13608-28-1

Basic information

• Product Name: 4,4-dimethyl-2-(2-phenylethyl)-4,5-dihydro-1,3-oxazole
• CAS NO: 13608-28-1
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.2802
• Mol File: 13608-28-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 290.8°C at 760 mmHg
• Flash Point: 98°C
• Density: 1.01g/cm³
• Vapor Pressure: 0.00352mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: 4,4-dimethyl-2-(2-phenylethyl)-4,5-dihydro-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-dimethyl-2-(2-phenylethyl)-4,5-dihydro-1,3-oxazole(13608-28-1)
• EPA Substance Registry System: 4,4-dimethyl-2-(2-phenylethyl)-4,5-dihydro-1,3-oxazole(13608-28-1)

Safety Data

• Hazardous Substances Data: 13608-28-1(Hazardous Substances Data)

Upstream product

• 103-25-3 3-phenylpropanoic acid methyl ester 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 61025-23-8 (E)-4,4-dimethyl-2-(2-phenylethenyl)-4,5-dihydro-1,3-oxazole 
• 100-42-5 styrene 
• 30093-99-3 4,4-dimethyl-2-oxazoline 
• 501-52-0 3-Phenylpropionic acid 
• 1772-43-6 2,4,4-trimethyl oxazoline 
• 100-44-7 benzyl chloride 

Downstream Products

• 29805-48-9 2-benzyl-pent-4-enoic acid ethyl ester 
• 6540-96-1 2-benzyl-4-pentenoic acid 
• 5669-19-2 2-Benzyl-2-propenoic acid 
• 78763-98-1 2-(1-Benzyl-vinyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 1009-67-2 2-methyl-3-phenylpropanoic acid 
• 34666-01-8 ethyl 2-methyl-3-phenylpropionate 
• 51869-23-9 sec-butyl-3-phenylpropionate 
• 22767-95-9 1-methylethyl 3-phenylpropionoate 
• 5668-19-9 acide 2-benzyl-hexanoique 
• 57772-77-7 ethyl 2-butyl-3-phenylpropanoate 

Relevant articles and documents

CONDENSATION REACTION BY METAL CATALYST

The invention relates to a method for producing an azoline compound represented by the general formula (3): wherein R1 represents an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; R3, R4, R5 and R6 may be the same or different and each represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; two arbitrary groups selected from R3, R4, R5 and R6 may bond to each other to form a ring; and Z1 represents an oxygen atom, a sulfur atom or a selenium atom; comprising reacting a carboxylic acid or a carboxylic acid derivative represented by the general formula (1): ????????R1CO2R2?????(1) wherein R1 is as defined above; R2 represents a hydrogen atom, an optionally substituted alkyl group or an optionally substituted aryl group; and R1 and R2 may bond to each other to form a ring; with an aminochalcogenide represented by the general formula (2): wherein R3, R4, R5, R6 and Z1 are as defined above; in the presence of a compound containing a group 12 metal element in the periodic table.

Stereoselective Construction of Acyclic Carbon Chains by a One-Pot Coupling Process Based on Alkenyloxazoline-Titanium Complexes

A versatile organometallic intermediate, an alkenyloxazoline-titanium complex, has been developed that enables one-pot multicomponent diastereoselective and asymmetric coupling processes to be achieved in a remarkably efficient manner (see scheme).

Novel Synthesis of α-Substituted Acrylic Acids

A facile three-step procedure has been developed for the synthesis of α-substituted acrylic acids.In the first step, a carboxylic acid having no α-substituents is condensed with 2-amino-2-methylpropanol (AMP) to form the corresponding oxazoline.The oxazoline reacts readily with paraformaldehyde to give an intermediate mixture of mono- and dimethylol derivatives which upon heating forms the α-methylene derivatives of the oxazoline.The latter, upon acid hydrolysis, yields the α-substituted acrylic acid generally in an overall yield of above 70percent and the acids are usually at least 95percent pure.