131214-20-5

Basic information

• Product Name: (2Z)-N,N-dimethyl-3-phenyl-2-propenamide
• Synonyms: (2Z)-N,N-dimethyl-3-phenyl-2-propenamide
• CAS NO: 131214-20-5
• Molecular Weight: 175.23
• Mol File: 131214-20-5.mol
• Article Data: 48

Chemical Properties

• CAS DataBase Reference: (2Z)-N,N-dimethyl-3-phenyl-2-propenamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z)-N,N-dimethyl-3-phenyl-2-propenamide(131214-20-5)
• EPA Substance Registry System: (2Z)-N,N-dimethyl-3-phenyl-2-propenamide(131214-20-5)

Safety Data

• Hazardous Substances Data: 131214-20-5(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 127-19-5 N,N-dimethyl acetamide 
• 292638-85-8 acrylic acid methyl ester 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 637-44-5 phenylpropyolic acid 
• 26218-50-8 N,N-dimethyl-3-phenylpropiolamide 
• 536-74-3 phenylacetylene 
• 2680-03-7 N,N-Dimethylacrylamide 
• 108-90-7 chlorobenzene 
• 108-86-1 bromobenzene 
• 103-64-0 bromostyrene 
• 479486-96-9 N,N-dimethyl (trimethylsilyl)methanamide 
• 100-52-7 benzaldehyde 
• 440357-42-6 N,N-dimethyl(triphenylsilyl)acetamide 

Downstream Products

• 78141-09-0 (2S,3S)-2,3-Diphenyl-pentanedioic acid 1-dicyclohexylamide 5-dimethylamide 
• 78141-09-0 (2S,3R)-2,3-Diphenyl-pentanedioic acid 1-dicyclohexylamide 5-dimethylamide 
• 77515-93-6 N,N-Dimethyl-3-phenyl-butyramide 
• 105941-16-0 N,N-dimethylcinnamide-4-sulfonyl chloride 
• 17431-39-9 (E)-N,N-dimethylcinnamamide 
• 621-82-9 Cinnamic acid 
• 17431-40-2 (+/-)-threo-N,N-Dimethyl-2,3-dihydroxy-3-phenyl-propionamid 
• 156638-50-5 (E)-2-(dimethylamino)-4-phenylbut-3-enenitrile 

Relevant articles and documents

Palladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides

A palladium-catalyzed fluorosulfonylvinylation reaction of organic iodides is described. Catalytic Pd(OAc)2 with a stoichiometric amount of silver(I) trifluoroacetate enables the coupling process between either an (hetero)aryl or alkenyl iodide with ethenesulfonyl fluoride (ESF). The method is demonstrated in the successful syntheses of eighty-eight otherwise difficult to access compounds, in up to 99 % yields, including the unprecedented 2-heteroarylethenesulfonyl fluorides and 1,3-dienylsulfonyl fluorides.

Effect of molecular conformation on interaction of organic species in water. Benzamides and anisamides with theophylline and riboflavin.

-

Manganese Catalyzed Enantioselective Epoxidation of α,β-Unsaturated Amides with H2O2

Herewith, we report the enantioselective epoxidation of electron-deficient cis- and trans-α,β-unsaturated amides with the environmentally benign oxidant H2O2. The catalysts - manganese complexes with bis-amino-bis-pyridine and structurally related ligands - exhibit reasonably high efficiency (up to 100 TON) and excellent chemo- and enantioselectivity (up to 100% and 99% ee, respectively). Crucially, the cis-enamides epoxidation enantioselectivity and yield are dramatically enhanced by the presence of NH-moiety, which effect can be explained by the hydrogen bonding interaction between the cis-enamide substrate and the manganese based oxygen transferring species. (Figure presented.).

LIPOXYGENASE INHIBITORS

Various embodiments of the present disclosure are directed to compounds having Formula (I), Formula (IA), Formula (IB), Formula (IC), Formula (ID), Formula (IE), and/or pharmaceutically acceptable salts thereof. The compounds can be suitable for inhibiting lipoxygenases, and/or treating associated diseases, such as Alzheimer's disease. In some embodiments, the compounds may be administered to a patient as part of a pharmaceutical formulation.