2136287-65-3

Usage

Uses

Used in Pharmaceutical Industry:
3,4-difluoro-2-((phenylthio)methyl)benzoic acid is used as a building block in organic synthesis for the development of new molecules with specific biological activities. Its fluorinated and thiol-containing moieties make it a promising candidate for the creation of novel drug candidates with improved efficacy and selectivity in treating various diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 3,4-difluoro-2-((phenylthio)methyl)benzoic acid is utilized as a precursor in the synthesis of new agrochemicals. Its unique structure and properties can contribute to the development of more effective and selective pesticides, herbicides, or other agrochemicals that can enhance crop protection and yield.
Used in Fluorine and Sulfur Chemistry Research:
3,4-difluoro-2-((phenylthio)methyl)benzoic acid is also used as a model compound for studying fluorine and sulfur chemistry in biological systems. Its presence of fluorine and sulfur atoms allows researchers to explore their interactions with biological molecules, potentially leading to a better understanding of their roles in various biological processes and the development of new therapeutic agents or agrochemicals based on these findings.
Overall, the diverse applications of 3,4-difluoro-2-((phenylthio)methyl)benzoic acid highlight its potential as a versatile compound in various industries, with ongoing research and development expected to uncover even more uses and benefits.

Upstream product

• 882-33-7 diphenyldisulfane 
• 130286-84-9 N,N-diethyl-3,4-difluorobenzamide 
• 930-69-8 sodium thiophenolate 
• 348-61-8 1-bromo-3,4-difluorobenzene 
• 157652-31-8 3,4-difluoro-2-methyl benzoic acid 
• 108-98-5 thiophenol 
• 160775-14-4 3,4-difluoro-2-methylbenzoic acid methyl ester 
• 3828-49-7 1,2-difluoro-3-methyl-benzene 
• 847502-81-2 1-bromo-3,4-difluoro-2-methyl-benzene 
• 847502-83-4 3,4-difluoro-2-methylbenzonitrile 
• 1807193-48-1 1-bromo-2-(bromomethyl)-3,4-difluorobenzene 
• 651326-72-6 (6-bromo-2,3-difluorophenyl)methanol 
• 124-38-9 carbon dioxide 

Downstream Products

• 2136287-66-4 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-one 
• 1985607-83-7 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepine-11-ol 
• 1985605-59-1 (R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione 

Relevant academic research and scientific papers

Preparation method of sulfur-containing hetero-seven-membered ring compound

The invention relates to a preparation method of a sulfur-containing hetero-seven-membered ring compound. The method comprises the following steps: carrying out halogenation reaction, nucleophilic substitution, acylation, cyclization, reduction and the li

Pyridone-containing polycyclic derivative inhibitor as well as preparation method and application thereof

The invention relates to a pyridone-containing polycyclic derivative inhibitor as well as a preparation method and an application thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method

Method for preparing baloxavir intermediate and intermediate obtained by method

The invention belongs to the technical field of chemical synthesis, and provides a method for preparing a balosavir intermediate. The method comprises the following steps: (1) methylating 3,4-difluorobromobenzene to obtain a compound A-1; (2) reacting the compound A-1 with a Grignard reagent, then introducing carbon dioxide gas for reaction, and adding acid for acidification to obtain a compound A-2; (3) brominating the compound A-2 to obtain a compound A-3; (4) adding diphenyl disulfide and a reducing agent 1 into THF, dropwise adding methanol, dropwise adding the compound A-3, and reacting to obtain a compound A-4; (5) carrying out ring closing reaction on the compound A-4 in polyphosphoric acid to obtain a compound A-5; and (6) reducing the compound A-5 into alcohol by adopting a reducing agent 2 to obtain a compound A-6. According to the method, highly toxic and foul thiophenol is prevented from being used while expensive reagents are prevented from being used, so that the processcost is reduced. The invention also provides an intermediate compound prepared by the method.

Method for synthesizing 3,4-difluoro-2-((thiophenyl)methyl)benzoic acid

The invention discloses a preparation method of a Baloxavir marboxil key intermediate, namely 3,4-difluoro-2-((thiophenyl)methyl)benzoic acid. The method comprises the following steps: by taking 3,4-difluoro-2-methyl benzoic acid as a raw material, performing a reflux reaction on the raw material with azodiisobutyronitrile (AIBN) and N-bromosuccinimide (NBS) in a carbon tetrachloride solution so as to obtain 2-bromomethyl-3,4-difluorobenzoic acid, and enabling the 2-bromomethyl-3,4-difluorobenzoic acid to react with sodium thiophenolate or diphenyl disulfide, so as to obtain the 3,4-difluoro-2-((thiophenyl)methyl)benzoic acid. Through the synthesis method, a target product can be obtained through only two steps, and raw materials are easy to obtain, aftertreatment is simple and convenient,and the yield is high.

Preparation method of baloxavir intermediate

The invention relates to a preparation method of a baloxavir intermediate and belongs to the field of medicinal chemistry. With the compound (A) as an initial raw material, the method includes a halogenation reaction, a Grignard reaction, a halogenation r

Xofluza sulfur-containing heterocyclic compound, intermediate and preparation method thereof

The invention discloses an Xofluza sulfur-containing heterocyclic compound, an intermediate and a preparation method thereof, and provides a preparation method of a compound represented by a formula 5. The preparation method is mild in reaction condition,

Preparation method of baloxavir key intermediate and intermediate thereof

The invention discloses a preparation method of a baloxavir key intermediate and the intermediate thereof. The method includes subjecting 3,4-difluoro-2-methyl benzaldehyde shown as a formula (I) as araw material to a bromination reaction to obtain 3,4-di

Sulfur-containing heterocyclic compound preparation method

The invention provides a sulfur-containing heterocyclic compound preparation method, and belongs to the field of medicinal chemical industry. The method comprises: carrying out a reaction on a dewatering reagent and 3,4-difluoro-2-methyl benzoic acid, and

Development of a Quality Controllable and Scalable Process for the Preparation of 7,8-Difluoro-6,11-dihydrodibenzo[ b, e]thiepin-11-ol: A Key Intermediate for Baloxavir Marboxil

A novel six-step synthesis of 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-ol (1) is described. Starting with 3,4-difloro-2-methylbenzoic acid and using diphenyl disulfide as an ideal sulfur source effectively solve the problems such as harsh reaction conditions, usage of smelly thiophenol, which might restrict the known process from pilot plant application. Large-scale applicability of this new route has been successfully demonstrated on kilogram-scale production to afford 1 with 98.04% purity in 75% overall yield. Meanwhile, the corresponding impurity profile was thus studied in detail and well documented.

Preparation method of 7,8-difluoro-6,11-dihydro-dibenzothiophene-11-alcohol

The invention relates to a preparation method of 7,8-difluoro-6,11-dihydro-dibenzothiophene-11-alcohol. According to the method, specifically, 2,3-difluorotoluene is adopted as a raw material, and 7,8-difluoro-6,11-dihydro-dibenzothiophene-11-alcohol is e