13393-41-4

Basic information

• Product Name: 1H-Pyrazole, 4,5-dihydro-3-(4-methylphenyl)-1,5-diphenyl-
• CAS NO: 13393-41-4
• Molecular Formula: C22H20N2
• Molecular Weight: 312.414
• Mol File: 13393-41-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole, 4,5-dihydro-3-(4-methylphenyl)-1,5-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole, 4,5-dihydro-3-(4-methylphenyl)-1,5-diphenyl-(13393-41-4)
• EPA Substance Registry System: 1H-Pyrazole, 4,5-dihydro-3-(4-methylphenyl)-1,5-diphenyl-(13393-41-4)

Safety Data

• Hazardous Substances Data: 13393-41-4(Hazardous Substances Data)

Usage

Molecular Structure

1H-Pyrazole, 4,5-dihydro-3-(4-methylphenyl)-1,5-diphenylis a chemical compound that consists of a pyrazole ring structure, with a 4,5-dihydro-3-(4-methylphenyl) group and a 1,5-diphenyl group.

Usage

It is commonly used as a building block in organic synthesis and pharmaceutical research.

Potential Applications

1H-Pyrazole, 4,5-dihydro-3-(4-methylphenyl)-1,5-diphenylhas the potential for use in the development of new drugs, due to its diverse biological activities and pharmacological properties.

Medicinal Value

It has been studied for its potential in the treatment of various diseases and conditions, making it a valuable compound in the field of medicinal chemistry.

Upstream product

• 4224-87-7 4-methyl-chalcone 
• 100-63-0 phenylhydrazine 
• 104-87-0 4-methyl-benzaldehyde 
• 98-86-2 acetophenone 
• 59931-62-3 1-(4-methylphenyl)-3-phenylprop-2-yn-1-ol 
• 100-52-7 benzaldehyde 
• 122-00-9 para-methylacetophenone 
• 100-42-5 styrene 
• 20433-11-8 5-(4-methylphenyl)-2-phenyl-2H-tetrazole 
• 14802-30-3 (E)-1-(4-methylphenyl)-3-phenyl-2-propen-1-one 
• 4224-96-8 3-phenyl-1-p-tolylprop-2-en-1-one 

Downstream Products

• 95796-93-3 C₂₃H₂₀ClN₃O₃S 
• 105257-81-6 (4-Nitro-phenyl)-[4-(5-phenyl-3-p-tolyl-4,5-dihydro-pyrazol-1-yl)-phenyl]-diazene 
• 105257-79-2 Phenyl-[4-(5-phenyl-3-p-tolyl-4,5-dihydro-pyrazol-1-yl)-phenyl]-diazene 
• 105257-78-1 [4-(5-Phenyl-3-p-tolyl-4,5-dihydro-pyrazol-1-yl)-phenyl]-p-tolyl-diazene 
• 105257-80-5 (4-Chloro-phenyl)-[4-(5-phenyl-3-p-tolyl-4,5-dihydro-pyrazol-1-yl)-phenyl]-diazene 
• 92708-90-2 1-(4-Acetylphenyl)-3-(4-tolyl)-5-phenyl-2-pyrazoline 
• 63367-45-3 1-(4-Nitrophenyl)-3-(4-tolyl)-5-phenyl-2-pyrazoline 
• 95797-03-8 4-(5-Phenyl-3-p-tolyl-4,5-dihydro-pyrazol-1-yl)-benzamide 
• 1207173-25-8 1-(4'-thiocyanophenyl)-3-(4'-methylphenyl)-5-phenyl-pyrazoline 
• 16112-34-8 (1H)-1,5-diphenyl-3-(p-methylphenyl)pyrazole 

Relevant articles and documents

Regioselective 1,3-dipolar cycloaddition of nitriles with nitrile imines generated from tetrazoles

A synthesis of 3,5-disubstituted-1,2,4-triazoles from nitriles and 5-aryltetrazoles is reported. When 5-aryltetrazoles are triflylated in the presence of nitriles, the resulting 5-aryl-2-triflyltetrazoles thermally generate N-triflyl-nitrile imines through a sequence of ring-chain tautomerization and denitrogenation. The N-triflyl-nitrile imines immediately undergo 1,3-dipolar cycloaddition with nitriles in a regioselective manner, forming the corresponding 1,2,4-triazoles.

Catalytic Synthesis of Chalcones and Pyrazolines Using Nanorod Vanadatesulfuric Acid: An Efficient and Reusable Catalyst

Nanorod vanadatesulfuric acid (VSA NRs), as a recyclable and ecologically benign catalyst, was used for the one-pot synthesis of chalcones and 1,3,5-triaryl-2-pyrazolines (TAPs). Chalcones were prepared via the condensation of substituted acetophenones with aryl-aldehydes under solvent-free conditions. Subsequently, the synthesized chalcones were used for the catalytic synthesis of TAPs via two-component condensation with phenyl hydrazine in refluxing ethanol. VSA is easily prepared by a simple reaction of chlorosulfonic acid and sodium metavanadate of high purity. Compared to conventional procedures, the present protocol offers several advantages such as simplicity of the procedure, appropriate reaction times, high to excellent yields, easily work-up, recoverability, and reusability of the catalyst, and simple purification of the products.

A novel methodology for synthesis of dihydropyrazole derivatives as potential anticancer agents

A novel, simple, and efficient method for the synthesis of 4,5-dihydropyrazole derivatives has been developed. The reaction proceeded through the base-induced isomerization of easily accessible propargyl alcohols followed by cyclization of α,β-unsaturated hydrazones. Furthermore, selected compounds 3ab and 3ac exhibited good activities against Bel-7404 (human hepatoma cancer), HepG2 (human liver cancer), NCI-H460 (human lung cancer) and SKOV3 (human ovarian cancer) cell lines with IC50 in the range of 22-46 μmol L-1.