134895-40-2

Upstream product

• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 555-21-5 4-Nitrophenylacetonitrile 
• 71189-80-5 2-(4-nitrophenyl)-2-[(trimethylsilyl)oxy]acetonitrile 
• 108-24-7 acetic anhydride 
• 143-33-9 sodium cyanide 
• 555-16-8 4-nitrobenzaldehdye 
• 7677-24-9 trimethylsilyl cyanide 
• 631-57-2 Acetyl cyanide 
• 2929-91-1 4-nitrobenzylidene diacetate 

Relevant academic research and scientific papers

TBD- or PS-TBD-catalyzed one-pot synthesis of cyanohydrin carbonates and cyanohydrin acetates from carbonyl compounds

Cyanation reactions of carbonyl compounds with methyl cyanoformate or acetyl cyanide catalyzed by 5 mol % of 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) were examined. Using methyl cyanoformate, the corresponding cyanohydrin carbonates were readily obtained in high yield for aromatic and aliphatic aldehydes and ketones. Similar results were obtained when acetyl cyanide was used as the cyanide source. The polymer-supported catalyst, PS-TBD, also acted as a good catalyst for this reaction. PS-TBD was easily recovered and reused with minimal activity loss.

One-pot three components synthesis of O-acetylcyanohydrins with TMSCN, acetic anhydride and carbonyl compounds under solvent-free condition

One-pot three components synthesis of O-acetylcyanohydrins has been developed in the presence of B(C6F5)3 as the catalyst. Variety of aldehydes or ketones reacts with TMSCN and acetic anhydride (Ac2O) under the

A one-pot esterification of chiral O-trimethylsilyl-cyanohydrins with retention of stereochemistry

Enantiomerically enriched O-TMS cyanohydrins have been transformed directly into O-acyl-cyanohydrins using various anhydrides or acid chlorides in the presence of catalytic amounts of scandium(III) triflate. The reaction occurs with full retention of ster

The chemistry of acylals. 3. Cyanohydrin esters from acylals with cyanide reagents

(equation presented) When treated with KCN in DMSO at room temperature, acylals from aliphatic aldehydes gave the corresponding cyanohydrin esters in good to excellent yields. Acylals from aromatic aldehydes were less reactive and gave several byproducts in addition to fair yields of cyanohydrin under the same conditions. Trimethylsilyl cyanide mixed with titanium(IV) chloride afforded cyanohydrin esters in good to excellent yields from both aliphatic and aromatic aldehydes.

Acetoxylation of arylacetonitriles using (diacetoxyiodo)benzene

The direct α-acetoxylation of some arylacetonitriles using (diacetoxyiodo)benzene in the presence of dibenzoyl peroxide provides O-acetylated mandelonitriles in good yields.