fluoro substituents using 1 mol% of air-stable palladium catalysts and PivOK/DMA as the reaction conditions. With the 3,5-difluoro-substituted secondary benzamides, quite regioselective arylations at C4-positions were observed. For these reactions, a variety of substituents on the aryl bromide, such as ester, propionyl, acetyl, formyl, nitro, nitrile, trifluoromethyl, chloro, fluoro or methyl, was tolerated. These results reveal that under our reaction conditions, fluoro substituents act as better directing groups than amides in the palladium-catalysed direct arylations.
Synthesis method of baloxavir marboxil intermediate
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Paragraph 0062-0063, (2019/08/30)
The invention provides a synthesis method of a baloxavir marboxil intermediate. The invention provides a synthesis method of a compound (III), which is prepared through three steps. The yield is improved, and the production is easy to control. At the same
ORGANIC COMPOUNDS
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Page/Page column 106-107, (2008/06/13)
The present invention provides a compound of formula (I):said compound is inhibitor of aldosterone synthase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, increased formation of collagen, cardiac fibrosis and remodeling following hypertension and endothelial dysfunction. Finally, the present invention also provides a pharmaceutical composition.
POLYFLUORINATED CONDENSED AROMATIC COMPOUND AND USE THEREOF IN LIQUID CRYSTAL MIXTURE
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Page/Page column 17, (2010/02/15)
PROBLEM TO BE SOLVED: To provide a polyfluorinated condensed aromatic compound and a liquid crystal mixture. SOLUTION: The liquid crystal mixture contains a compound of formula (I) [wherein, for example, R1 is H, propyl or butyloxy; R2 is propyl; p and q are each 1; and r is 0 or 1].
