130830-73-8 Usage
Uses
Used in Pharmaceutical Industry:
(2S,4S)-1-(Benzyloxycarbonyl)pyrrolidine-2,4-dicarboxylic acid is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of novel drugs with specific biological activities.
Used in Chemical Research:
In the field of chemical research, (2S,4S)-1-(Benzyloxycarbonyl)pyrrolidine-2,4-dicarboxylic acid serves as a valuable intermediate for the development of new chemical entities. Its reactivity and structural features make it a useful tool for exploring new reaction pathways and synthesizing complex molecules.
Used as Transport Inhibitors:
(2S,4S)-1-(Benzyloxycarbonyl)pyrrolidine-2,4-dicarboxylic acid is used as transport inhibitors, which can play a crucial role in understanding and modulating the transport of various molecules across cellular membranes. This application can be particularly relevant in the study of drug resistance mechanisms and the development of strategies to overcome them.
Check Digit Verification of cas no
The CAS Registry Mumber 130830-73-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,8,3 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 130830-73:
(8*1)+(7*3)+(6*0)+(5*8)+(4*3)+(3*0)+(2*7)+(1*3)=98
98 % 10 = 8
So 130830-73-8 is a valid CAS Registry Number.
130830-73-8Relevant academic research and scientific papers
Conformationally Defined Neurotransmitter Analogues. Selective Inhibition of Glutamate Uptake by One Pyrrolidine-2,4-dicarboxylate Diastereomer
Bridges, Richard J.,Stanley, Mark S.,Anderson, Michael W.,Cotman, Carl W.,Chamberlin, A. Richard
, p. 717 - 725 (2007/10/02)
In order to determine the conformational requirements for binding of L-glutamate to the proteins involved in the process of neurotransmission, rigid analogues containing an embedded glutamate moiety have been prepared.These "conformer mimics", the pyrrolidine-2,4-dicarboxylates 4, 7, 11, and 14, were synthesized from commercially available trans-4-hydroxy-L-proline and cis-4-hydroxy-D-proline, and then were tested for their ability to inhibit the high-affinity transport of -L-glutamate into synaptosomes and to block the binding of radioligands to the NMDA (N-methyl-D-aspartate), KA (kainate), and QA (quisqualate) glutamate neurotransmitter receptor sites.While none of the four analogues binds effectively to the excitatory receptors, the L-trans-isomer 7 is a potent and selective competitive inhibitor of L-glutamate transport.These results delineate a specific structural/conformational preference for binding to the uptake system that is distinct from that required for binding to the NMDA, KA, and QA receptors.
