136401-24-6

Basic information

• Product Name: benzyl N-(1-methoxy-1-phenylmethyl)carbamate
• Synonyms: benzyl N-(1-methoxy-1-phenylmethyl)carbamate
• CAS NO: 136401-24-6
• Molecular Weight: 271.316
• Mol File: 136401-24-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: benzyl N-(1-methoxy-1-phenylmethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl N-(1-methoxy-1-phenylmethyl)carbamate(136401-24-6)
• EPA Substance Registry System: benzyl N-(1-methoxy-1-phenylmethyl)carbamate(136401-24-6)

Safety Data

• Hazardous Substances Data: 136401-24-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 38091-74-6 N-(benzyloxycarbonyl)benzamide 
• 5491-18-9 2-(benzyloxycarbonylamino)-2-phenylacetic acid 
• 100-52-7 benzaldehyde 
• 124-41-4 sodium methylate 
• 383366-27-6 benzyl phenyl(phenylsulfonyl)methylcarbamate 
• 621-84-1 O-benzyl carbamate 
• 5491-18-9 (S)-N-(benzyloxycarbonyl)phenylglycine 

Downstream Products

• 1312310-27-2 ethyl 4-([(benzyloxy)carbonyl]amino)-2-oxo-4-phenylbutanoate 
• 372199-85-4 [phenyl-(toluene-4-sulfonyl)-methyl]-carbamic acid benzyl ester 
• 125453-15-8 benzyl carbamate 
• 136401-37-1 [(S)-((S)-5-Oxo-2,5-dihydro-furan-2-yl)-phenyl-methyl]-carbamic acid benzyl ester 
• 919770-43-7 (+)-[(5-oxo-2,5-dihydrofuran-2-yl)(phenyl)methyl]carbamic acid benzyl ester 
• 1353682-15-1 benzyl (R)-(1-phenylbuta-2,3-dien-1-yl)carbamate 

Relevant articles and documents

Non-Kolbe electrolysis of

Here, we report a standardized method for the synthesis of N-protected (1-methoxyalkyl)amines by the electrochemical decarboxylative α-methoxylation of α-amino acid derivatives using the commercially available, easy-to-use, compact ElectraSyn 2.0 setup. T

Catalyst-free Friedel-Crafts reaction of 1-(N-acylamino)alkyltriarylphosphonium salts with electron-rich arenes

Friedel-Crafts reaction of 1-(N-acylamino)alkyltriarylphosphonium salts with arenes or heteroarenes without the need for any catalyst provided access to a wide range of biologically interesting N-(1-arylalkyl)amides or 1-arylalkylphosphonium salts which c

α-amidoalkylating agents from N-acyl-α-amino acids: 1-(N-acylamino)alkyltriphenylphosphonium salts

N-Acyl-α-amino acids were efficiently transformed in a two-step procedure into 1-N-(acylamino)alkyltriphenylphosphonium salts, new powerful α-amidoalkylating agents. The effect of the α-amino acid structure, the base used [MeONa or a silica gel-supported piperidine (SiO 2-Pip)], and the main electrolysis parameters (current density, charge consumption) on the yield and selectivity of the electrochemical decarboxylative α-methoxylation of N-acyl-α-amino acids (Hofer-Moest reaction) was investigated. For most proteinogenic and all studied unproteinogenic α-amino acids, very good results were obtained using a substoichiometric amount of SiO2-Pip as the base. Only in the cases of N-acylated cysteine, methionine, and tryptophan, attempts to carry out the Hofer-Moest reaction in the applied conditions failed, probably because of the susceptibility of these α-amino acids to an electrochemical oxidation on the side chain. The methoxy group of N-(1-methoxyalkyl)amides was effectively displaced with the triphenylphosphonium group by dissolving an equimolar amount of N-(1-methoxyalkyl)amide and triphenylphosphonium tetrafluoroborate in CH 2Cl2 at room temperature for 30 min, followed by the precipitation of 1-N-(acylamino)alkyltriphenylphosphonium salt with Et 2O.