13558-77-5

Basic information

• Product Name: 1-(2-chloroacetyl)-3-p-tolylurea
• Synonyms: 1-(2-chloroacetyl)-3-p-tolylurea
• CAS NO: 13558-77-5
• Molecular Formula: C₁₀H₁₁ClN₂O₂
• Molecular Weight: 226.65954
• Mol File: 13558-77-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.313g/cm³
• Refractive Index: 1.592
• CAS DataBase Reference: 1-(2-chloroacetyl)-3-p-tolylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroacetyl)-3-p-tolylurea(13558-77-5)
• EPA Substance Registry System: 1-(2-chloroacetyl)-3-p-tolylurea(13558-77-5)

Safety Data

• Hazardous Substances Data: 13558-77-5(Hazardous Substances Data)

Usage

General Description

1-(2-chloroacetyl)-3-p-tolylurea, also known as chlorpropham, is a chemical compound commonly used as a herbicide and plant growth regulator. It inhibits sprouting of potatoes and other crops by interfering with cell division and growth processes. It is a white crystalline solid with a faint odor, and it is slightly soluble in water and more soluble in organic solvents. Chlorpropham is considered to have low acute toxicity to mammals, but chronic exposure may have negative effects on human health. It is classified as a possible human carcinogen by the International Agency for Research on Cancer. Due to its potential health and environmental impacts, the use and regulation of chlorpropham in agriculture is subject to scrutiny and control in many countries.

InChI:InChI=1/C10H11ClN2O2/c1-7-2-4-8(5-3-7)12-10(15)13-9(14)6-11/h2-5H,6H2,1H3,(H2,12,13,14,15)

Upstream product

• 79-37-8 oxalyl dichloride 
• 106-49-0 p-toluidine 
• 79-07-2 Chloroacetamide 
• 471-46-5 Oxalamide 
• 622-51-5 p-tolylurea 
• 79-04-9 chloroacetyl chloride 
• 4461-30-7 2-chloroacetylisocyanate 

Downstream Products

• 38523-89-6 2-morpholin-4-yl-N-p-tolylcarbamoyl-acetamide 
• 13558-98-0 Dithiophosphorsaeure- 
• 13561-95-0 Dithiophosphorsaeure- 
• 5711-50-2 N--N'-p-tolyl-harnstoff 
• 76979-62-9 1-{2-[(4-Oxo-4H-quinazolin-3-ylmethyl)-amino]-acetyl}-3-p-tolyl-urea 
• 100805-85-4 1-[2-(1-Phenyl-1H-tetrazol-5-ylsulfanyl)-acetyl]-3-p-tolyl-urea 
• 76979-63-0 1-{2-[(6-Bromo-4-oxo-4H-quinazolin-3-ylmethyl)-amino]-acetyl}-3-p-tolyl-urea 
• 76427-16-2 1-(2-{N'-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazino}-acetyl)-3-p-tolyl-urea 
• 76427-15-1 1-(2-{N'-[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-hydrazino}-acetyl)-3-p-tolyl-urea 
• 76427-14-0 1-(2-{N'-[1-(2-Hydroxy-phenyl)-meth-(E)-ylidene]-hydrazino}-acetyl)-3-p-tolyl-urea 

Relevant articles and documents

A concise approach to n-substituted rhodanines through a base-assisted one-pot coupling and cyclization process

An efficient approach to obtain functionalized rhodanines was developed through a base-assisted one-pot coupling and continuous cyclization of a primary amine, carbon disulfide, and methyl (2-chloroacetyl)carbamate. This conversion tolerates a broad range of functional groups and can be used to scale the preparation of N-substituted rhodanines in excellent yields.

Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress

We prepared a series of quinoxalin-2-mercapto-acetyl-urea analogs and evaluated them for their ability to inhibit viral egress in our Marburg and Ebola VP40 VLP budding assays in HEK293T cells. We also evaluated selected compounds in our bimolecular complementation assay (BiMC) to detect and visualize a Marburg mVP40–Nedd4 interaction in live mammalian cells. Antiviral activity was assessed for selected compounds using a live recombinant vesicular stomatitis virus (VSV) (M40 virus) that expresses the EBOV VP40 PPxY L-domain. Finally selected compounds were evaluated in several ADME assays to have an early assessment of their drug properties. Our compounds had low nM potency in these assays (e.g., compounds 21, 24, 26, 39), and had good human liver microsome stability, as well as little or no inhibition of P450 3A4.

Synthesis and evaluation of substituted 4(3H)-quinazolone derivatives for antimicrobial and antiacetylcholinesterase activities. Part 3

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