13160-07-1

Basic information

• Product Name: N-(2-Pyridyl)nicotinamide
• Synonyms: N-(2-Pyridyl)nicotinamide;N-(2-Pyridinyl)-3-pyridinecarboxamide;N-(pyridin-2-yl)nicotinamide;N-pyridin-2-ylpyridine-3-carboxamide
• CAS NO: 13160-07-1
• Molecular Formula: C11H9N3O
• Molecular Weight: 199.212
• Mol File: 13160-07-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 139-142 ºC
• Boiling Point: 286 ºC
• Flash Point: 127 ºC
• Appearance: /
• Density: 1.287
• Vapor Pressure: 0.0027mmHg at 25°C
• Refractive Index: 1.658
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(2-Pyridyl)nicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Pyridyl)nicotinamide(13160-07-1)
• EPA Substance Registry System: N-(2-Pyridyl)nicotinamide(13160-07-1)

Safety Data

• Hazardous Substances Data: 13160-07-1(Hazardous Substances Data)

Usage

General Description

N-(2-Pyridyl)nicotinamide, also known as 2-Pyridyl-Nicotinamide or N-(Pyridine-2-yl)nicotinamide, is a chemical compound with the molecular formula C12H9N3O. It is a derivative of niacin (vitamin B3) and contains a pyridine ring with a nicotinamide group attached. N-(2-Pyridyl)nicotinamide has been studied for potential therapeutic applications, including as an inhibitor of the enzyme poly(ADP-ribose)polymerase (PARP) and as a chelating agent for metal ions. N-(2-Pyridyl)nicotinamide may also have potential uses in the field of medicinal chemistry and pharmaceutical research due to its structural and biochemical properties. Overall, this compound shows promise for various biomedical and chemical applications due to its unique molecular structure and potential biological activities.

InChI:InChI=1/C11H9N3O/c15-11(9-4-3-6-12-8-9)14-10-5-1-2-7-13-10/h1-8H,(H,13,14,15)

Upstream product

• 504-29-0 2-aminopyridine 
• 1120-90-7 3-iodopyridine 
• 201230-82-2 carbon monoxide 
• 626-55-1 3-Bromopyridine 
• 13939-06-5 molybdenum hexacarbonyl 
• 500-22-1 3-pyridinecarboxaldehyde 
• 109-09-1 2-chloropyridine 
• 98-92-0 nicotinamide 
• 109-04-6 2-bromo-pyridine 
• 59-67-6 nicotinic acid 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 10400-19-8 3-pyridinecarbonyl chloride 

Downstream Products

• 1374639-87-8 phenyl (2-(pyridin-3-yl)imidazo[1,2-a]pyridin-3-yl)methanone 

Relevant articles and documents

1H and 13C NMR spectral studies of conformation of some N-(2-pyridinyl)-3-pyridinecarboxamides

The 1H and 13C NMR spectra of N-(2-pyridinyl)-, N-(4-methyl2-pyridinyl)-, and N-(6-methyl-2-pyridinyl)-3-pyridinecarboxamides (1-3, respectively) and 3-pyridinecarboxamide (4) in different solvents have been analysed using COSY, HETCOR, chemical shift and coupling constant correlations. The conformations of 1-4 have been obtained by utilizing the NMR spectra, NOE experiments and MINDO/3 calculations. In dilute solutions, the 2-pyridyl ring is coplanar with the amide group while the 3-pyridyl ring is apparently not. Compounds 1-3 dimerize through cooperative hydrogen bonding in concentrated CDCl3 solution (approximately 0.1 M) and the structure of the dimer resembles some of the DNA base-pairs. Hydrogen bonding between N-H and the solvent molecules hinders dimerization in (CD3)2CO and CD3CN.

1H and 13C NMR Study of N-(3-pyridinyl)-2-pyridinecarboxamide and N,N′-bis(2-pyridinyl)-1,3-benzenedicarboxamide

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Mapping out the Relative Influence of Hydrogen and Halogen Bonds in Crystal Structures of a Family of Amide-Substituted Pyridines

The simultaneous use of hydrogen bonds and halogen bonds in crystal engineering strategies has previously been employed in order to generate new solid forms with applications in e.g. pharmaceutical and agrochemical industries. Unfortunately, it is not eas

Microwave-assisted heteropolyanion-based ionic liquid promoted sustainable protocol to N-heteroaryl amides via N-directing dual catalyzed oxidative amidation of aldehydes

A sustainable procedure for the synthesis of N-heteroaryl amides directly from oxidative amidation of aldehydes catalyzed by heteropolyanion-based ionic liquids under microwave-promoted conditions has been reported. The transformation has proven to tolerate a wide range of aldehydes and amino heterocycles with different functional groups. Moderate to excellent yields, solvent-free media, operational simplicity and reusability of catalysts are the main highlights. Furthermore, the proposed N-directing dual-catalysis mechanistic pathway was briefly investigated in this report.