1345513-95-2

Basic information

• Product Name: 4-Nitro-2H-pyrazole-3-carboxylic acid Methyl ester
• Synonyms: 4-Nitro-2H-pyrazole-3-carboxylic acid Methyl ester;Methyl 4-nitro-1H-pyrazole-5-carboxylate
• CAS NO: 1345513-95-2
• Molecular Formula: C5H5N3O4
• Molecular Weight: 171.1109
• Mol File: 1345513-95-2.mol
• Article Data: 48

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Nitro-2H-pyrazole-3-carboxylic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitro-2H-pyrazole-3-carboxylic acid Methyl ester(1345513-95-2)
• EPA Substance Registry System: 4-Nitro-2H-pyrazole-3-carboxylic acid Methyl ester(1345513-95-2)

Safety Data

• Hazardous Substances Data: 1345513-95-2(Hazardous Substances Data)

Usage

General Description

4-Nitro-2H-pyrazole-3-carboxylic acid methyl ester is a chemical compound with the molecular formula C6H5N3O4. It is a derivative of pyrazole with a nitro group and a carboxylic acid methyl ester functional group. 4-Nitro-2H-pyrazole-3-carboxylic acid methyl ester is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in research and development as a building block in organic chemistry. Additionally, it has been studied for its potential biological and pharmacological activities. However, it is important to handle this chemical with proper safety precautions due to its potential hazardous properties.

Upstream product

• 75-36-5 acetyl chloride 
• 5334-40-7 4-nitro-1H-pyrazole-3-carboxylic acid 
• 67-56-1 methanol 
• 7719-09-7 thionyl chloride 

Downstream Products

• 65190-36-5 4-nitro-1H-pyrazole-3-carboxamide 
• 400877-57-8 1-methyl-4-nitro-1H-pyrazole-3-carboxylic acid methyl ester 
• 309740-49-6 methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate 
• 637336-53-9 4-amino-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 360056-45-7 methyl 4-amino-1H-pyrazole-3-carboxylate 
• 65190-36-5 4-nitro-1H-pyrazole-5-carboxamide 
• 896467-54-2 4-(2,6-difluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid methyl ester 
• 825619-05-4 methyl 4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxylate 
• 407623-75-0 methyl 1-benzyl-4-nitro-1H-pyrazole-3-carboxylate 
• 923282-48-8 methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate 
• 923283-54-9 methyl 4-amino-1-methyl-1H-pyrazole-5-carboxylate 
• 1021497-94-8 4-[2-(4-bromo-phenylsulfanyl)-2-phenyl-acetylamino]-1-phenethyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 1021497-92-6 4-[3-(4-bromo-phenylsulfanyl)-propionylamino]-1-phenethyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 1021497-78-8 4-[2-(4-nitro-phenylsulfanyl)-acetylamino]-1-phenethyl-1H-pyrazole-3-carboxylic acid methyl ester 

Relevant articles and documents

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The design and synthesis of potent and selective inhibitors of trypanosoma brucei glycogen synthase kinase 3 for the treatment of human African trypanosomiasis

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SUBSTITUTED 2-AZABICYCLO[3.1.1]HEPTANE AND 2-AZABICYCLO[3.2.1]OCTANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

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Design, synthesis and biological evaluation of pyridone–aminal derivatives as MNK1/2 inhibitors

Excessive phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) plays a major role in the dysregulation of mRNA translation and the activation of tumor cell signaling. eIF4E is exclusively phosphorylated by mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1/2) on Ser209. So, MNK1/2 inhibitors could decrease the level of p-eIF4E and regulate tumor-associated signaling pathways. A series of pyridone–aminal derivatives were synthesized and evaluated as MNK1/2 inhibitors. Several compounds exhibited great inhibitory activity against MNK1/2 and selected compounds showed moderate to excellent anti-proliferative potency against hematologic cancer cell lines. In particular, compound 42i (MNK1 IC50 = 7.0 nM; MNK2 IC50 = 6.1 nM) proved to be the most potent compound against TMD-8 cell line with IC50 value of 0.91 μM. Furthermore, 42i could block the phosphorylation level of eIF4E in CT-26 cell line, and 42i inhibited the tumor growth of CT-26 allograft model significantly. These results indicated that compound 42i was a promising MNK1/2 inhibitor for the potent treatment of colon cancer.