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6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) is an organic compound with a unique chemical structure that features a central carbonyl group connecting two naphthol-3-sulfonic acid moieties through their 6,6' positions. 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) is known for its pharmacological properties and potential applications in various industries.

134-47-4

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134-47-4 Usage

Uses

Used in Pharmaceutical Industry:
6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) is used as a pharmacologically active compound for its selective nonbisphosphonate inhibition of human geranylgeranyl diphosphate synthase. This inhibition plays a crucial role in the regulation of cellular processes and may have therapeutic implications for various diseases.
Additionally, 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) is used as an inhibitor of shikimate dehydrogenase and shikimate kinase in the shikimate pathway of Helicobacter pylori. This application is significant for the development of novel treatments against bacterial infections, particularly those caused by H. pylori, which is a common cause of gastric ulcers and other gastrointestinal issues.

Check Digit Verification of cas no

The CAS Registry Mumber 134-47-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 4 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 134-47:
(5*1)+(4*3)+(3*4)+(2*4)+(1*7)=44
44 % 10 = 4
So 134-47-4 is a valid CAS Registry Number.

134-47-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 7,7'-(Carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonic acid)

1.2 Other means of identification

Product number -
Other names 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134-47-4 SDS

134-47-4Synthetic route

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

1-hydroxy-6-amino-3-naphthalenesulfonic acid
87-02-5

1-hydroxy-6-amino-3-naphthalenesulfonic acid

AMI-1
134-47-4

AMI-1

Conditions
ConditionsYield
With sodium hydroxide at 60℃; for 6h; pH=7 - 8;90%
phosgene
75-44-5

phosgene

1-hydroxy-6-amino-3-naphthalenesulfonic acid
87-02-5

1-hydroxy-6-amino-3-naphthalenesulfonic acid

AMI-1
134-47-4

AMI-1

Conditions
ConditionsYield
With sodium carbonate
phosgene
75-44-5

phosgene

1-hydroxy-6-amino-3-naphthalenesulfonic acid
87-02-5

1-hydroxy-6-amino-3-naphthalenesulfonic acid

alkali

alkali

AMI-1
134-47-4

AMI-1

AMI-1
134-47-4

AMI-1

N,N-Bis-(3-formamidopropyl)methylamine

N,N-Bis-(3-formamidopropyl)methylamine

4-methoxy-3-nitrobenzyl chloride
6378-19-4

4-methoxy-3-nitrobenzyl chloride

C51H68N12O11S2(2+)*2Cl(1-)

C51H68N12O11S2(2+)*2Cl(1-)

Conditions
ConditionsYield
Multistep reaction;
AMI-1
134-47-4

AMI-1

diazotized 4-nitro-2-amino-phenol

diazotized 4-nitro-2-amino-phenol

4,4'-dihydroxy-3,3'-bis-(2-hydroxy-5-nitro-phenylazo)-7,7'-ureylene-bis-naphthalene-2-sulfonic acid

4,4'-dihydroxy-3,3'-bis-(2-hydroxy-5-nitro-phenylazo)-7,7'-ureylene-bis-naphthalene-2-sulfonic acid

3-aminobenzoic acid ethyl ester
582-33-2

3-aminobenzoic acid ethyl ester

AMI-1
134-47-4

AMI-1

C39H32N6O13S2

C39H32N6O13S2

Conditions
ConditionsYield
Stage #1: 3-aminobenzoic acid ethyl ester With sulfuric acid; sodium nitrite Diazotization;
Stage #2: AMI-1 With sodium carbonate at 20℃; pH=9; azo coupling;
AMI-1
134-47-4

AMI-1

4-amino-2,3,5,6-tetrafluorobenzoic acid
944-43-4

4-amino-2,3,5,6-tetrafluorobenzoic acid

C35H16F8N6O13S2

C35H16F8N6O13S2

Conditions
ConditionsYield
Stage #1: 4-amino-2,3,5,6-tetrafluorobenzoic acid With sulfuric acid; sodium nitrite Diazotization;
Stage #2: AMI-1 With sodium carbonate at 20℃; pH=9; azo coupling;
AMI-1
134-47-4

AMI-1

2,4-dibromo-aniline
615-57-6

2,4-dibromo-aniline

C33H20Br4N6O9S2

C33H20Br4N6O9S2

Conditions
ConditionsYield
Stage #1: 2,4-dibromo-aniline With sulfuric acid; sodium nitrite Diazotization;
Stage #2: AMI-1 With sodium carbonate at 20℃; pH=9; azo coupling;
AMI-1
134-47-4

AMI-1

3-(4-aminophenyl)propionic acid
2393-17-1

3-(4-aminophenyl)propionic acid

3-{4-[6-(3-{6-[4-(2-carboxy-ethyl)-phenylazo]-5-hydroxy-7-sulfo-naphthalen-2-yl}-ureido)-1-hydroxy-3-sulfo-naphthalen-2-ylazo]-phenyl}-propionic acid

3-{4-[6-(3-{6-[4-(2-carboxy-ethyl)-phenylazo]-5-hydroxy-7-sulfo-naphthalen-2-yl}-ureido)-1-hydroxy-3-sulfo-naphthalen-2-ylazo]-phenyl}-propionic acid

Conditions
ConditionsYield
Stage #1: 3-(4-aminophenyl)propionic acid With sulfuric acid; sodium nitrite Diazotization;
Stage #2: AMI-1 With sodium carbonate at 20℃; pH=9; azo coupling;
AMI-1
134-47-4

AMI-1

4-amino 3-methylbenzoic acid
2486-70-6

4-amino 3-methylbenzoic acid

C37H28N6O13S2

C37H28N6O13S2

Conditions
ConditionsYield
Stage #1: 4-amino 3-methylbenzoic acid With sulfuric acid; sodium nitrite Diazotization;
Stage #2: AMI-1 With sodium carbonate at 20℃; pH=9; azo coupling;
AMI-1
134-47-4

AMI-1

trans-p-aminocinnamic acid
17570-30-8

trans-p-aminocinnamic acid

(E)-3-{4-[6-(3-{6-[4-((E)-2-Carboxy-vinyl)-phenylazo]-5-hydroxy-7-sulfo-naphthalen-2-yl}-ureido)-1-hydroxy-3-sulfo-naphthalen-2-ylazo]-phenyl}-acrylic acid

(E)-3-{4-[6-(3-{6-[4-((E)-2-Carboxy-vinyl)-phenylazo]-5-hydroxy-7-sulfo-naphthalen-2-yl}-ureido)-1-hydroxy-3-sulfo-naphthalen-2-ylazo]-phenyl}-acrylic acid

Conditions
ConditionsYield
Stage #1: trans-p-aminocinnamic acid With sulfuric acid; sodium nitrite Diazotization;
Stage #2: AMI-1 With sodium carbonate at 20℃; pH=9; azo coupling;
AMI-1
134-47-4

AMI-1

3-methoxy-4-aminobenzoic acid
2486-69-3

3-methoxy-4-aminobenzoic acid

C37H28N6O15S2

C37H28N6O15S2

Conditions
ConditionsYield
Stage #1: 3-methoxy-4-aminobenzoic acid With sulfuric acid; sodium nitrite Diazotization;
Stage #2: AMI-1 With sodium carbonate at 20℃; pH=9; azo coupling;
AMI-1
134-47-4

AMI-1

2-(4-aminophenyl)-succinic acid
22511-21-3

2-(4-aminophenyl)-succinic acid

2-{4-[6-(3-{6-[4-(1,2-dicarboxy-ethyl)-phenylazo]-5-hydroxy-7-sulfo-naphthalen-2-yl}-ureido)-1-hydroxy-3-sulfo-naphthalen-2-ylazo]-phenyl}-succinic acid

2-{4-[6-(3-{6-[4-(1,2-dicarboxy-ethyl)-phenylazo]-5-hydroxy-7-sulfo-naphthalen-2-yl}-ureido)-1-hydroxy-3-sulfo-naphthalen-2-ylazo]-phenyl}-succinic acid

Conditions
ConditionsYield
Stage #1: 2-(4-aminophenyl)-succinic acid With sulfuric acid; sodium nitrite Diazotization;
Stage #2: AMI-1 With sodium carbonate at 20℃; pH=9; azo coupling;
AMI-1
134-47-4

AMI-1

3-amino-2,5,6-trifluoro benzoic acid
133622-65-8

3-amino-2,5,6-trifluoro benzoic acid

C35H18F6N6O13S2

C35H18F6N6O13S2

Conditions
ConditionsYield
Stage #1: 3-amino-2,5,6-trifluoro benzoic acid With sulfuric acid; sodium nitrite Diazotization;
Stage #2: AMI-1 With sodium carbonate at 20℃; pH=9; azo coupling;
AMI-1
134-47-4

AMI-1

meta-aminobenzoic acid
99-05-8

meta-aminobenzoic acid

C35H24N6O13S2

C35H24N6O13S2

Conditions
ConditionsYield
Stage #1: meta-aminobenzoic acid With sulfuric acid; sodium nitrite Diazotization;
Stage #2: AMI-1 With sodium carbonate at 20℃; pH=9; azo coupling;
AMI-1
134-47-4

AMI-1

4-amino-benzoic acid
150-13-0

4-amino-benzoic acid

calcomine orange

calcomine orange

Conditions
ConditionsYield
Stage #1: 4-amino-benzoic acid With sulfuric acid; sodium nitrite Diazotization;
Stage #2: AMI-1 With sodium carbonate at 20℃; pH=9; azo coupling;
AMI-1
134-47-4

AMI-1

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

C39H32N6O13S2

C39H32N6O13S2

Conditions
ConditionsYield
Stage #1: p-aminoethylbenzoate With sulfuric acid; sodium nitrite Diazotization;
Stage #2: AMI-1 With sodium carbonate at 20℃; pH=9; azo coupling;

134-47-4Downstream Products

134-47-4Relevant academic research and scientific papers

Small molecule inhibitors of histone arginine methyltransferases: Homology modeling, molecular docking, binding mode analysis, and biological evaluations

Ragno, Rino,Simeoni, Silvia,Castellano, Sabrina,Vicidomini, Caterina,Mai, Antonello,Caroli, Antonella,Tramontano, Anna,Bonaccini, Claudia,Trojer, Patrick,Bauer, Ingo,Brosch, Gerald,Sbardella, Gianluca

, p. 1241 - 1253 (2007)

The screening of the inhibition capabilities of dye-like small molecules from a focused library against both human PRMT1 and Aspergillus nidulans RmtA is reported as well as molecular modeling studies (homology modeling, molecular docking, and 3-D QSAR) o

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