130561-87-4Relevant articles and documents
Reaction of gem-Dibromocyclopropanes with Potassium Dimethyl Phosphite in Liquid Ammonia. A Highly Stereoselective Reduction
Meijs, Gordon F.,Doyle, Ian R.
, p. 3713 - 3716 (1985)
Although gem-dibromocyclopropanes undergo subsitution with other SRN1 nucleophiles in liquid ammonia solution stimulated by "350 nm" light, only reduction is observed with dimethyl phosphite ion.This reduction proceeds in the absence of light and involves nonradical intermediates.It gives high yields of the trans monobromides 4 with little or no contamination by the cis isomers 5 or the direduced products 6. gem-Dichlorocyclopropanes are inert under the reaction conditions.The reaction is suited to preparative work.
NMR spectroscopy of organolithium compounds, part XXXIII: trans-2,3-dimethylcyclopropyllithium aggregation in diethylether: An equilibrium between three different complexes of comparable energy and the influence of LiBr on aggregate structure
Fox, Thomas,Günther, Harald
, (2018)
The aggregate formation of trans-2,3-dimethylcyclopropyllithium (2) was studied in diethylether (DEE). With the help of the isotopic fingerprint method three clusters, a monomer, a dimer, and a fluxional tetramer in the ratio 1.00:0.53:0.22 were identified at 187?K. In the presence of 1 equivalent of LiBr cyclopropyllithium (1) forms in DEE at 163?K a mixed dimer and a mixed tetramer, while in THF a mixed dimer dominates. Under the same conditions 2 and 2,2,3,3-tetramethylcyclopropyllithium (3) form in the solvent mixture DEE/THF (1:1) mixed dimers, as does 2 also in THF.
Renk et al.
, p. 1987,1988 (1961)
Novel method for synthesizing cyclopropyl bromide
-
Paragraph 0003; 0010-0012, (2021/10/11)
The invention discloses a novel method for synthesizing cyclopropyl bromide. The method comprises the following steps: by taking bromoethylene as a raw material, carrying out denitrification cyclization reaction on the bromoethylene and diazomethane in a solvent under the action of a Pd(oAc)2 catalyst to obtain a cyclopropyl bromide crude product, and carrying out acid pickling, filtering layering and normal-pressure rectification to obtain a pure product with the content of 99% or more and the yield of 80% or more. The synthesis method has the advantages of mild conditions, few byproducts, high yield and environmental friendliness, and is more suitable for industrial amplification.
Novel method for synthesizing cyclopropyl bromide
-
Paragraph 0013-0018, (2020/05/14)
The invention discloses a novel synthetic method for synthesizing cyclopropyl bromide. A decarboxylation bromination reaction is carried out in a solvent by taking cyclopropanecarboxylic acid as a rawmaterial, lead tetraacetate as a catalyst and metal bromide such as lithium bromide as a bromination reagent to obtain crude cyclopropyl bromide, reduced pressure distillation is carried out on the crude cyclopropyl bromide to obtain a pure product with the content of 99% or above and the yield of 85% or above, the obtained byproduct lead bromide is reacted with ammonium acetate, and the reactionproduct is oxidized to obtain lead tetraacetate for recycling. The synthesis route has the advantages of accessible raw materials, mild conditions, fewer byproducts, high yield and environment friendliness, and is suitable for industrial amplification.
