132797-26-3

Upstream product

• 6261-32-1 (E)-2-benzylidene-1-tetralone 
• 6261-32-1 2-benzylidene-1-tetralone 
• 64-19-7 acetic acid 
• 78140-78-0 ethyl 2-benzyl-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate 
• 100-44-7 benzyl chloride 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 6742-26-3 2-ethoxycarbonyl-1-tetralone 
• 529-33-9 1,2,3,4-Tetrahydro-1-naphthol 
• 100-51-6 benzyl alcohol 
• 38858-72-9 1-trimethylsiloxy-3,4-dihydronaphthalene 
• 100-39-0 benzyl bromide 
• 1314305-54-8 2-benzyl-1-(trifluoroacetoxy)tetral-1-ene 
• 119-64-2 tetralin 
• 91-01-0 1,1-Diphenylmethanol 

Downstream Products

• 27019-09-6 2-benzyl-1,2,3,4-tetrahydro-naphthalene 
• 78140-79-1 trans-2-benzyl-1,2,3,4-tetrahydronaphthalene-1-ol acetate 
• 78140-79-1 Acetic acid (1R,2S)-2-benzyl-1,2,3,4-tetrahydro-naphthalen-1-yl ester 
• 247913-11-7 (S)-2-benzyl-2-fluoro-3,4-dihydro-2H-naphthalen-1-one 
• 6340-82-5 2,2-dibenzyl-3,4-dihydronaphthalen-1(2H)-one 
• 147328-49-2 1-trimethylsilyloxy-2-benzyl-tetral-1-ene 
• 91-20-3 naphthalene 
• 1314305-54-8 2-benzyl-1-(trifluoroacetoxy)tetral-1-ene 
• 157485-34-2 (S)-2-benzyl-1-tetralone 
• 6261-33-2 cis-2-benzyl-1,2,3,4-tetrahydronaphthalene-1-ol 

Relevant academic research and scientific papers

An approach to catalytic enantioselective protonation of prochiral lithium enolates

Protonation of prochiral lithium enolates (4), prepared from racemic 2-substituted-1- tetralones (2) via their silyl enol ethers (3), with excess succinimide in the presence of lithium bromide and 0.2 equivalent of a chiral tetradentate amine ((R)-1) in toluene at -78°C gave optically active 2 in up to 83% ee.

Enantioselective Protonation of Achiral Lithium Enolates Using a Chiral Amine in the Presence of Lithium Bromide

Asymmetric synthesis of 2-alkyl-1-tetralones (2) was achieved in up to 91percent e.e. by enantioselective protonation of their corresponding achiral lithium enolates (4) using a chiral amine ((R)-1) as a chiral source in the presence of lithium bromide.En

Stereoselective reactions. Part 31: Catalytic asymmetric alkylation of achiral lithium enolates using a chiral tetradentate amine in the presence of an achiral bidentate amine

Catalytic asymmetric alkylation of achiral lithium enolates of 1- tetralone and cyclohexanone with reactive alkyl halides was realized by using a combination of a chiral tetradentate amine (~0.05 equiv.) and an achiral bidentate amine (2 equiv.).

Rate enhancement with high ratio of the monoalkylated product to the dialkylated product in the alkylation of the lithium enolate of 1-tetralone with reactive alkyl halides

The reactions of the lithium enolate of 1-tetralone with reactive alkyl halides were examined in the absence and in the presence of 3 eq of various ligands for the lithium. It is shown that the rates of the reactions are enhanced greatly in the presence a tetradentate amine (1,1,4,7,10,10-hexamethyltriethylenetetramine), and the ratio of the monoalkylated product to the dialkylated product is increased under shorter reaction times.

Catalytic asymmetric protonation of achiral lithium enolates mediated by a chiral tetraamine ligand with water as a proton source

Catalytic protonation of achiral lithium enolates (derived from 2- substituted-1-tetralones), mediated by a chiral tetraamine ligand [(R,R)- N,N'-bis[1-phenyl-2-(1-piperidinyl)ethyl]-1,3-propanediamine (0.10 equiv.)], was achieved with high enantioselecti

Why is alkylation of an enolate accompanied by so much polyalkylation?

(Equation presented) The lithium enolate 1-Li of 6-phenyl-α-tetralone forms a monomer-tetramer equilibrium in THF at 25 °C with K1,4 = 4.7E+10 M-3. The lithium enolate 2-Li, however, forms a monomer-dimer equilibrium with K1,2/

Regioselective reduction of the homoisoflavone system with dialkylboranes in the presence of palladium catalysts

(E)-3-Benzylidene-4-chromanones were regioselectively reduced to 3- benzyl-4-chromanones through the 1,4-addition of dialkylboranes, especially 9-borabicyclo[3.3.1]nonane, in excellent yields. The reaction was efficiently promoted by some palladium cataly

Highly enantiofacial protonation of prochiral lithium enolates with chiral β-hydroxy sulfoxides

Highly enantioselective protonation of prochiral lithium enolates is disclosed. The present method employed (S,R(s)) CF3-hydroxy sulfoxide (3b) as the chiral protonating agent, and the protonation or lithium enolates of cyclohexanone derivatives with 3b proceeded with high enantioselectivities.

1,1,4,7,10,10-Hexamethyltriethylenetetramine: A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides

The rate of the reaction of the lithium enolate of 1-tetralone with alkyl halides was enhanced greatly in the presence of 3 equivalents of 1,1,4,7,10,10-hexamethyltriethylenetetramine. The ratio of the monoalkylated product to the dialkylated product was found to have increased under a shorter reaction time.

Efficient asymmetric protonation of enolates with readily accessible chiral α-sulfinyl alcohols

The efficient asymmetric protonation of lithium enolates of 2- alkylcycloalkanones (87-96% ee) with readily accessible chiral α-sulfinyl alcohols is described. Optimal stereoselection is achieved for each lithium enolate at a different reaction temperature in the range -40 to -100°C.