1303609-20-2Relevant academic research and scientific papers
Synthesis and Physicochemical Properties of 3-Fluorocyclobutylamines
Chernykh, Anton V.,Radchenko, Dmytro S.,Chernykh, Alla V.,Kondratov, Ivan S.,Tolmachova, Nataliya A.,Datsenko, Olexandr P.,Kurkunov, Maxim A.,Zozulya, Sergey X.,Kheylik, Yuri P.,Bartels, Katharina,Daniliuc, Constantin G.,Haufe, Günter
supporting information, p. 6466 - 6471 (2015/10/19)
Hitherto unknown cis- and trans-3-alkyl- and 3-aryl-3-fluorocycobutylamines have been synthesised selectively from 3-oxocyclobutane carboxylic acid in six or seven steps. Comparison of their pKa and logD values with those of the fluorine-free p
COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS
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, (2015/02/02)
The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors
Zhao, Yujun,Liu, Liu,Sun, Wei,Lu, Jianfeng,McEachern, Donna,Li, Xiaoqin,Yu, Shanghai,Bernard, Denzil,Ochsenbein, Philippe,Ferey, Vincent,Carry, Jean-Christophe,Deschamps, Jeffrey R.,Sun, Duxin,Wang, Shaomeng
supporting information, p. 7223 - 7234 (2013/06/27)
Small-molecule inhibitors that block the MDM2-p53 protein-protein interaction (MDM2 inhibitors) are being intensely pursued as a new therapeutic strategy for cancer treatment. We previously published a series of spirooxindole-containing compounds as a new
SPIRO-OXINDOLE MDM2 ANTAGONISTS
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Page/Page column 148, (2011/05/16)
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as
