130780-13-1

Basic information

• Product Name: methyl N-(4-chlorobenzyl)carbamate
• CAS NO: 130780-13-1
• Molecular Weight: 199.637
• Mol File: 130780-13-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl N-(4-chlorobenzyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N-(4-chlorobenzyl)carbamate(130780-13-1)
• EPA Substance Registry System: methyl N-(4-chlorobenzyl)carbamate(130780-13-1)

Safety Data

• Hazardous Substances Data: 130780-13-1(Hazardous Substances Data)

Upstream product

• 104-86-9 4-chlorobenzylamine 
• 79-22-1 methyl chloroformate 
• 67-56-1 methanol 
• 115601-14-4 4-Chlorphenylacetylazid 
• 124-38-9 carbon dioxide 
• 6951-40-2 2-((4-chlorobenzyl)amino)-2-oxoacetic acid 
• 140-53-4 p-chlorobenzyl cyanide 
• 20101-92-2 2-(4-chlorophenyl)acetamide 
• 65398-61-0 O-methyl S-p-bromophenyl thiocarbonate 
• 3186-52-5 O-methyl-S-phenyl thiolcarbonate 
• 3186-65-0 O-methyl S-p-chlorophenyl thiocarbonate 
• 3186-53-6 O-methyl S-p-methylphenyl thiocarbonate 

Relevant articles and documents

Urethanes synthesis from oxamic acids under electrochemical conditions

Urethane synthesis via oxidative decarboxylation of oxamic acids under mild electrochemical conditions is reported. This simple phosgene-free route to urethanes involves an in situ generation of isocyanates by anodic oxidation of oxamic acids in an alcoholic medium. The reaction is applicable to a wide range of oxamic acids, including chiral ones, and alcohols furnishing the desired urethanes in a one-pot process without the use of a chemical oxidant.

Hypervalent iodine catalyzed hofmann rearrangement of carboxamides using oxone as terminal oxidant

Hofmann rearrangement of carboxamides to carbamates using Oxone as an oxidant can be efficiently catalyzed by iodobenzene. This reaction involves hypervalent iodine species generated in situ from catalytic amount of PhI and Oxone in the presence of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) in aqueous methanol solutions. Under these conditions, Hofmann rearrangement of various carboxamides affords corresponding carbamates in high yields.

Facile preparation of protected benzylic and heteroarylmethyl amines via room temperature Curtius rearrangement

A step-wise, room temperature procedure for acyl azide formation and the subsequent Curtius rearrangement of phenyl and heteroaryl acetic acids is described. We have developed a protocol for room temperature Curtius rearrangement in MeOH or CHCl3 that provides an improvement over standard conditions, avoiding the use of additives or heat. This room temperature optimization of the Curtius rearrangement prevents the formation of side products often observed with benzylic acids, allowing access to a variety of benzylic and heteroarylmethyl amines.