13149-04-7Relevant articles and documents
[6+5] FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES
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Page/Page column 43-44, (2012/01/14)
The present invention relates to the new [6+5] fused bicycle derivatives, pharmaceutically acceptable salts or isomers thereof, processes for preparing the same, and pharmaceutical compositions comprising the same. The [6+5] fused bicycle derivatives can antagonize the thrombin receptor and thus may be effectively used for the treatment and prevention of thrombus, platelet aggregation, atherosclerosis, restenosis, blood coagulation, hypertension, arrhythmia, angina pectoris, heart failure, inflammation and cancer when used alone or with other cardiovascular agents.
Total synthesis of Taxol. 2. Construction of A and C ring intermediates and initial attempts to construct the ABC ring system
Nicolaou,Liu,Yang,Ueno,Sorensen,Claiborne,Guy,Hwang,Nakada,Nantermet
, p. 634 - 644 (2007/10/02)
A method for the formation of Taxol's ABC ring system has been developed. General methods for the synthesis of versatile synthons for Taxol's A ring (8) and C ring (55) are presented. A model study using a simplified C ring synthon (17) confirmed the viability of the sequential Shapiro-McMurry strategy for formation of Taxol's B ring. Careful exploration of the chemistry of various A-B ring conjugates allowed the development of a successful method for formation of the B ring in a more functionalized system.
Enantioselectivity of the Microsomal Epoxide Hydrolase Catalyzed Hydrolysis of trans-4,5-Dimethyl-1,2-epoxycyclohexane
Bellucci, Giuseppe,Berti, Giancarlo,Ferretti, Maria,Mastrorilli, Ettore,Silvestri, Luca
, p. 1471 - 1474 (2007/10/02)
The hydrolysis of the racemic and enantiomeric forms of trans-4,5-dimethyl-1,2-epoxycyclohexane, catalyzed by rabbit liver microsomal epoxide hydrolase (EH), has been investigated to clarify further the mechanism of enantioselection by this enzyme.Both ac