132816-01-4

Upstream product

• 137438-51-8 4-(benzyloxy)-4-phenyl-1-butene 
• 80735-94-0 1-Phenyl-3-buten-1-ol 
• 100-52-7 benzaldehyde 
• 100058-84-2 2-(2'-hydroxy-2'-phenyl)ethyl-1,3-dioxolane 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 4850-49-1 1-phenyl-1,3-propanediol 
• 100-39-0 benzyl bromide 

Downstream Products

• 140854-79-1 (anti)-1-(benzyloxy)-4,4-dimethyl-1-phenyl-5-hexen-3-ol 
• 140854-78-0 (syn)-1-(benzyloxy)-4,4-dimethyl-1-phenyl-5-hexen-3-ol 
• 405114-21-8 2-[2-(benzyloxy)-2-phenylethyl]-1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridine 
• 132816-14-9 1-(benzyloxy)-3-<(3-methyl-2-butenyl)oxy>-1-phenyl-3-(phenylthio)propane 
• 140854-61-1 1-(benzyloxy)-3,3--1-phenylpropane 
• 132816-10-5 C₂₆H₂₈O₂S 
• 132816-10-5 C₂₆H₂₈O₂S 

Relevant academic research and scientific papers

1,3-Asymmetric Induction in Diastereoselective Allylations of Chiral N-Tosyl Imines

Lewis acid mediated allylations of β-alkoxy N-tosyl imines using allyltrimethylsilane lead to 3-alkoxy homoallylic N-tosyl amines with anti-selectivity. Two methods of Cu(OTf)2-mediated allylations are reported herein, demonstrating that diastereoselectiv

Sc(OTf)3-Catalyzed Addition of Bromomagnesium 2-Vinyloxy Ethoxide to Various Aldehydes Leading to Protected Aldol Products

The addition of bromomagnesium 2-vinyloxy ethoxide to various aldehydes in the presence of 10 mol% Sc(OTf)3 provides a broad range of functionalized protected aldol compounds. The enantioselective preparation of these aldols can be achieved via a Swern oxidation-CBS reduction sequence. Use of the dioxolane derived from 2-bromocyclohexanone provides the expected aldol product as the anti diastereoisomer (dr >99:1).

Enantioselective allyltitanations and metathesis reactions. Application to the synthesis of piperidine alkaloids (+)-sedamine and (-)-prosophylline

An enantioselective synthesis of the piperidine alkaloids (+)-sedamine and (-)-prosophylline is reported. The synthesis of (+)-sedamine has been achieved in 12 steps with an overall yield of 20% from benzaldehyde, and (-)-prosophylline was obtained in 15 steps with an overall yield of 9.2%, starting from D-glyceraldehyde acetonide 14. The key steps are enantioselective allyltitanation reactions and ring-closing or cross-metathesis reactions.

Asymmetric Induction in Reductively Initiated -Wittig and Retro -Brook Rearrangements of Secondary Carbanions

The synthesis of O,S-acetals and the lithium naphthalenide initiated rearrangement reactions thereof are described.O,S-Acetal 8a resulted from trapping of the 1,4-dipole 7 with thiophenol.O,S-Acetals 16a and b were obtained from aldehydes 14a/b by a one-p