13544-26-8

Upstream product

• 942-93-8 5-Chloro-1-phenyl-1-pentanone 
• 4509-91-5 5-bromo-1-phenyl-1-pentanone 
• 119645-58-8 Benzoic acid 4,4-dibromo-butyl ester 
• 591-51-5 phenyllithium 
• 124878-43-9 3,4-dihydro-2H-pyran-6-yl trifluoromethanesulfonate 
• 70359-30-7 bromure de benzoyloxy-4 butyltriphenylphosphonium 
• 24595-58-2 5-phenylpent-4-yn-1-ol 
• 591-50-4 iodobenzene 
• 98088-48-3 1-(allyloxy)-1-phenylbut-3-ene 
• 80735-94-0 1-Phenyl-3-buten-1-ol 
• 1575-61-7 5-Chlorovaleroyl chloride 
• 4509-90-4 5-bromovaleroyl chloride 
• 5390-04-5 pent-1-yn-5-ol 
• 1078-58-6 diphenylzinc 

Downstream Products

• 947-17-1 2-ethoxy-2-phenyl-tetrahydro-pyran 
• 1052-07-9 5-[(2,4-Dinitro-phenyl)-hydrazono]-5-phenyl-pentan-1-ol 
• 4509-91-5 5-bromo-1-phenyl-1-pentanone 
• 141957-79-1 phenyl(tetrahydrofuran-2-yl)methanone 
• 16765-45-0 threo-phenyl(tetrahydrofuran-2-yl)methanol 
• 16765-45-0 erythro-phenyl(tetrahydrofuran-2-yl)methanol 
• 870849-11-9 phenyl(tetrahydrofuran-2-yl)methylamine 
• 1025-23-6 5-hydroxy-1,1-diphenylpentene 
• 102374-63-0 N-(2-Chlor-aethoxycarbonyl)-3-methoxy-4-(4-benzoyl-butyloxy)-anilin 
• 15382-91-9 5-<4-Amino-2-methoxy-phenoxy>-1-phenyl-pentanon-(1)-diaethylacetal 
• 15382-89-5 1-Acetoxy-5-<4-amino-2-methoxy-phenoxy>-1-phenyl-pentan 
• 101782-07-4 5-<4-Amino-2-methoxy-phenoxy>-1-phenyl-pentanol-(1) 

Relevant academic research and scientific papers

A NEWS SYNTHESIS OF SPIROACETALS VIA ALKYLIDENATION OF ESTER CARBONYLS WITH METAL CARBANE COMPLEXES

Metal carbene complexes prepared from alkoxy-substitued 1,1-dibromalkanes react with alkoxy-substitued esters to give enol ether intermediates which undergo acid-catalysed methanolysis and cyclisation to spiroacetals in good overall yield.

Regioselectivity Influences in Platinum-Catalyzed Intramolecular Alkyne O-H and N-H Additions

The steric and electronic drivers of regioselectivity in platinum-catalyzed intramolecular hydroalkoxylation are elucidated. A branch point is found that divides the process between 5-exo and 6-endo selective processes, and enol ethers can be accessed in good yields for both oxygen heterocycles. The main influence arises from an electronic effect, where the alkyne substituent induces a polarization of the alkyne that leads to preferential heteroatom attack at the more electron-deficient carbon. The electronic effects are studied in other contexts, including hydroacyloxylation and hydroamination, and similar trends in directionality are predominant although not uniformly observed.

Single-pot access to bisorganoborinates: Applications in zweifel olefination

Zweifel olefination is a catalyst-free reaction that serves alkene functionalization. While most methods employ commercially available boron pinacol esters, we have assembled a sequence in which the two partners of the formal coupling reaction are installed successively, starting from inexpensive boron alkoxides. The in situ formation of bisorganoborinates was accomplished by consecutive reaction of two different organometallic species. This single-pot procedure represents a great advancement in the generation of organoborinates and their involvement in C-C bond formation.

Ruthenium-catalyzed olefin metathesis double-bond isomerization sequence

A novel ruthenium-catalyzed tandem ring-closing metathesis (RCM) double-bond isomerization reaction is described in this paper. The utility of this method for the efficient syntheses of five-, six-, and seven-membered cyclic enol ethers is demonstrated. It relies on the conversion of a metathesis-active ruthenium carbene species to an isomerization-active ruthenium-hydride species in situ. This conversion is achieved by using various additives. Scope and limitations of the different protocols are discussed, and some mechanistic considerations based on 31P and 1H NMR spectroscopic studies are presented.

Palladium-catalyzed cross-coupling reactions between dihydropyranylindium reagents and aryl halides. Synthesis of C-aryl glycals

(Matrix presented) Palladium(0)-catalyzed cross-coupling reactions between tris(dihydropyranyl)indium 1 and aryl halides 2 have been investigated. Aryl iodides and electron-deficient aryl bromides couple efficiently with the in situ-generated indium reage

An olefin metathesis/double bond isomerization sequence catalyzed by an in situ generated ruthenium hydride species

The direct conversion of allyl ethers to cyclic enol ethers using an olefin metathesis/double bond migration sequence is described. Ruthenium carbene complexes were activated to catalyze the double bond migration step by addition of hydride sources, such

Conversion of Lactones into Substituted Cyclic Ethers

Lactone enolates were treated with N-phenyl triflimide in the presence of hexamethylphosphoric triamide to afford smoothly the corresponding enol triflates, which, on reaction with lithium dialkylcuprates, gave rise to alkylated cyclic ethers in good yields.

ACYLOXYALKYLIDENEPHOSPHORANES-II; ETUDE DES Ω-ACYLOXY N-BUTYLIDENETRIPHENYLPHOSPHORANES. NOUVELLE VOIE D'ACCES AUX DIHYDRO-3,4 2H-PYRANNES

ω-Acyloxy n-butylidenetriphenylphosphoranes give α-acyl n-butylidenetriphenylphosphoranes by intermolecular condensation in t-BuOH, and 3,4-dihydro-(2H)-pyrans by intramolecular condensation in toluene.The α-acyl n-butylidene phosphoranes, which are the t