133867-57-9

Upstream product

• 67-56-1 methanol 
• 157982-25-7 (1R)-tetrahydropyran-(2RS)-2-yl [(1R,3R)-1-(1,3-dithiane-1,3-dioxide-2-yl)-1-phenyl]methyl ether 
• 110-87-2 3,4-dihydro-2H-pyran 
• 21210-43-5 (S)-Methyl mandelate 
• 20698-91-3 (R)-methyl mandelate 
• 611-71-2 (R)-Mandelic Acid 
• 17199-29-0 (S)-Mandelic acid 
• 158060-53-8 (1R,3R)-1,3-dithiane-1,3-dioxide-2-[(1R)-1-phenyl]methanol 
• 100-52-7 benzaldehyde 

Downstream Products

• 105769-50-4 (R)-(+)-2-chloro-2-phenylethyl p-chlorophenyl sulfone 
• 105769-48-0 (R)-(+)-2-chloro-2-phenylethyl p-tolyl sulfone 
• 71899-81-5 (R)-(+)-2-hydroxy-2-phenylethyl p-tolyl sulfone 
• 105769-46-8 (R)-(+)-2-chloro-2-phenylethyl phenyl sulfone 
• 167156-83-4 (R)-2-<(4-methoxyphenyl)sulfanyl>-1-phenylethanol 
• 96938-08-8 (R)-(+)-2-hydroxy-2-phenylethyl p-tolyl sulfide 
• 109183-57-5 (R)-(+)-2-chloro-2-phenylethyl methyl sulfone 
• 5324-56-1 (R)-2-(methylsulfonyl)-1-phenylethanol 
• 121053-49-4 (R)-(+)-1-phenyl-2-(phenylthio)ethan-1-ol 
• 120886-82-0 (R)-1-phenyl-2-(phenylsulfonyl)ethanol 
• 111613-52-6 (R)-2-methylthio-1-phenyl-ethanol 
• 60168-63-0 (R)-(+)-2-phenyl-2-(tetrahydropyranyloxy)ethanol 
• 109183-66-6 (S)-2-phenyl-2-tetrahydropyranyloxy-1-p-toluenesulfonyloxyethane 
• 109183-67-7 2-((S)-1-Phenyl-2-p-tolylsulfanyl-ethoxy)-tetrahydro-pyran 

Relevant academic research and scientific papers

Asymmetric Radical Reaction in the Coordination Sphere. IV. Ruthenium(II)-Catalyzed Asymmetric Addition of Sulfonyl Chloride to 1-Phenylpropene

The asymmetric addition of methane- and p-toluenesulfonyl chloride to 1-phenylpropene catalyzed by Ru2Cl43 affords optically active 1:1 adducts, (+)-(1R,2RS)-1-chloro-2-methylsulfonyl-1-phenylpropane (2) and (+)-(1R,2RS)-1-chloro-1-phenyl-2-tosy

Acetalsulfonate derivative, process for producing the same, and process for producing styrene oxide derivative

There are provided an acetalsulfonate derivative useful as an intermediate for medicines and agricultural chemicals, a process for industrially producing the derivative, and a process for industrially producing a styrene oxide derivative from the acetalsulfonate derivative or from a mandelic acid derivative. A process for producing an acetalsulfonate derivative which comprises a first step of esterifying a mandelic acid derivative to form a mandelic ester derivative, a second step of protecting the mandelic ester derivative by an acetal to form an acetal derivative, a third step of reducing the acetal derivative to form an ethanediol derivative and a fourth step of reacting the ethanediol derivative with a sulfonyl chloride derivative. A process for producing a styrene oxide derivative which comprises a deprotecting step of deacetalizing the acetalsulfonate derivative and a step of epoxidizing the sulfonate derivative obtained in the deprotecting step with the aid of a base catalyst.

Zirconium cation coordination in the borohydride-mediated synthesis of β-hydroxy-N-alkoxylamines

Hydride reductions of oxime ethers to hydroxylamine derivatives are facilitated by the participation of neighboring hydroxyl groups. Precomplexation with zirconium cation in ether-methylene chloride solutions is effective for selective C=N bond reduction. The course for stereochemical control is dictated by Lewis acid coordination complexes of E- and Z-oximino ethers which lead to the preferred diastereofacial delivery of external hydride.

trans-1,3-Dithiane-1,3-Dioxide, a New Chiral Acyl Anion Equivalent for the Preparation of Masked Activated Acids: Application to the Synthesis of α-Hydroxy Acid Derivatives

trans-1,3-Dithiane-1,3-dioxide reacts with high diastereoselectivity with aromatic aldehydes and the 1,3-dithiane-1,3-dioxide moiety can be easily converted to a thiolester without racemisation by carrying out a Pummerer reaction; the thiolester is a group that can be readily transformed into acids, esters, amides, ketones and aldehydes.

Enantioselective Protonation of Samarium Enolates by a C2-Symmetric Chiral Diol

High enantioselectivity (up to 97percentee) have been achieved in the protonation of samarium enolates which were generated by SmI2-mediated cross-coupling reaction between unsymmetrical dialkylketene and allyl iodide, using, using a C2-symmetr

Recognition by New Symmetrically Substituted Chiral Diphenyl- and Di-tert-butylpyridino-18-crown-6 and Asymmetrically Substituted Chiral Dimethylpyridino-18-crown-6 Ligands of the Enantiomers of Various Organic Ammonium Perchlorates

Three new chiral pyridino-18-crown-6 ligands have been prepared.These ligands contain either two phenyl, two tert-butyl, or two methyl substituents on chiral macroring carbon atoms.The chiral di-tert-butyl-substituted diester crown analogue was also prepared.The starting chiral di-tert-butyl-substituted tetraethylene glycol needed to prepare the two di-tert-butyl-substituted crowns was obtained from chiral tert-butyl-1,2-ethanediol, which was resolved from its bis(hydrogen phthalate) brucine salt.A high degree of chiral recognition in CD2Cl2 of the enantiomers of ammonium perchlorate (NapEt) was shown by the diphenyl- and di-tert-butyl-substituted crowns as measured by differences in the free energy of avtivation (ΔGc*) values determined by temperature dependent 1H NMR spectroscopy.The diphenyl- and di-tert-butyl-substituted crowns also exhibited high chiral recognition for the enantiomers of NapEt and other chiral organic ammonium salts in methanol and methanol-chloroform mixtures as shown by a large difference in the log K values determined by a direct 1H NMR technique.

Asymmetric Radical Reaction in the Coordination Sphere. 2. Asymmetric Addition of Alkane- and Arenesulfonyl Chlorides to Olefins Catalyzed by a Ruthenium(II)-Phosphine Complex with Chiral Ligands

The addition of arenesulfonyl chlorides to styrene in the presence of a catalytic amount of a ruthenium(II) complex with chiral phosphine ligands, Ru2Cl43 or Ru2Cl43, proceeds under mild conditions to give optically active 1:1 adducts,